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Gene: ZNF275 |
Gene summary for ZNF275 |
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Gene information | Species | Human | Gene symbol | ZNF275 | Gene ID | 10838 |
Gene name | zinc finger protein 275 | |
Gene Alias | ZNF275 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A6NFS0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10838 | ZNF275 | HCC1_Meng | Human | Liver | HCC | 5.33e-39 | 8.40e-02 | 0.0246 |
10838 | ZNF275 | HCC2_Meng | Human | Liver | HCC | 1.18e-15 | 1.39e-01 | 0.0107 |
10838 | ZNF275 | HCC2 | Human | Liver | HCC | 7.25e-05 | 3.01e+00 | 0.5341 |
10838 | ZNF275 | S027 | Human | Liver | HCC | 8.20e-08 | 8.23e-01 | 0.2446 |
10838 | ZNF275 | S028 | Human | Liver | HCC | 8.54e-23 | 8.12e-01 | 0.2503 |
10838 | ZNF275 | S029 | Human | Liver | HCC | 3.50e-19 | 8.25e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF275 | SNV | Missense_Mutation | c.929A>C | p.Lys310Thr | p.K310T | protein_coding | deleterious(0.04) | probably_damaging(0.909) | TCGA-D1-A101-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF275 | SNV | Missense_Mutation | c.325N>G | p.Thr109Ala | p.T109A | protein_coding | tolerated(0.78) | benign(0.003) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF275 | SNV | Missense_Mutation | novel | c.25N>T | p.Leu9Phe | p.L9F | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF275 | SNV | Missense_Mutation | novel | c.251N>G | p.Asp84Gly | p.D84G | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
ZNF275 | SNV | Missense_Mutation | novel | c.551N>G | p.Glu184Gly | p.E184G | protein_coding | tolerated(0.06) | benign(0.022) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
ZNF275 | SNV | Missense_Mutation | novel | c.862N>G | p.Ser288Gly | p.S288G | protein_coding | deleterious(0.05) | benign(0.006) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
ZNF275 | SNV | Missense_Mutation | c.397N>A | p.Asp133Asn | p.D133N | protein_coding | deleterious(0.01) | possibly_damaging(0.642) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF275 | SNV | Missense_Mutation | rs782458088 | c.835G>A | p.Gly279Arg | p.G279R | protein_coding | deleterious(0.03) | probably_damaging(0.962) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF275 | SNV | Missense_Mutation | novel | c.329N>G | p.Phe110Cys | p.F110C | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
ZNF275 | SNV | Missense_Mutation | rs782741956 | c.698N>T | p.Ser233Leu | p.S233L | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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