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Gene: ZNF146 |
Gene summary for ZNF146 |
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Gene information | Species | Human | Gene symbol | ZNF146 | Gene ID | 7705 |
Gene name | zinc finger protein 146 | |
Gene Alias | OZF | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q15072 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7705 | ZNF146 | LZE4T | Human | Esophagus | ESCC | 3.24e-16 | 2.49e-01 | 0.0811 |
7705 | ZNF146 | LZE5T | Human | Esophagus | ESCC | 4.95e-03 | 3.87e-01 | 0.0514 |
7705 | ZNF146 | LZE7T | Human | Esophagus | ESCC | 2.91e-08 | 3.17e-01 | 0.0667 |
7705 | ZNF146 | LZE8T | Human | Esophagus | ESCC | 4.07e-09 | 1.92e-01 | 0.067 |
7705 | ZNF146 | LZE20T | Human | Esophagus | ESCC | 8.31e-07 | 7.68e-04 | 0.0662 |
7705 | ZNF146 | LZE22T | Human | Esophagus | ESCC | 1.09e-02 | 4.77e-02 | 0.068 |
7705 | ZNF146 | LZE24T | Human | Esophagus | ESCC | 4.50e-12 | 4.80e-01 | 0.0596 |
7705 | ZNF146 | LZE6T | Human | Esophagus | ESCC | 1.37e-08 | 2.76e-01 | 0.0845 |
7705 | ZNF146 | P1T-E | Human | Esophagus | ESCC | 9.37e-06 | 3.04e-01 | 0.0875 |
7705 | ZNF146 | P2T-E | Human | Esophagus | ESCC | 3.30e-23 | 4.28e-01 | 0.1177 |
7705 | ZNF146 | P4T-E | Human | Esophagus | ESCC | 1.18e-23 | 4.60e-01 | 0.1323 |
7705 | ZNF146 | P5T-E | Human | Esophagus | ESCC | 1.90e-17 | 1.74e-01 | 0.1327 |
7705 | ZNF146 | P8T-E | Human | Esophagus | ESCC | 1.45e-35 | 6.73e-01 | 0.0889 |
7705 | ZNF146 | P9T-E | Human | Esophagus | ESCC | 4.04e-11 | 2.94e-01 | 0.1131 |
7705 | ZNF146 | P10T-E | Human | Esophagus | ESCC | 3.38e-74 | 1.29e+00 | 0.116 |
7705 | ZNF146 | P11T-E | Human | Esophagus | ESCC | 8.85e-12 | 4.55e-01 | 0.1426 |
7705 | ZNF146 | P12T-E | Human | Esophagus | ESCC | 3.22e-29 | 6.49e-01 | 0.1122 |
7705 | ZNF146 | P15T-E | Human | Esophagus | ESCC | 5.72e-20 | 5.27e-01 | 0.1149 |
7705 | ZNF146 | P16T-E | Human | Esophagus | ESCC | 1.05e-20 | 3.90e-01 | 0.1153 |
7705 | ZNF146 | P17T-E | Human | Esophagus | ESCC | 2.94e-10 | 2.40e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF146 | SNV | Missense_Mutation | novel | c.779N>T | p.Arg260Ile | p.R260I | Q15072 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF146 | SNV | Missense_Mutation | novel | c.794N>G | p.Lys265Arg | p.K265R | Q15072 | protein_coding | deleterious(0) | benign(0.183) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF146 | SNV | Missense_Mutation | novel | c.535N>G | p.Thr179Ala | p.T179A | Q15072 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF146 | SNV | Missense_Mutation | c.679N>G | p.Leu227Val | p.L227V | Q15072 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-44-7660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Vaccine | recprame+as15 | PD | |
ZNF146 | SNV | Missense_Mutation | c.75N>G | p.Phe25Leu | p.F25L | Q15072 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF146 | SNV | Missense_Mutation | c.239N>T | p.Ser80Leu | p.S80L | Q15072 | protein_coding | deleterious(0) | benign(0.058) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF146 | SNV | Missense_Mutation | c.587G>T | p.Arg196Leu | p.R196L | Q15072 | protein_coding | tolerated(0.3) | benign(0.007) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD | |
ZNF146 | SNV | Missense_Mutation | c.116N>G | p.Thr39Arg | p.T39R | Q15072 | protein_coding | deleterious(0) | possibly_damaging(0.746) | TCGA-22-5480-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD | |
ZNF146 | SNV | Missense_Mutation | novel | c.34N>T | p.Gly12Trp | p.G12W | Q15072 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-37-A5EM-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF146 | SNV | Missense_Mutation | c.667N>G | p.Gln223Glu | p.Q223E | Q15072 | protein_coding | tolerated(0.05) | possibly_damaging(0.875) | TCGA-94-7943-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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