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Gene: ZNF665 |
Gene summary for ZNF665 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF665 | Gene ID | 79788 |
| Gene name | zinc finger protein 665 | |
| Gene Alias | ZFP160L | |
| Cytomap | 19q13.42 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H7R5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79788 | ZNF665 | HCC1 | Human | Liver | HCC | 6.03e-10 | 1.35e+00 | 0.5336 |
| 79788 | ZNF665 | HCC2 | Human | Liver | HCC | 6.34e-23 | 1.60e+00 | 0.5341 |
| 79788 | ZNF665 | HCC5 | Human | Liver | HCC | 1.59e-13 | 1.67e+00 | 0.4932 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF665 | CHO | Liver | Cirrhotic | MBD5,MAPK10,GALNT5, etc. | 3.98e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF665 | insertion | Nonsense_Mutation | novel | c.539_540insACC | p.Cys180delinsTer | p.C180delins* | Q9H7R5 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ZNF665 | insertion | Frame_Shift_Ins | novel | c.1647_1648insA | p.Val550SerfsTer18 | p.V550Sfs*18 | Q9H7R5 | protein_coding | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
| ZNF665 | SNV | Missense_Mutation | rs767094244 | c.1093C>T | p.Arg365Trp | p.R365W | Q9H7R5 | protein_coding | tolerated(0.15) | probably_damaging(0.921) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ZNF665 | SNV | Missense_Mutation | rs746630449 | c.761N>T | p.Arg254Ile | p.R254I | Q9H7R5 | protein_coding | deleterious(0.03) | benign(0.304) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF665 | SNV | Missense_Mutation | novel | c.583N>C | p.Ser195Arg | p.S195R | Q9H7R5 | protein_coding | tolerated(0.39) | benign(0.174) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF665 | SNV | Missense_Mutation | rs545877487 | c.215N>T | p.Thr72Met | p.T72M | Q9H7R5 | protein_coding | deleterious(0.05) | benign(0.075) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF665 | SNV | Missense_Mutation | novel | c.1059G>T | p.Lys353Asn | p.K353N | Q9H7R5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| ZNF665 | SNV | Missense_Mutation | novel | c.1928C>T | p.Thr643Ile | p.T643I | Q9H7R5 | protein_coding | tolerated(0.48) | benign(0.063) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF665 | SNV | Missense_Mutation | c.4N>A | p.Ala2Thr | p.A2T | Q9H7R5 | protein_coding | deleterious(0.02) | possibly_damaging(0.634) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF665 | SNV | Missense_Mutation | c.359N>G | p.Leu120Arg | p.L120R | Q9H7R5 | protein_coding | deleterious(0) | benign(0.124) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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