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Gene: ZNF134 |
Gene summary for ZNF134 |
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Gene information | Species | Human | Gene symbol | ZNF134 | Gene ID | 7693 |
Gene name | zinc finger protein 134 | |
Gene Alias | pHZ-15 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P52741 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7693 | ZNF134 | LZE24T | Human | Esophagus | ESCC | 1.60e-03 | 9.37e-02 | 0.0596 |
7693 | ZNF134 | P2T-E | Human | Esophagus | ESCC | 2.50e-10 | 1.84e-01 | 0.1177 |
7693 | ZNF134 | P8T-E | Human | Esophagus | ESCC | 3.22e-22 | 3.87e-01 | 0.0889 |
7693 | ZNF134 | P10T-E | Human | Esophagus | ESCC | 8.30e-28 | 5.44e-01 | 0.116 |
7693 | ZNF134 | P11T-E | Human | Esophagus | ESCC | 4.81e-07 | 3.35e-01 | 0.1426 |
7693 | ZNF134 | P12T-E | Human | Esophagus | ESCC | 2.18e-13 | 2.42e-01 | 0.1122 |
7693 | ZNF134 | P16T-E | Human | Esophagus | ESCC | 2.38e-12 | 2.03e-01 | 0.1153 |
7693 | ZNF134 | P21T-E | Human | Esophagus | ESCC | 5.70e-04 | 4.52e-02 | 0.1617 |
7693 | ZNF134 | P22T-E | Human | Esophagus | ESCC | 2.84e-12 | 2.30e-01 | 0.1236 |
7693 | ZNF134 | P24T-E | Human | Esophagus | ESCC | 6.48e-03 | 5.12e-02 | 0.1287 |
7693 | ZNF134 | P27T-E | Human | Esophagus | ESCC | 2.48e-30 | 1.83e-01 | 0.1055 |
7693 | ZNF134 | P28T-E | Human | Esophagus | ESCC | 6.58e-08 | 7.29e-02 | 0.1149 |
7693 | ZNF134 | P30T-E | Human | Esophagus | ESCC | 4.10e-09 | 3.16e-01 | 0.137 |
7693 | ZNF134 | P32T-E | Human | Esophagus | ESCC | 2.17e-06 | 1.42e-01 | 0.1666 |
7693 | ZNF134 | P36T-E | Human | Esophagus | ESCC | 3.88e-04 | 1.61e-01 | 0.1187 |
7693 | ZNF134 | P40T-E | Human | Esophagus | ESCC | 9.46e-03 | 7.23e-02 | 0.109 |
7693 | ZNF134 | P42T-E | Human | Esophagus | ESCC | 3.89e-05 | 1.08e-01 | 0.1175 |
7693 | ZNF134 | P47T-E | Human | Esophagus | ESCC | 9.91e-08 | 9.29e-02 | 0.1067 |
7693 | ZNF134 | P48T-E | Human | Esophagus | ESCC | 3.47e-07 | 9.41e-02 | 0.0959 |
7693 | ZNF134 | P52T-E | Human | Esophagus | ESCC | 7.65e-15 | 1.86e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF134 | SNV | Missense_Mutation | novel | c.496G>T | p.Gly166Trp | p.G166W | P52741 | protein_coding | deleterious(0.01) | probably_damaging(0.919) | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF134 | SNV | Missense_Mutation | c.688N>T | p.Arg230Trp | p.R230W | P52741 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF134 | SNV | Missense_Mutation | c.1257G>C | p.Gln419His | p.Q419H | P52741 | protein_coding | tolerated(0.12) | possibly_damaging(0.601) | TCGA-50-5946-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF134 | SNV | Missense_Mutation | novel | c.545N>T | p.Gly182Val | p.G182V | P52741 | protein_coding | deleterious(0.03) | probably_damaging(0.988) | TCGA-62-A46U-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
ZNF134 | SNV | Missense_Mutation | novel | c.857N>T | p.Arg286Met | p.R286M | P52741 | protein_coding | deleterious(0.01) | possibly_damaging(0.894) | TCGA-56-A4ZK-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF134 | SNV | Missense_Mutation | novel | c.1187G>A | p.Gly396Glu | p.G396E | P52741 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF134 | SNV | Missense_Mutation | novel | c.911N>A | p.Val304Asp | p.V304D | P52741 | protein_coding | deleterious(0) | benign(0.178) | TCGA-CN-5373-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF134 | SNV | Missense_Mutation | c.1091N>T | p.Arg364Met | p.R364M | P52741 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-CV-6956-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF134 | SNV | Missense_Mutation | novel | c.462N>A | p.His154Gln | p.H154Q | P52741 | protein_coding | tolerated(0.13) | benign(0) | TCGA-MZ-A7D7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF134 | SNV | Missense_Mutation | c.937N>A | p.Glu313Lys | p.E313K | P52741 | protein_coding | deleterious(0.01) | probably_damaging(0.915) | TCGA-HC-A631-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7693 | ZNF134 | NA | methylphenidate | METHYLPHENIDATE | 29382897 |
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