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Gene: ZNF90 |
Gene summary for ZNF90 |
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Gene information | Species | Human | Gene symbol | ZNF90 | Gene ID | 7643 |
Gene name | zinc finger protein 90 | |
Gene Alias | HTF9 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q03938 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7643 | ZNF90 | GSM4909281 | Human | Breast | IDC | 5.60e-21 | 5.29e-01 | 0.21 |
7643 | ZNF90 | GSM4909311 | Human | Breast | IDC | 8.34e-04 | -9.27e-02 | 0.1534 |
7643 | ZNF90 | GSM4909319 | Human | Breast | IDC | 8.07e-06 | -1.15e-01 | 0.1563 |
7643 | ZNF90 | GSM4909320 | Human | Breast | IDC | 4.52e-08 | 5.89e-01 | 0.1575 |
7643 | ZNF90 | GSM4909321 | Human | Breast | IDC | 1.46e-06 | 2.87e-01 | 0.1559 |
7643 | ZNF90 | DCIS2 | Human | Breast | DCIS | 2.19e-03 | -8.95e-02 | 0.0085 |
7643 | ZNF90 | EEC-subject2 | Human | Endometrium | EEC | 3.98e-03 | -1.25e-01 | -0.2607 |
7643 | ZNF90 | EEC-subject3 | Human | Endometrium | EEC | 1.09e-10 | -1.30e-01 | -0.2525 |
7643 | ZNF90 | EEC-subject5 | Human | Endometrium | EEC | 1.82e-05 | -1.36e-01 | -0.249 |
7643 | ZNF90 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.14e-50 | 1.21e+00 | -0.1869 |
7643 | ZNF90 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.60e-52 | 1.28e+00 | -0.1875 |
7643 | ZNF90 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.61e-70 | 1.41e+00 | -0.1883 |
7643 | ZNF90 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.35e-35 | 8.85e-01 | -0.1934 |
7643 | ZNF90 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.20e-61 | 1.17e+00 | -0.1917 |
7643 | ZNF90 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.80e-49 | 1.07e+00 | -0.1916 |
7643 | ZNF90 | S41 | Human | Liver | Cirrhotic | 1.99e-06 | -7.80e-01 | -0.0343 |
7643 | ZNF90 | S42 | Human | Liver | HCC | 1.07e-02 | -6.48e-01 | -0.0103 |
7643 | ZNF90 | S43 | Human | Liver | Cirrhotic | 6.77e-38 | -7.67e-01 | -0.0187 |
7643 | ZNF90 | S44 | Human | Liver | HCC | 2.02e-02 | -7.80e-01 | -0.0083 |
7643 | ZNF90 | HCC1_Meng | Human | Liver | HCC | 7.20e-36 | -7.70e-01 | 0.0246 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF90 | SNV | Missense_Mutation | c.830N>A | p.Arg277Lys | p.R277K | Q03938 | protein_coding | tolerated(0.37) | benign(0.042) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF90 | SNV | Missense_Mutation | c.380N>G | p.Lys127Arg | p.K127R | Q03938 | protein_coding | tolerated(0.08) | benign(0.212) | TCGA-EI-6508-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
ZNF90 | deletion | Frame_Shift_Del | rs781940988 | c.339delN | p.Gly116ValfsTer22 | p.G116Vfs*22 | Q03938 | protein_coding | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF90 | SNV | Missense_Mutation | rs781963081 | c.1069C>T | p.Arg357Cys | p.R357C | Q03938 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF90 | SNV | Missense_Mutation | novel | c.1255C>A | p.His419Asn | p.H419N | Q03938 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF90 | SNV | Missense_Mutation | rs186928119 | c.1601N>T | p.Ala534Val | p.A534V | Q03938 | protein_coding | deleterious(0.02) | benign(0.111) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF90 | SNV | Missense_Mutation | novel | c.762G>T | p.Glu254Asp | p.E254D | Q03938 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF90 | SNV | Missense_Mutation | novel | c.1025A>C | p.Lys342Thr | p.K342T | Q03938 | protein_coding | tolerated(0.06) | possibly_damaging(0.795) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF90 | SNV | Missense_Mutation | novel | c.1350G>T | p.Glu450Asp | p.E450D | Q03938 | protein_coding | deleterious(0.03) | possibly_damaging(0.766) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF90 | SNV | Missense_Mutation | novel | c.1350G>T | p.Glu450Asp | p.E450D | Q03938 | protein_coding | deleterious(0.03) | possibly_damaging(0.766) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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