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Gene: ZNF708 |
Gene summary for ZNF708 |
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Gene information | Species | Human | Gene symbol | ZNF708 | Gene ID | 7562 |
Gene name | zinc finger protein 708 | |
Gene Alias | KOX8 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17019 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7562 | ZNF708 | male-WTA | Human | Thyroid | PTC | 1.88e-07 | 9.80e-02 | 0.1037 |
7562 | ZNF708 | PTC01 | Human | Thyroid | PTC | 3.99e-07 | 1.00e-01 | 0.1899 |
7562 | ZNF708 | PTC03 | Human | Thyroid | PTC | 1.12e-04 | 1.90e-01 | 0.1784 |
7562 | ZNF708 | PTC04 | Human | Thyroid | PTC | 1.60e-06 | 1.90e-01 | 0.1927 |
7562 | ZNF708 | PTC05 | Human | Thyroid | PTC | 7.45e-13 | 4.72e-01 | 0.2065 |
7562 | ZNF708 | PTC06 | Human | Thyroid | PTC | 3.33e-21 | 4.97e-01 | 0.2057 |
7562 | ZNF708 | PTC07 | Human | Thyroid | PTC | 2.52e-15 | 2.43e-01 | 0.2044 |
7562 | ZNF708 | ATC12 | Human | Thyroid | ATC | 9.15e-06 | 6.65e-02 | 0.34 |
7562 | ZNF708 | ATC13 | Human | Thyroid | ATC | 9.13e-46 | 8.83e-01 | 0.34 |
7562 | ZNF708 | ATC2 | Human | Thyroid | ATC | 8.21e-06 | 5.44e-01 | 0.34 |
7562 | ZNF708 | ATC4 | Human | Thyroid | ATC | 3.91e-04 | 8.99e-02 | 0.34 |
7562 | ZNF708 | ATC5 | Human | Thyroid | ATC | 2.70e-51 | 9.39e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF708 | SNV | Missense_Mutation | rs757386413 | c.952N>G | p.Thr318Ala | p.T318A | P17019 | protein_coding | deleterious(0.05) | benign(0.251) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF708 | SNV | Missense_Mutation | rs760773229 | c.1655G>T | p.Arg552Ile | p.R552I | P17019 | protein_coding | tolerated(0.45) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF708 | SNV | Missense_Mutation | novel | c.1412C>T | p.Thr471Ile | p.T471I | P17019 | protein_coding | deleterious(0.02) | probably_damaging(0.943) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF708 | SNV | Missense_Mutation | novel | c.869A>G | p.Lys290Arg | p.K290R | P17019 | protein_coding | tolerated(0.17) | benign(0.222) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF708 | SNV | Missense_Mutation | c.1388N>G | p.Phe463Cys | p.F463C | P17019 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
ZNF708 | SNV | Missense_Mutation | rs760773229 | c.1655N>T | p.Arg552Ile | p.R552I | P17019 | protein_coding | tolerated(0.45) | benign(0) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
ZNF708 | SNV | Missense_Mutation | c.278A>C | p.Asn93Thr | p.N93T | P17019 | protein_coding | deleterious(0.03) | benign(0.065) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF708 | SNV | Missense_Mutation | novel | c.758N>C | p.Lys253Thr | p.K253T | P17019 | protein_coding | tolerated(0.08) | possibly_damaging(0.838) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF708 | SNV | Missense_Mutation | novel | c.493N>C | p.Lys165Gln | p.K165Q | P17019 | protein_coding | deleterious(0.04) | possibly_damaging(0.648) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF708 | SNV | Missense_Mutation | c.281N>A | p.Ser94Tyr | p.S94Y | P17019 | protein_coding | tolerated(0.06) | benign(0.033) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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