TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF557 | BN | Liver | Cirrhotic | LINC01138,TKT,CHST12, etc. | 1.09e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_Cirrhotic/regulons_activity_in_dotplot.png) |
ZNF557 | MEGA | Lung | ADJ | TMEM86A,AC147067.1,FLT1, etc. | 3.35e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF557 | FIB | Lung | Healthy | TMEM86A,AC147067.1,FLT1, etc. | 4.45e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF557 | PVA | Lung | Healthy | TMEM86A,AC147067.1,FLT1, etc. | 1.08e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF557 | PVA | Lung | IAC | TMEM86A,AC147067.1,FLT1, etc. | 1.51e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF557 | SNV | Missense_Mutation | | c.31N>T | p.Ala11Ser | p.A11S | Q8N988 | protein_coding | tolerated(0.27) | probably_damaging(0.962) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | | c.872A>G | p.His291Arg | p.H291R | Q8N988 | protein_coding | tolerated(0.09) | benign(0.352) | TCGA-AP-A1DP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PD |
ZNF557 | SNV | Missense_Mutation | rs569224650 | c.811N>T | p.Arg271Cys | p.R271C | Q8N988 | protein_coding | deleterious(0) | benign(0.129) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZNF557 | SNV | Missense_Mutation | novel | c.1103N>T | p.Arg368Ile | p.R368I | Q8N988 | protein_coding | deleterious(0) | possibly_damaging(0.753) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZNF557 | SNV | Missense_Mutation | | c.998N>T | p.Ser333Leu | p.S333L | Q8N988 | protein_coding | tolerated(0.12) | benign(0.062) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | novel | c.439N>A | p.Leu147Ile | p.L147I | Q8N988 | protein_coding | tolerated(0.43) | possibly_damaging(0.556) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ZNF557 | SNV | Missense_Mutation | | c.259G>A | p.Asp87Asn | p.D87N | Q8N988 | protein_coding | tolerated(0.2) | benign(0) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ZNF557 | SNV | Missense_Mutation | rs569224650 | c.811C>T | p.Arg271Cys | p.R271C | Q8N988 | protein_coding | deleterious(0) | benign(0.129) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | novel | c.1181A>G | p.His394Arg | p.H394R | Q8N988 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | novel | c.1210N>C | p.Tyr404His | p.Y404H | Q8N988 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |