Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004225510 | Cervix | CC | ribosome assembly | 25/2311 | 61/18723 | 1.70e-08 | 1.27e-06 | 25 |
GO:004227310 | Cervix | CC | ribosomal large subunit biogenesis | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:002261810 | Cervix | CC | ribonucleoprotein complex assembly | 49/2311 | 220/18723 | 2.52e-05 | 4.29e-04 | 49 |
GO:000002710 | Cervix | CC | ribosomal large subunit assembly | 12/2311 | 27/18723 | 3.52e-05 | 5.65e-04 | 12 |
GO:007182610 | Cervix | CC | ribonucleoprotein complex subunit organization | 49/2311 | 227/18723 | 5.91e-05 | 8.54e-04 | 49 |
GO:00160727 | Cervix | CC | rRNA metabolic process | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
GO:007182616 | Endometrium | AEH | ribonucleoprotein complex subunit organization | 65/2100 | 227/18723 | 4.47e-13 | 1.07e-10 | 65 |
GO:002261816 | Endometrium | AEH | ribonucleoprotein complex assembly | 63/2100 | 220/18723 | 1.02e-12 | 2.24e-10 | 63 |
GO:004227316 | Endometrium | AEH | ribosomal large subunit biogenesis | 30/2100 | 72/18723 | 3.69e-11 | 5.03e-09 | 30 |
GO:004225516 | Endometrium | AEH | ribosome assembly | 26/2100 | 61/18723 | 4.06e-10 | 4.20e-08 | 26 |
GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
GO:000002716 | Endometrium | AEH | ribosomal large subunit assembly | 12/2100 | 27/18723 | 1.32e-05 | 2.84e-04 | 12 |
GO:00063648 | Endometrium | AEH | rRNA processing | 47/2100 | 225/18723 | 1.78e-05 | 3.65e-04 | 47 |
GO:00160728 | Endometrium | AEH | rRNA metabolic process | 48/2100 | 236/18723 | 3.01e-05 | 5.54e-04 | 48 |
GO:00344707 | Endometrium | AEH | ncRNA processing | 62/2100 | 395/18723 | 3.93e-03 | 2.65e-02 | 62 |
GO:002261317 | Endometrium | EEC | ribonucleoprotein complex biogenesis | 108/2168 | 463/18723 | 4.60e-13 | 9.86e-11 | 108 |
GO:007182617 | Endometrium | EEC | ribonucleoprotein complex subunit organization | 65/2168 | 227/18723 | 1.91e-12 | 3.58e-10 | 65 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MDN1 | SNV | Missense_Mutation | | c.6083N>T | p.Gly2028Val | p.G2028V | Q9NU22 | protein_coding | deleterious(0.01) | benign(0.048) | TCGA-46-3765-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MDN1 | SNV | Missense_Mutation | | c.6802N>T | p.Ser2268Cys | p.S2268C | Q9NU22 | protein_coding | deleterious(0.01) | probably_damaging(0.926) | TCGA-51-4079-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MDN1 | SNV | Missense_Mutation | novel | c.8710G>C | p.Glu2904Gln | p.E2904Q | Q9NU22 | protein_coding | tolerated(0.07) | benign(0.328) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MDN1 | SNV | Missense_Mutation | novel | c.13736N>T | p.Ser4579Phe | p.S4579F | Q9NU22 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
MDN1 | SNV | Missense_Mutation | rs149622123 | c.7793N>A | p.Arg2598Gln | p.R2598Q | Q9NU22 | protein_coding | tolerated(0.05) | benign(0.213) | TCGA-56-8082-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MDN1 | SNV | Missense_Mutation | rs763315551 | c.8347N>C | p.Asn2783His | p.N2783H | Q9NU22 | protein_coding | deleterious(0.03) | possibly_damaging(0.687) | TCGA-56-A4ZJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MDN1 | SNV | Missense_Mutation | | c.8292N>A | p.Met2764Ile | p.M2764I | Q9NU22 | protein_coding | tolerated(0.66) | benign(0) | TCGA-63-5128-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | PD |
MDN1 | SNV | Missense_Mutation | novel | c.8394G>T | p.Leu2798Phe | p.L2798F | Q9NU22 | protein_coding | deleterious(0) | possibly_damaging(0.601) | TCGA-63-A5MP-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
MDN1 | SNV | Missense_Mutation | rs373924943 | c.14314N>A | p.Asp4772Asn | p.D4772N | Q9NU22 | protein_coding | deleterious(0) | benign(0.07) | TCGA-63-A5MT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
MDN1 | SNV | Missense_Mutation | | c.4791G>C | p.Lys1597Asn | p.K1597N | Q9NU22 | protein_coding | deleterious(0.05) | benign(0.011) | TCGA-66-2744-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |