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Gene: ZNF710 |
Gene summary for ZNF710 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF710 | Gene ID | 374655 |
Gene name | zinc finger protein 710 | |
Gene Alias | ZNF710 | |
Cytomap | 15q26.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N1W2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374655 | ZNF710 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.26e-04 | -3.98e-01 | 0.0155 |
374655 | ZNF710 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.41e-08 | -4.51e-01 | 0.294 |
374655 | ZNF710 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.91e-08 | -4.73e-01 | 0.3859 |
374655 | ZNF710 | F007 | Human | Colorectum | FAP | 4.14e-04 | -3.45e-01 | 0.1176 |
374655 | ZNF710 | A001-C-207 | Human | Colorectum | FAP | 2.65e-02 | -2.33e-01 | 0.1278 |
374655 | ZNF710 | A015-C-203 | Human | Colorectum | FAP | 3.21e-21 | -3.82e-01 | -0.1294 |
374655 | ZNF710 | A015-C-204 | Human | Colorectum | FAP | 6.93e-04 | -3.23e-01 | -0.0228 |
374655 | ZNF710 | A014-C-040 | Human | Colorectum | FAP | 3.82e-05 | -6.12e-01 | -0.1184 |
374655 | ZNF710 | A002-C-201 | Human | Colorectum | FAP | 3.18e-11 | -4.14e-01 | 0.0324 |
374655 | ZNF710 | A001-C-119 | Human | Colorectum | FAP | 9.01e-05 | -2.85e-01 | -0.1557 |
374655 | ZNF710 | A001-C-108 | Human | Colorectum | FAP | 1.26e-12 | -3.37e-01 | -0.0272 |
374655 | ZNF710 | A002-C-205 | Human | Colorectum | FAP | 3.46e-17 | -3.85e-01 | -0.1236 |
374655 | ZNF710 | A015-C-005 | Human | Colorectum | FAP | 3.08e-04 | -2.98e-01 | -0.0336 |
374655 | ZNF710 | A015-C-006 | Human | Colorectum | FAP | 4.93e-15 | -5.42e-01 | -0.0994 |
374655 | ZNF710 | A015-C-106 | Human | Colorectum | FAP | 1.75e-11 | -3.83e-01 | -0.0511 |
374655 | ZNF710 | A002-C-114 | Human | Colorectum | FAP | 1.62e-17 | -5.41e-01 | -0.1561 |
374655 | ZNF710 | A015-C-104 | Human | Colorectum | FAP | 1.46e-21 | -4.28e-01 | -0.1899 |
374655 | ZNF710 | A001-C-014 | Human | Colorectum | FAP | 3.86e-12 | -3.67e-01 | 0.0135 |
374655 | ZNF710 | A002-C-016 | Human | Colorectum | FAP | 7.72e-19 | -4.28e-01 | 0.0521 |
374655 | ZNF710 | A015-C-002 | Human | Colorectum | FAP | 1.48e-11 | -4.73e-01 | -0.0763 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF710 | SNV | Missense_Mutation | c.193N>A | p.Asp65Asn | p.D65N | Q8N1W2 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF710 | SNV | Missense_Mutation | novel | c.305C>A | p.Pro102His | p.P102H | Q8N1W2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF710 | SNV | Missense_Mutation | c.68C>T | p.Ala23Val | p.A23V | Q8N1W2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF710 | SNV | Missense_Mutation | rs768322041 | c.463G>A | p.Ala155Thr | p.A155T | Q8N1W2 | protein_coding | tolerated_low_confidence(0.16) | benign(0.003) | TCGA-EC-A24G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZNF710 | SNV | Missense_Mutation | rs138036907 | c.1673G>A | p.Arg558His | p.R558H | Q8N1W2 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF710 | SNV | Missense_Mutation | novel | c.1846N>T | p.Gly616Cys | p.G616C | Q8N1W2 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.829) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF710 | SNV | Missense_Mutation | novel | c.1378N>A | p.Val460Met | p.V460M | Q8N1W2 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ZNF710 | SNV | Missense_Mutation | rs766678203 | c.1903N>A | p.Ala635Thr | p.A635T | Q8N1W2 | protein_coding | tolerated(0.1) | benign(0) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ZNF710 | insertion | Frame_Shift_Ins | novel | c.1386_1387insTTCGTGTGCA | p.Thr466IlefsTer5 | p.T466Ifs*5 | Q8N1W2 | protein_coding | TCGA-EY-A1G7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ZNF710 | SNV | Missense_Mutation | rs753434936 | c.793N>T | p.Arg265Cys | p.R265C | Q8N1W2 | protein_coding | deleterious_low_confidence(0) | benign(0.183) | TCGA-BC-A5W4-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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