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Gene: KIAA1109 |
Gene summary for KIAA1109 |
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Gene information | Species | Human | Gene symbol | KIAA1109 | Gene ID | 84162 |
Gene name | KIAA1109 | |
Gene Alias | ALKKUCS | |
Cytomap | 4q27 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q2LD37 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84162 | KIAA1109 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.92e-30 | -8.52e-01 | 0.0155 |
84162 | KIAA1109 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.08e-12 | -6.74e-01 | -0.1808 |
84162 | KIAA1109 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.37e-03 | -6.56e-01 | 0.0216 |
84162 | KIAA1109 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.33e-16 | -8.12e-01 | -0.1207 |
84162 | KIAA1109 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.59e-25 | -6.26e-01 | -0.1464 |
84162 | KIAA1109 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.79e-10 | -4.84e-01 | -0.1001 |
84162 | KIAA1109 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.06e-10 | -6.02e-01 | -0.059 |
84162 | KIAA1109 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.39e-02 | -6.57e-01 | -0.1706 |
84162 | KIAA1109 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.64e-02 | -6.25e-01 | -0.2061 |
84162 | KIAA1109 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.35e-06 | -6.28e-01 | -0.0842 |
84162 | KIAA1109 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.59e-03 | -9.05e-01 | -0.00410000000000005 |
84162 | KIAA1109 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.12e-03 | -5.94e-01 | -0.0179 |
84162 | KIAA1109 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.56e-27 | -8.28e-01 | 0.096 |
84162 | KIAA1109 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.17e-03 | -6.81e-01 | 0.0446 |
84162 | KIAA1109 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.49e-05 | -9.99e-01 | 0.0451 |
84162 | KIAA1109 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.40e-07 | -8.75e-01 | 0.0528 |
84162 | KIAA1109 | HTA11_10623_2000001011 | Human | Colorectum | AD | 5.21e-06 | -6.20e-01 | -0.0177 |
84162 | KIAA1109 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.47e-03 | -6.52e-01 | 0.0171 |
84162 | KIAA1109 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.08e-15 | -7.67e-01 | 0.0338 |
84162 | KIAA1109 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.87e-29 | -7.35e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0032456 | Colorectum | AD | endocytic recycling | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
GO:00988761 | Colorectum | SER | vesicle-mediated transport to the plasma membrane | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00015581 | Colorectum | SER | regulation of cell growth | 90/2897 | 414/18723 | 4.00e-04 | 6.02e-03 | 90 |
GO:00160491 | Colorectum | SER | cell growth | 100/2897 | 482/18723 | 1.07e-03 | 1.24e-02 | 100 |
GO:00988762 | Colorectum | MSS | vesicle-mediated transport to the plasma membrane | 54/3467 | 136/18723 | 6.20e-09 | 3.95e-07 | 54 |
GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
GO:00160492 | Colorectum | MSS | cell growth | 123/3467 | 482/18723 | 7.15e-05 | 1.21e-03 | 123 |
GO:00015582 | Colorectum | MSS | regulation of cell growth | 105/3467 | 414/18723 | 2.97e-04 | 3.90e-03 | 105 |
GO:00324561 | Colorectum | MSS | endocytic recycling | 26/3467 | 73/18723 | 4.05e-04 | 4.99e-03 | 26 |
GO:00990031 | Colorectum | MSS | vesicle-mediated transport in synapse | 54/3467 | 200/18723 | 1.94e-03 | 1.67e-02 | 54 |
GO:0099504 | Colorectum | MSS | synaptic vesicle cycle | 48/3467 | 181/18723 | 4.85e-03 | 3.39e-02 | 48 |
GO:0048488 | Colorectum | MSS | synaptic vesicle endocytosis | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
GO:0140238 | Colorectum | MSS | presynaptic endocytosis | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
GO:0036465 | Colorectum | MSS | synaptic vesicle recycling | 23/3467 | 75/18723 | 7.49e-03 | 4.72e-02 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1109 | SNV | Missense_Mutation | novel | c.14542N>C | p.Glu4848Gln | p.E4848Q | Q2LD37 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA1109 | SNV | Missense_Mutation | novel | c.11519A>T | p.Lys3840Met | p.K3840M | Q2LD37 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KIAA1109 | SNV | Missense_Mutation | novel | c.6113N>T | p.Gly2038Val | p.G2038V | Q2LD37 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA1109 | SNV | Missense_Mutation | rs772064200 | c.3321N>C | p.Lys1107Asn | p.K1107N | Q2LD37 | protein_coding | deleterious(0) | benign(0.351) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIAA1109 | SNV | Missense_Mutation | c.4289G>T | p.Arg1430Met | p.R1430M | Q2LD37 | protein_coding | deleterious_low_confidence(0) | benign(0.003) | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA1109 | SNV | Missense_Mutation | c.5900G>A | p.Gly1967Glu | p.G1967E | Q2LD37 | protein_coding | tolerated(0.38) | benign(0) | TCGA-91-6849-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
KIAA1109 | SNV | Missense_Mutation | c.6411G>T | p.Lys2137Asn | p.K2137N | Q2LD37 | protein_coding | deleterious(0) | benign(0.343) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIAA1109 | SNV | Missense_Mutation | c.4251A>T | p.Lys1417Asn | p.K1417N | Q2LD37 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KIAA1109 | SNV | Missense_Mutation | c.10975A>G | p.Thr3659Ala | p.T3659A | Q2LD37 | protein_coding | tolerated(0.07) | probably_damaging(0.97) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KIAA1109 | SNV | Missense_Mutation | c.8136N>G | p.Phe2712Leu | p.F2712L | Q2LD37 | protein_coding | tolerated(1) | probably_damaging(0.952) | TCGA-95-7948-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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