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Gene: ZNF195 |
Gene summary for ZNF195 |
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Gene information | Species | Human | Gene symbol | ZNF195 | Gene ID | 7748 |
Gene name | zinc finger protein 195 | |
Gene Alias | HRF1 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O14628 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7748 | ZNF195 | LZE4T | Human | Esophagus | ESCC | 4.64e-03 | 8.30e-02 | 0.0811 |
7748 | ZNF195 | LZE7T | Human | Esophagus | ESCC | 1.77e-05 | 2.32e-01 | 0.0667 |
7748 | ZNF195 | LZE8T | Human | Esophagus | ESCC | 3.42e-04 | 8.68e-02 | 0.067 |
7748 | ZNF195 | LZE20T | Human | Esophagus | ESCC | 7.92e-03 | 6.17e-02 | 0.0662 |
7748 | ZNF195 | LZE24T | Human | Esophagus | ESCC | 3.03e-14 | 3.87e-01 | 0.0596 |
7748 | ZNF195 | LZE21T | Human | Esophagus | ESCC | 1.05e-02 | 1.85e-01 | 0.0655 |
7748 | ZNF195 | P1T-E | Human | Esophagus | ESCC | 4.31e-02 | 1.35e-01 | 0.0875 |
7748 | ZNF195 | P2T-E | Human | Esophagus | ESCC | 1.94e-26 | 5.52e-01 | 0.1177 |
7748 | ZNF195 | P4T-E | Human | Esophagus | ESCC | 2.74e-11 | 3.06e-01 | 0.1323 |
7748 | ZNF195 | P5T-E | Human | Esophagus | ESCC | 2.53e-06 | 5.12e-02 | 0.1327 |
7748 | ZNF195 | P8T-E | Human | Esophagus | ESCC | 2.31e-17 | 2.14e-01 | 0.0889 |
7748 | ZNF195 | P9T-E | Human | Esophagus | ESCC | 1.10e-06 | 1.33e-01 | 0.1131 |
7748 | ZNF195 | P10T-E | Human | Esophagus | ESCC | 4.66e-20 | 3.67e-01 | 0.116 |
7748 | ZNF195 | P11T-E | Human | Esophagus | ESCC | 1.00e-08 | 4.69e-01 | 0.1426 |
7748 | ZNF195 | P12T-E | Human | Esophagus | ESCC | 2.03e-22 | 3.95e-01 | 0.1122 |
7748 | ZNF195 | P15T-E | Human | Esophagus | ESCC | 2.04e-24 | 2.62e-01 | 0.1149 |
7748 | ZNF195 | P16T-E | Human | Esophagus | ESCC | 7.96e-08 | 1.70e-01 | 0.1153 |
7748 | ZNF195 | P17T-E | Human | Esophagus | ESCC | 6.23e-07 | 2.60e-01 | 0.1278 |
7748 | ZNF195 | P20T-E | Human | Esophagus | ESCC | 3.48e-17 | 2.61e-01 | 0.1124 |
7748 | ZNF195 | P21T-E | Human | Esophagus | ESCC | 1.96e-09 | 1.87e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF195 | SNV | Missense_Mutation | c.1389G>T | p.Glu463Asp | p.E463D | O14628 | protein_coding | deleterious(0.02) | benign(0.224) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ZNF195 | SNV | Missense_Mutation | rs779876785 | c.1744N>A | p.Glu582Lys | p.E582K | O14628 | protein_coding | deleterious(0.04) | benign(0.037) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF195 | SNV | Missense_Mutation | novel | c.1172T>A | p.Phe391Tyr | p.F391Y | O14628 | protein_coding | deleterious(0.04) | benign(0.139) | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD |
ZNF195 | SNV | Missense_Mutation | c.1793G>T | p.Arg598Ile | p.R598I | O14628 | protein_coding | tolerated(0.35) | probably_damaging(0.983) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF195 | SNV | Missense_Mutation | rs762257524 | c.1625G>T | p.Arg542Ile | p.R542I | O14628 | protein_coding | tolerated(0.38) | probably_damaging(0.983) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF195 | SNV | Missense_Mutation | c.70N>A | p.Ala24Thr | p.A24T | O14628 | protein_coding | deleterious(0.03) | possibly_damaging(0.798) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF195 | SNV | Missense_Mutation | novel | c.856N>A | p.His286Asn | p.H286N | O14628 | protein_coding | tolerated(0.71) | possibly_damaging(0.775) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF195 | SNV | Missense_Mutation | novel | c.1205N>T | p.Arg402Ile | p.R402I | O14628 | protein_coding | tolerated(0.44) | possibly_damaging(0.661) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF195 | SNV | Missense_Mutation | c.1793N>T | p.Arg598Ile | p.R598I | O14628 | protein_coding | tolerated(0.35) | probably_damaging(0.983) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF195 | SNV | Missense_Mutation | c.1289N>T | p.Arg430Ile | p.R430I | O14628 | protein_coding | tolerated(0.33) | probably_damaging(0.964) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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