Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ZNF410_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZNF410_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ZNF410_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF410 | PLA | Breast | Healthy | GPRC5A,NPM3,AC092803.2, etc. | 1.05e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF410 | PLA | Breast | IDC | GPRC5A,NPM3,AC092803.2, etc. | 1.39e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_IDC/regulons_activity_in_dotplot.png) |
ZNF410 | CD8TEXP | Breast | IDC | GPRC5A,NPM3,AC092803.2, etc. | 5.14e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_IDC/regulons_activity_in_dotplot.png) |
ZNF410 | PLA | Breast | Precancer | GPRC5A,NPM3,AC092803.2, etc. | 1.28e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF410 | SNV | Missense_Mutation | novel | c.728N>T | p.Cys243Phe | p.C243F | Q86VK4 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-77-A5G6-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZNF410 | SNV | Missense_Mutation | rs769091601 | c.317N>T | p.Thr106Met | p.T106M | Q86VK4 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.996) | TCGA-94-A4VJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF410 | deletion | Frame_Shift_Del | novel | c.97_101delGCTAA | p.Ala33ArgfsTer12 | p.A33Rfs*12 | Q86VK4 | protein_coding | | | TCGA-37-A5EL-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | temodal | PD |
ZNF410 | SNV | Missense_Mutation | novel | c.67C>T | p.Pro23Ser | p.P23S | Q86VK4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.993) | TCGA-CV-A6JD-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | | c.634N>A | p.Glu212Lys | p.E212K | Q86VK4 | protein_coding | deleterious(0.05) | probably_damaging(0.968) | TCGA-CH-5754-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | novel | c.915N>T | p.Lys305Asn | p.K305N | Q86VK4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ZNF410 | SNV | Missense_Mutation | | c.953N>A | p.Arg318His | p.R318H | Q86VK4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | novel | c.103N>T | p.Asp35Tyr | p.D35Y | Q86VK4 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.998) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | | Complete Response |
ZNF410 | SNV | Missense_Mutation | | c.1447N>C | p.Glu483Gln | p.E483Q | Q86VK4 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(0.954) | TCGA-EL-A3H1-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF410 | insertion | Frame_Shift_Ins | novel | c.618_619insTATATGAAAAGTT | p.Thr207TyrfsTer18 | p.T207Yfs*18 | Q86VK4 | protein_coding | | | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |