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Gene: ZNF22 |
Gene summary for ZNF22 |
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Gene information | Species | Human | Gene symbol | ZNF22 | Gene ID | 7570 |
Gene name | zinc finger protein 22 | |
Gene Alias | HKR-T1 | |
Cytomap | 10q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R7T4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7570 | ZNF22 | AEH-subject1 | Human | Endometrium | AEH | 2.13e-17 | -4.11e-01 | -0.3059 |
7570 | ZNF22 | AEH-subject2 | Human | Endometrium | AEH | 1.67e-21 | -4.49e-01 | -0.2525 |
7570 | ZNF22 | AEH-subject3 | Human | Endometrium | AEH | 6.53e-16 | -4.06e-01 | -0.2576 |
7570 | ZNF22 | AEH-subject4 | Human | Endometrium | AEH | 4.13e-09 | -3.73e-01 | -0.2657 |
7570 | ZNF22 | AEH-subject5 | Human | Endometrium | AEH | 3.83e-11 | -3.85e-01 | -0.2953 |
7570 | ZNF22 | EEC-subject1 | Human | Endometrium | EEC | 1.60e-18 | -3.95e-01 | -0.2682 |
7570 | ZNF22 | EEC-subject2 | Human | Endometrium | EEC | 1.04e-21 | -4.28e-01 | -0.2607 |
7570 | ZNF22 | EEC-subject3 | Human | Endometrium | EEC | 3.16e-36 | -4.59e-01 | -0.2525 |
7570 | ZNF22 | EEC-subject4 | Human | Endometrium | EEC | 2.71e-14 | -3.80e-01 | -0.2571 |
7570 | ZNF22 | EEC-subject5 | Human | Endometrium | EEC | 9.06e-22 | -4.39e-01 | -0.249 |
7570 | ZNF22 | GSM5276934 | Human | Endometrium | EEC | 9.40e-06 | -2.88e-01 | -0.0913 |
7570 | ZNF22 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.57e-33 | -1.93e-01 | -0.1869 |
7570 | ZNF22 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.66e-29 | -3.27e-01 | -0.1875 |
7570 | ZNF22 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.15e-28 | -4.25e-01 | -0.1883 |
7570 | ZNF22 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.17e-29 | -2.67e-01 | -0.1934 |
7570 | ZNF22 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.44e-33 | -2.58e-01 | -0.1917 |
7570 | ZNF22 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.26e-45 | -3.04e-01 | -0.1916 |
7570 | ZNF22 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 6.50e-09 | -3.08e-01 | -0.1269 |
7570 | ZNF22 | LZE2T | Human | Esophagus | ESCC | 1.71e-05 | 5.62e-01 | 0.082 |
7570 | ZNF22 | LZE4T | Human | Esophagus | ESCC | 2.40e-13 | 3.68e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF22 | SNV | Missense_Mutation | novel | c.593N>T | p.Arg198Leu | p.R198L | P17026 | protein_coding | tolerated(0.19) | benign(0.188) | TCGA-HC-7081-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
ZNF22 | deletion | Frame_Shift_Del | rs774411856 | c.620_623delNNNN | p.Leu208ProfsTer22 | p.L208Pfs*22 | P17026 | protein_coding | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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