GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:20012349 | Breast | Precancer | negative regulation of apoptotic signaling pathway | 39/1080 | 224/18723 | 5.35e-10 | 4.77e-08 | 39 |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00313349 | Breast | Precancer | positive regulation of protein-containing complex assembly | 33/1080 | 237/18723 | 2.39e-06 | 8.21e-05 | 33 |
GO:20012369 | Breast | Precancer | regulation of extrinsic apoptotic signaling pathway | 24/1080 | 151/18723 | 5.78e-06 | 1.70e-04 | 24 |
GO:00971919 | Breast | Precancer | extrinsic apoptotic signaling pathway | 30/1080 | 219/18723 | 9.42e-06 | 2.50e-04 | 30 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:20012379 | Breast | Precancer | negative regulation of extrinsic apoptotic signaling pathway | 16/1080 | 97/18723 | 1.29e-04 | 2.24e-03 | 16 |
GO:00004226 | Breast | Precancer | autophagy of mitochondrion | 14/1080 | 81/18723 | 2.01e-04 | 3.16e-03 | 14 |
GO:00617266 | Breast | Precancer | mitochondrion disassembly | 14/1080 | 81/18723 | 2.01e-04 | 3.16e-03 | 14 |
GO:00070159 | Breast | Precancer | actin filament organization | 44/1080 | 442/18723 | 3.02e-04 | 4.35e-03 | 44 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00160497 | Breast | Precancer | cell growth | 46/1080 | 482/18723 | 5.63e-04 | 7.16e-03 | 46 |
GO:00108217 | Breast | Precancer | regulation of mitochondrion organization | 19/1080 | 144/18723 | 6.26e-04 | 7.78e-03 | 19 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:00068986 | Breast | Precancer | receptor-mediated endocytosis | 27/1080 | 244/18723 | 9.01e-04 | 1.03e-02 | 27 |
GO:00322739 | Breast | Precancer | positive regulation of protein polymerization | 18/1080 | 138/18723 | 9.85e-04 | 1.11e-02 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTN | insertion | Nonsense_Mutation | novel | c.63476_63477insTGTTCTTACATTTCTTTCCTCTTGGTTCATGTAGA | p.Lys21160ValfsTer11 | p.K21160Vfs*11 | | protein_coding | | | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
TTN | insertion | In_Frame_Ins | novel | c.28257_28258insCTGCAAACAAATATTAATCCCAGACAAAAG | p.His9419_Val9420insLeuGlnThrAsnIleAsnProArgGlnLys | p.H9419_V9420insLQTNINPRQK | | protein_coding | | | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
TTN | insertion | Frame_Shift_Ins | novel | c.76473_76474insTATCTTTTTAGAGTTGTTGCTGTAAATG | p.His25492TyrfsTer12 | p.H25492Yfs*12 | | protein_coding | | | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
TTN | insertion | Frame_Shift_Ins | novel | c.9743_9744insATTTTTAAATG | p.Thr3249PhefsTer17 | p.T3249Ffs*17 | | protein_coding | | | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
TTN | insertion | Frame_Shift_Ins | novel | c.102427_102428insGTTTTGAGTCAGCAGCCTTTCACACTGGACCATGC | p.Met34143SerfsTer38 | p.M34143Sfs*38 | | protein_coding | | | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TTN | insertion | Frame_Shift_Ins | novel | c.12850_12851insCCCAGGGAAAGATTATAAGATCTGTTTTGAAG | p.Gln4284ProfsTer13 | p.Q4284Pfs*13 | | protein_coding | | | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TTN | insertion | Nonsense_Mutation | novel | c.43102_43103insCTTGAACCCAGGAGGCGGAGGTTGTAGCGAGCCAAGATCGCG | p.Ile14367_Glu14368insAlaTerThrGlnGluAlaGluValValAlaSerGlnAspArg | p.I14367_E14368insA*TQEAEVVASQDR | | protein_coding | | | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTN | insertion | Frame_Shift_Ins | novel | c.49253_49254insGGAATAC | p.Asn16418LysfsTer4 | p.N16418Kfs*4 | | protein_coding | | | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD |
TTN | insertion | Frame_Shift_Ins | novel | c.94204_94205insGCACAGAGAGATGGATGAAGGTTGTCACC | p.Ala31402GlyfsTer65 | p.A31402Gfs*65 | | protein_coding | | | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
TTN | insertion | Nonsense_Mutation | novel | c.94312_94313insACTAAAGAAAAGTCCCTAAGAATGGGTACTTTAAGTAATGAGCTTAGC | p.Ser31438delinsAsnTerArgLysValProLysAsnGlyTyrPheLysTerTerAlaTerArg | p.S31438delinsN*RKVPKNGYFK**A*R | | protein_coding | | | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |