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Gene: ZNF250 |
Gene summary for ZNF250 |
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Gene information | Species | Human | Gene symbol | ZNF250 | Gene ID | 58500 |
Gene name | zinc finger protein 250 | |
Gene Alias | ZFP647 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KNS9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58500 | ZNF250 | LZE4T | Human | Esophagus | ESCC | 1.60e-06 | 1.52e-01 | 0.0811 |
58500 | ZNF250 | LZE8T | Human | Esophagus | ESCC | 4.24e-03 | 1.12e-01 | 0.067 |
58500 | ZNF250 | LZE20T | Human | Esophagus | ESCC | 3.73e-03 | 1.10e-01 | 0.0662 |
58500 | ZNF250 | LZE24T | Human | Esophagus | ESCC | 5.64e-10 | 2.12e-01 | 0.0596 |
58500 | ZNF250 | P2T-E | Human | Esophagus | ESCC | 4.65e-13 | 2.24e-01 | 0.1177 |
58500 | ZNF250 | P4T-E | Human | Esophagus | ESCC | 5.13e-05 | 1.29e-01 | 0.1323 |
58500 | ZNF250 | P5T-E | Human | Esophagus | ESCC | 5.56e-04 | 6.93e-02 | 0.1327 |
58500 | ZNF250 | P8T-E | Human | Esophagus | ESCC | 6.39e-04 | 1.08e-01 | 0.0889 |
58500 | ZNF250 | P9T-E | Human | Esophagus | ESCC | 1.96e-06 | 1.01e-01 | 0.1131 |
58500 | ZNF250 | P10T-E | Human | Esophagus | ESCC | 1.54e-10 | 2.17e-01 | 0.116 |
58500 | ZNF250 | P11T-E | Human | Esophagus | ESCC | 2.38e-04 | 2.45e-01 | 0.1426 |
58500 | ZNF250 | P12T-E | Human | Esophagus | ESCC | 1.10e-17 | 3.63e-01 | 0.1122 |
58500 | ZNF250 | P15T-E | Human | Esophagus | ESCC | 1.90e-07 | 1.60e-01 | 0.1149 |
58500 | ZNF250 | P16T-E | Human | Esophagus | ESCC | 8.73e-16 | 3.00e-01 | 0.1153 |
58500 | ZNF250 | P20T-E | Human | Esophagus | ESCC | 6.30e-12 | 2.05e-01 | 0.1124 |
58500 | ZNF250 | P21T-E | Human | Esophagus | ESCC | 5.43e-08 | 1.47e-01 | 0.1617 |
58500 | ZNF250 | P22T-E | Human | Esophagus | ESCC | 1.23e-03 | 1.15e-01 | 0.1236 |
58500 | ZNF250 | P23T-E | Human | Esophagus | ESCC | 1.92e-10 | 2.42e-01 | 0.108 |
58500 | ZNF250 | P24T-E | Human | Esophagus | ESCC | 3.37e-04 | 1.28e-01 | 0.1287 |
58500 | ZNF250 | P26T-E | Human | Esophagus | ESCC | 5.51e-28 | 5.08e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF250 | SNV | Missense_Mutation | rs368254797 | c.1297N>A | p.Val433Ile | p.V433I | P15622 | protein_coding | tolerated(0.06) | possibly_damaging(0.589) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF250 | SNV | Missense_Mutation | novel | c.1219N>T | p.Arg407Cys | p.R407C | P15622 | protein_coding | tolerated(0.19) | possibly_damaging(0.517) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF250 | SNV | Missense_Mutation | novel | c.1516N>T | p.Pro506Ser | p.P506S | P15622 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-QS-A5YR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF250 | SNV | Missense_Mutation | novel | c.1489C>A | p.His497Asn | p.H497N | P15622 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-DD-AAD5-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZNF250 | SNV | Missense_Mutation | novel | c.583N>A | p.Gly195Arg | p.G195R | P15622 | protein_coding | tolerated(0.09) | possibly_damaging(0.832) | TCGA-RC-A6M6-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF250 | SNV | Missense_Mutation | c.1179N>T | p.Lys393Asn | p.K393N | P15622 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
ZNF250 | SNV | Missense_Mutation | c.1480N>G | p.Leu494Val | p.L494V | P15622 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-50-5936-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD | |
ZNF250 | SNV | Missense_Mutation | novel | c.941C>A | p.Pro314Gln | p.P314Q | P15622 | protein_coding | tolerated(0.26) | possibly_damaging(0.728) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
ZNF250 | SNV | Missense_Mutation | c.7N>T | p.Ala3Ser | p.A3S | P15622 | protein_coding | tolerated(0.14) | possibly_damaging(0.629) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
ZNF250 | SNV | Missense_Mutation | c.929N>A | p.Pro310Gln | p.P310Q | P15622 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-A456-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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