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Gene: ZNF552 |
Gene summary for ZNF552 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF552 | Gene ID | 79818 |
Gene name | zinc finger protein 552 | |
Gene Alias | ZNF552 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H707 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79818 | ZNF552 | GSM4909298 | Human | Breast | IDC | 2.87e-19 | 4.69e-01 | 0.1551 |
79818 | ZNF552 | GSM4909301 | Human | Breast | IDC | 6.41e-30 | 7.99e-01 | 0.1577 |
79818 | ZNF552 | GSM4909302 | Human | Breast | IDC | 2.43e-25 | 7.01e-01 | 0.1545 |
79818 | ZNF552 | GSM4909307 | Human | Breast | IDC | 4.59e-04 | 3.15e-01 | 0.1569 |
79818 | ZNF552 | GSM4909308 | Human | Breast | IDC | 1.39e-29 | 6.32e-01 | 0.158 |
79818 | ZNF552 | GSM4909311 | Human | Breast | IDC | 1.58e-04 | 8.11e-02 | 0.1534 |
79818 | ZNF552 | GSM4909319 | Human | Breast | IDC | 9.44e-18 | 3.98e-01 | 0.1563 |
79818 | ZNF552 | GSM4909321 | Human | Breast | IDC | 4.33e-02 | 1.74e-01 | 0.1559 |
79818 | ZNF552 | M1 | Human | Breast | IDC | 4.20e-17 | 5.78e-01 | 0.1577 |
79818 | ZNF552 | M5 | Human | Breast | IDC | 1.06e-05 | 6.54e-01 | 0.1598 |
79818 | ZNF552 | DCIS2 | Human | Breast | DCIS | 5.09e-13 | -1.95e-02 | 0.0085 |
79818 | ZNF552 | LZE5T | Human | Esophagus | ESCC | 1.57e-03 | 3.46e-01 | 0.0514 |
79818 | ZNF552 | LZE21D1 | Human | Esophagus | HGIN | 3.53e-05 | 3.46e-01 | 0.0632 |
79818 | ZNF552 | LZE24T | Human | Esophagus | ESCC | 7.06e-21 | 4.28e-01 | 0.0596 |
79818 | ZNF552 | P1T-E | Human | Esophagus | ESCC | 7.43e-09 | 3.48e-01 | 0.0875 |
79818 | ZNF552 | P5T-E | Human | Esophagus | ESCC | 4.40e-05 | 5.67e-02 | 0.1327 |
79818 | ZNF552 | P8T-E | Human | Esophagus | ESCC | 1.08e-09 | 1.41e-01 | 0.0889 |
79818 | ZNF552 | P10T-E | Human | Esophagus | ESCC | 5.15e-12 | 2.23e-01 | 0.116 |
79818 | ZNF552 | P11T-E | Human | Esophagus | ESCC | 2.10e-10 | 2.92e-01 | 0.1426 |
79818 | ZNF552 | P12T-E | Human | Esophagus | ESCC | 8.89e-07 | 9.82e-02 | 0.1122 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF552 | SNV | Missense_Mutation | c.639N>A | p.Ser213Arg | p.S213R | Q9H707 | protein_coding | tolerated(0.35) | benign(0.015) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF552 | SNV | Missense_Mutation | c.1022N>A | p.Val341Asp | p.V341D | Q9H707 | protein_coding | tolerated(0.11) | benign(0.216) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF552 | SNV | Missense_Mutation | rs576029108 | c.470N>T | p.Ala157Val | p.A157V | Q9H707 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF552 | SNV | Missense_Mutation | c.497N>T | p.Gly166Val | p.G166V | Q9H707 | protein_coding | tolerated(0.05) | possibly_damaging(0.495) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF552 | SNV | Missense_Mutation | c.1075N>C | p.Lys359Gln | p.K359Q | Q9H707 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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