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Gene: ZNF662 |
Gene summary for ZNF662 |
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Gene information | Species | Human | Gene symbol | ZNF662 | Gene ID | 389114 |
Gene name | zinc finger protein 662 | |
Gene Alias | ZNF662 | |
Cytomap | 3p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZS27 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389114 | ZNF662 | HCC1 | Human | Liver | HCC | 2.20e-11 | 1.32e+00 | 0.5336 |
389114 | ZNF662 | HCC2 | Human | Liver | HCC | 3.44e-15 | 1.83e+00 | 0.5341 |
389114 | ZNF662 | HCC5 | Human | Liver | HCC | 2.00e-12 | 1.45e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF662 | SNV | Missense_Mutation | c.1217N>T | p.Arg406Ile | p.R406I | Q6ZS27 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | rs762407731 | c.797N>T | p.Arg266Ile | p.R266I | Q6ZS27 | protein_coding | tolerated(0.13) | benign(0.071) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | c.358N>T | p.Asp120Tyr | p.D120Y | Q6ZS27 | protein_coding | deleterious(0) | benign(0.015) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | c.881N>T | p.Arg294Ile | p.R294I | Q6ZS27 | protein_coding | deleterious(0) | possibly_damaging(0.534) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | c.1217G>T | p.Arg406Ile | p.R406I | Q6ZS27 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | rs762407731 | c.797N>T | p.Arg266Ile | p.R266I | Q6ZS27 | protein_coding | tolerated(0.13) | benign(0.071) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | novel | c.940A>C | p.Asn314His | p.N314H | Q6ZS27 | protein_coding | deleterious(0) | possibly_damaging(0.865) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | c.590N>A | p.Gly197Glu | p.G197E | Q6ZS27 | protein_coding | tolerated(1) | benign(0) | TCGA-E6-A1LZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
ZNF662 | SNV | Missense_Mutation | novel | c.244N>G | p.Ile82Val | p.I82V | Q6ZS27 | protein_coding | tolerated(0.15) | probably_damaging(0.978) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | novel | c.1088N>A | p.Cys363Tyr | p.C363Y | Q6ZS27 | protein_coding | deleterious(0.01) | possibly_damaging(0.904) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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