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Gene: MXRA5 |
Gene summary for MXRA5 |
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Gene information | Species | Human | Gene symbol | MXRA5 | Gene ID | 25878 |
Gene name | matrix remodeling associated 5 | |
Gene Alias | MXRA5 | |
Cytomap | Xp22.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9NR99 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25878 | MXRA5 | LZE8T | Human | Esophagus | ESCC | 8.06e-04 | 1.35e-01 | 0.067 |
25878 | MXRA5 | LZE20T | Human | Esophagus | ESCC | 2.73e-03 | 2.06e-01 | 0.0662 |
25878 | MXRA5 | P5T-E | Human | Esophagus | ESCC | 5.64e-05 | 3.91e-01 | 0.1327 |
25878 | MXRA5 | P8T-E | Human | Esophagus | ESCC | 5.17e-13 | 5.56e-01 | 0.0889 |
25878 | MXRA5 | P9T-E | Human | Esophagus | ESCC | 7.09e-07 | 5.17e-01 | 0.1131 |
25878 | MXRA5 | P10T-E | Human | Esophagus | ESCC | 1.10e-18 | 5.46e-01 | 0.116 |
25878 | MXRA5 | P11T-E | Human | Esophagus | ESCC | 3.35e-21 | 1.14e+00 | 0.1426 |
25878 | MXRA5 | P12T-E | Human | Esophagus | ESCC | 1.12e-11 | 3.75e-01 | 0.1122 |
25878 | MXRA5 | P15T-E | Human | Esophagus | ESCC | 2.50e-06 | 4.52e-01 | 0.1149 |
25878 | MXRA5 | P21T-E | Human | Esophagus | ESCC | 3.89e-07 | 2.54e-01 | 0.1617 |
25878 | MXRA5 | P32T-E | Human | Esophagus | ESCC | 2.29e-02 | 3.35e-01 | 0.1666 |
25878 | MXRA5 | P36T-E | Human | Esophagus | ESCC | 2.00e-05 | 5.52e-01 | 0.1187 |
25878 | MXRA5 | P42T-E | Human | Esophagus | ESCC | 3.30e-03 | 4.91e-01 | 0.1175 |
25878 | MXRA5 | P44T-E | Human | Esophagus | ESCC | 1.02e-11 | 9.87e-01 | 0.1096 |
25878 | MXRA5 | P47T-E | Human | Esophagus | ESCC | 3.74e-10 | 6.79e-01 | 0.1067 |
25878 | MXRA5 | P54T-E | Human | Esophagus | ESCC | 4.50e-05 | 1.45e-01 | 0.0975 |
25878 | MXRA5 | P61T-E | Human | Esophagus | ESCC | 4.08e-33 | 1.59e+00 | 0.099 |
25878 | MXRA5 | P62T-E | Human | Esophagus | ESCC | 1.48e-05 | 1.68e-01 | 0.1302 |
25878 | MXRA5 | P65T-E | Human | Esophagus | ESCC | 1.49e-04 | 2.78e-01 | 0.0978 |
25878 | MXRA5 | P79T-E | Human | Esophagus | ESCC | 6.28e-13 | 4.43e-01 | 0.1154 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:00715598 | Oral cavity | OSCC | response to transforming growth factor beta | 140/7305 | 256/18723 | 2.34e-07 | 3.70e-06 | 140 |
GO:00715597 | Prostate | BPH | response to transforming growth factor beta | 76/3107 | 256/18723 | 1.14e-07 | 2.73e-06 | 76 |
GO:007155915 | Prostate | Tumor | response to transforming growth factor beta | 76/3246 | 256/18723 | 6.86e-07 | 1.40e-05 | 76 |
GO:007155917 | Skin | cSCC | response to transforming growth factor beta | 95/4864 | 256/18723 | 5.21e-05 | 5.31e-04 | 95 |
GO:007155919 | Thyroid | PTC | response to transforming growth factor beta | 131/5968 | 256/18723 | 9.20e-11 | 3.17e-09 | 131 |
GO:007155925 | Thyroid | ATC | response to transforming growth factor beta | 142/6293 | 256/18723 | 4.30e-13 | 1.94e-11 | 142 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MXRA5 | SNV | Missense_Mutation | rs193920874 | c.5788G>A | p.Ala1930Thr | p.A1930T | Q9NR99 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MXRA5 | SNV | Missense_Mutation | c.3211N>C | p.Asn1071His | p.N1071H | Q9NR99 | protein_coding | tolerated(0.06) | benign(0.094) | TCGA-D7-A4Z0-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracilum | SD | |
MXRA5 | SNV | Missense_Mutation | novel | c.6446C>T | p.Thr2149Met | p.T2149M | Q9NR99 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-D7-A6F2-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MXRA5 | SNV | Missense_Mutation | c.7222G>T | p.Ala2408Ser | p.A2408S | Q9NR99 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-FP-7829-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
MXRA5 | SNV | Missense_Mutation | rs201160511 | c.6256N>A | p.Gly2086Ser | p.G2086S | Q9NR99 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
MXRA5 | SNV | Missense_Mutation | c.62C>T | p.Pro21Leu | p.P21L | Q9NR99 | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
MXRA5 | SNV | Missense_Mutation | c.4543A>T | p.Ser1515Cys | p.S1515C | Q9NR99 | protein_coding | deleterious(0) | benign(0.334) | TCGA-HU-A4GF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MXRA5 | SNV | Missense_Mutation | rs745871213 | c.2045N>A | p.Arg682His | p.R682H | Q9NR99 | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MXRA5 | SNV | Missense_Mutation | novel | c.8336N>A | p.Val2779Asp | p.V2779D | Q9NR99 | protein_coding | deleterious(0) | benign(0.288) | TCGA-RD-A7BT-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MXRA5 | SNV | Missense_Mutation | rs777665295 | c.5599G>A | p.Ala1867Thr | p.A1867T | Q9NR99 | protein_coding | deleterious(0.04) | benign(0.413) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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