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Gene: ZNF512 |
Gene summary for ZNF512 |
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Gene information | Species | Human | Gene symbol | ZNF512 | Gene ID | 84450 |
Gene name | zinc finger protein 512 | |
Gene Alias | ZNF512 | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96ME7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84450 | ZNF512 | HCC1_Meng | Human | Liver | HCC | 6.23e-42 | 2.51e-02 | 0.0246 |
84450 | ZNF512 | HCC2_Meng | Human | Liver | HCC | 6.91e-04 | 1.25e-02 | 0.0107 |
84450 | ZNF512 | HCC1 | Human | Liver | HCC | 2.59e-04 | 3.70e+00 | 0.5336 |
84450 | ZNF512 | HCC2 | Human | Liver | HCC | 8.70e-04 | 2.20e+00 | 0.5341 |
84450 | ZNF512 | Pt13.b | Human | Liver | HCC | 2.10e-02 | 2.43e-02 | 0.0251 |
84450 | ZNF512 | S014 | Human | Liver | HCC | 1.45e-03 | 1.61e-01 | 0.2254 |
84450 | ZNF512 | S027 | Human | Liver | HCC | 2.68e-02 | 3.42e-01 | 0.2446 |
84450 | ZNF512 | S028 | Human | Liver | HCC | 1.43e-11 | 4.77e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF512 | SNV | Missense_Mutation | rs757452769 | c.620N>A | p.Arg207His | p.R207H | Q96ME7 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-D1-A17M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF512 | SNV | Missense_Mutation | c.733C>A | p.Leu245Ile | p.L245I | Q96ME7 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF512 | SNV | Missense_Mutation | c.386N>A | p.Arg129Gln | p.R129Q | Q96ME7 | protein_coding | tolerated(0.52) | benign(0.028) | TCGA-D1-A1O7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF512 | SNV | Missense_Mutation | novel | c.1246N>A | p.Val416Ile | p.V416I | Q96ME7 | protein_coding | tolerated(0.41) | benign(0.366) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF512 | SNV | Missense_Mutation | novel | c.496N>G | p.Lys166Glu | p.K166E | Q96ME7 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ZNF512 | SNV | Missense_Mutation | novel | c.457N>T | p.Gly153Cys | p.G153C | Q96ME7 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF512 | SNV | Missense_Mutation | novel | c.87G>T | p.Lys29Asn | p.K29N | Q96ME7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.981) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ZNF512 | SNV | Missense_Mutation | novel | c.707G>T | p.Ser236Ile | p.S236I | Q96ME7 | protein_coding | tolerated(0.12) | benign(0.006) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF512 | SNV | Missense_Mutation | novel | c.430C>T | p.Arg144Trp | p.R144W | Q96ME7 | protein_coding | deleterious(0) | possibly_damaging(0.644) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF512 | SNV | Missense_Mutation | novel | c.457G>T | p.Gly153Cys | p.G153C | Q96ME7 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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