![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF251 |
Gene summary for ZNF251 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF251 | Gene ID | 90987 |
Gene name | zinc finger protein 251 | |
Gene Alias | ZNF251 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BRH9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90987 | ZNF251 | LZE20T | Human | Esophagus | ESCC | 9.24e-03 | 8.35e-02 | 0.0662 |
90987 | ZNF251 | LZE24T | Human | Esophagus | ESCC | 2.71e-10 | 2.49e-01 | 0.0596 |
90987 | ZNF251 | P2T-E | Human | Esophagus | ESCC | 6.03e-10 | 1.42e-01 | 0.1177 |
90987 | ZNF251 | P4T-E | Human | Esophagus | ESCC | 1.55e-05 | 1.14e-01 | 0.1323 |
90987 | ZNF251 | P5T-E | Human | Esophagus | ESCC | 3.13e-02 | 1.10e-01 | 0.1327 |
90987 | ZNF251 | P8T-E | Human | Esophagus | ESCC | 9.03e-10 | 1.37e-01 | 0.0889 |
90987 | ZNF251 | P9T-E | Human | Esophagus | ESCC | 3.06e-04 | 9.97e-02 | 0.1131 |
90987 | ZNF251 | P10T-E | Human | Esophagus | ESCC | 1.74e-09 | 1.20e-01 | 0.116 |
90987 | ZNF251 | P11T-E | Human | Esophagus | ESCC | 1.96e-05 | 2.58e-01 | 0.1426 |
90987 | ZNF251 | P12T-E | Human | Esophagus | ESCC | 1.25e-14 | 1.71e-01 | 0.1122 |
90987 | ZNF251 | P15T-E | Human | Esophagus | ESCC | 5.31e-05 | 1.10e-01 | 0.1149 |
90987 | ZNF251 | P16T-E | Human | Esophagus | ESCC | 7.72e-09 | 2.46e-01 | 0.1153 |
90987 | ZNF251 | P20T-E | Human | Esophagus | ESCC | 3.50e-09 | 2.20e-01 | 0.1124 |
90987 | ZNF251 | P21T-E | Human | Esophagus | ESCC | 2.53e-07 | 8.79e-02 | 0.1617 |
90987 | ZNF251 | P22T-E | Human | Esophagus | ESCC | 3.29e-04 | 6.65e-02 | 0.1236 |
90987 | ZNF251 | P23T-E | Human | Esophagus | ESCC | 1.14e-09 | 2.27e-01 | 0.108 |
90987 | ZNF251 | P24T-E | Human | Esophagus | ESCC | 2.38e-05 | 5.64e-02 | 0.1287 |
90987 | ZNF251 | P26T-E | Human | Esophagus | ESCC | 2.57e-38 | 6.25e-01 | 0.1276 |
90987 | ZNF251 | P27T-E | Human | Esophagus | ESCC | 5.65e-09 | 1.21e-01 | 0.1055 |
90987 | ZNF251 | P28T-E | Human | Esophagus | ESCC | 4.35e-07 | 1.58e-01 | 0.1149 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF251 | PLA | Endometrium | Healthy | SPATS2L,PHKA2,RAB7A, etc. | 2.58e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF251 | SNV | Missense_Mutation | novel | c.1154N>T | p.Ala385Val | p.A385V | Q9BRH9 | protein_coding | tolerated(0.05) | benign(0.036) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ZNF251 | SNV | Missense_Mutation | c.854N>T | p.Arg285Ile | p.R285I | Q9BRH9 | protein_coding | deleterious(0.02) | possibly_damaging(0.902) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
ZNF251 | SNV | Missense_Mutation | novel | c.686N>T | p.Arg229Ile | p.R229I | Q9BRH9 | protein_coding | deleterious(0.04) | possibly_damaging(0.566) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ZNF251 | SNV | Missense_Mutation | novel | c.724N>G | p.Cys242Gly | p.C242G | Q9BRH9 | protein_coding | deleterious(0) | benign(0.14) | TCGA-AX-A0IS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ZNF251 | SNV | Missense_Mutation | novel | c.764N>G | p.His255Arg | p.H255R | Q9BRH9 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ZNF251 | SNV | Missense_Mutation | rs777430092 | c.1331G>A | p.Arg444Gln | p.R444Q | Q9BRH9 | protein_coding | tolerated(0.45) | benign(0.037) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF251 | SNV | Missense_Mutation | novel | c.1193N>C | p.Val398Ala | p.V398A | Q9BRH9 | protein_coding | deleterious(0.01) | possibly_damaging(0.506) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF251 | SNV | Missense_Mutation | c.83N>T | p.Glu28Val | p.E28V | Q9BRH9 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-B5-A11G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF251 | SNV | Missense_Mutation | novel | c.325T>G | p.Phe109Val | p.F109V | Q9BRH9 | protein_coding | tolerated(0.44) | benign(0) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF251 | SNV | Missense_Mutation | rs761041427 | c.1295N>T | p.Pro432Leu | p.P432L | Q9BRH9 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |