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Gene: ZNF28 |
Gene summary for ZNF28 |
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Gene information | Species | Human | Gene symbol | ZNF28 | Gene ID | 7576 |
Gene name | zinc finger protein 28 | |
Gene Alias | KOX24 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17035 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7576 | ZNF28 | HCC1_Meng | Human | Liver | HCC | 2.43e-48 | 6.36e-02 | 0.0246 |
7576 | ZNF28 | HCC1 | Human | Liver | HCC | 1.50e-02 | 2.64e+00 | 0.5336 |
7576 | ZNF28 | HCC2 | Human | Liver | HCC | 3.70e-08 | 2.41e+00 | 0.5341 |
7576 | ZNF28 | S015 | Human | Liver | HCC | 5.56e-06 | 2.53e-01 | 0.2375 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
GO:00101711 | Esophagus | ESCC | body morphogenesis | 30/8552 | 43/18723 | 1.21e-03 | 5.88e-03 | 30 |
GO:004886311 | Liver | Cirrhotic | stem cell differentiation | 66/4634 | 206/18723 | 1.06e-02 | 4.68e-02 | 66 |
GO:00488637 | Oral cavity | OSCC | stem cell differentiation | 96/7305 | 206/18723 | 1.55e-02 | 4.99e-02 | 96 |
GO:00101713 | Thyroid | PTC | body morphogenesis | 23/5968 | 43/18723 | 2.66e-03 | 1.35e-02 | 23 |
GO:004886318 | Thyroid | PTC | stem cell differentiation | 85/5968 | 206/18723 | 2.71e-03 | 1.36e-02 | 85 |
GO:001017111 | Thyroid | ATC | body morphogenesis | 28/6293 | 43/18723 | 2.35e-05 | 2.06e-04 | 28 |
GO:004886321 | Thyroid | ATC | stem cell differentiation | 97/6293 | 206/18723 | 3.88e-05 | 3.15e-04 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF28 | SNV | Missense_Mutation | novel | c.1735N>C | p.Tyr579His | p.Y579H | P17035 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF28 | SNV | Missense_Mutation | rs550046697 | c.1115N>A | p.Arg372His | p.R372H | P17035 | protein_coding | tolerated(0.12) | possibly_damaging(0.489) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF28 | SNV | Missense_Mutation | c.500N>A | p.Ser167Tyr | p.S167Y | P17035 | protein_coding | deleterious(0) | possibly_damaging(0.735) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF28 | SNV | Missense_Mutation | novel | c.636N>C | p.Glu212Asp | p.E212D | P17035 | protein_coding | deleterious(0.03) | probably_damaging(0.931) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZNF28 | SNV | Missense_Mutation | c.1476N>T | p.Glu492Asp | p.E492D | P17035 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
ZNF28 | SNV | Missense_Mutation | rs763030309 | c.1181N>A | p.Arg394His | p.R394H | P17035 | protein_coding | tolerated(0.55) | probably_damaging(0.992) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ZNF28 | SNV | Missense_Mutation | novel | c.697N>T | p.His233Tyr | p.H233Y | P17035 | protein_coding | deleterious(0.03) | possibly_damaging(0.838) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ZNF28 | SNV | Missense_Mutation | novel | c.596N>A | p.Ser199Tyr | p.S199Y | P17035 | protein_coding | tolerated(0.21) | probably_damaging(0.974) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ZNF28 | SNV | Missense_Mutation | novel | c.645N>A | p.Phe215Leu | p.F215L | P17035 | protein_coding | deleterious(0) | possibly_damaging(0.878) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF28 | SNV | Missense_Mutation | c.1392N>T | p.Glu464Asp | p.E464D | P17035 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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