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Gene: ZNF121 |
Gene summary for ZNF121 |
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Gene information | Species | Human | Gene symbol | ZNF121 | Gene ID | 7675 |
Gene name | zinc finger protein 121 | |
Gene Alias | D19S204 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P58317 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7675 | ZNF121 | LZE4T | Human | Esophagus | ESCC | 5.37e-03 | 1.72e-01 | 0.0811 |
7675 | ZNF121 | LZE5T | Human | Esophagus | ESCC | 2.66e-03 | 4.39e-01 | 0.0514 |
7675 | ZNF121 | LZE7T | Human | Esophagus | ESCC | 1.30e-07 | 4.74e-01 | 0.0667 |
7675 | ZNF121 | LZE8T | Human | Esophagus | ESCC | 1.29e-10 | 1.61e-01 | 0.067 |
7675 | ZNF121 | LZE20T | Human | Esophagus | ESCC | 4.75e-05 | -3.80e-03 | 0.0662 |
7675 | ZNF121 | LZE24T | Human | Esophagus | ESCC | 8.57e-15 | 1.84e-01 | 0.0596 |
7675 | ZNF121 | LZE21T | Human | Esophagus | ESCC | 1.80e-03 | 1.54e-01 | 0.0655 |
7675 | ZNF121 | P1T-E | Human | Esophagus | ESCC | 1.26e-06 | 2.86e-01 | 0.0875 |
7675 | ZNF121 | P2T-E | Human | Esophagus | ESCC | 2.93e-15 | 7.81e-03 | 0.1177 |
7675 | ZNF121 | P4T-E | Human | Esophagus | ESCC | 3.27e-13 | 1.58e-01 | 0.1323 |
7675 | ZNF121 | P5T-E | Human | Esophagus | ESCC | 1.08e-11 | 1.36e-01 | 0.1327 |
7675 | ZNF121 | P8T-E | Human | Esophagus | ESCC | 1.69e-24 | 2.95e-01 | 0.0889 |
7675 | ZNF121 | P9T-E | Human | Esophagus | ESCC | 1.91e-06 | 1.20e-01 | 0.1131 |
7675 | ZNF121 | P10T-E | Human | Esophagus | ESCC | 3.38e-19 | 2.94e-01 | 0.116 |
7675 | ZNF121 | P11T-E | Human | Esophagus | ESCC | 1.21e-05 | 1.62e-01 | 0.1426 |
7675 | ZNF121 | P12T-E | Human | Esophagus | ESCC | 1.90e-13 | 1.93e-01 | 0.1122 |
7675 | ZNF121 | P15T-E | Human | Esophagus | ESCC | 6.21e-12 | 5.72e-02 | 0.1149 |
7675 | ZNF121 | P16T-E | Human | Esophagus | ESCC | 1.16e-12 | 4.61e-02 | 0.1153 |
7675 | ZNF121 | P17T-E | Human | Esophagus | ESCC | 9.45e-09 | 2.55e-01 | 0.1278 |
7675 | ZNF121 | P20T-E | Human | Esophagus | ESCC | 2.41e-12 | 1.10e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF121 | SNV | Missense_Mutation | rs144655023 | c.361N>C | p.Cys121Arg | p.C121R | P58317 | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-FV-A3I0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD |
ZNF121 | SNV | Missense_Mutation | c.239G>T | p.Arg80Ile | p.R80I | P58317 | protein_coding | deleterious(0.01) | possibly_damaging(0.825) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF121 | SNV | Missense_Mutation | novel | c.803C>T | p.Ser268Phe | p.S268F | P58317 | protein_coding | deleterious(0.04) | benign(0.278) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | c.385N>T | p.Thr129Ser | p.T129S | P58317 | protein_coding | tolerated(0.2) | benign(0.07) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | |
ZNF121 | SNV | Missense_Mutation | novel | c.916N>A | p.His306Asn | p.H306N | P58317 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-46-3766-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | c.413N>C | p.His138Pro | p.H138P | P58317 | protein_coding | tolerated(0.16) | possibly_damaging(0.543) | TCGA-66-2756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF121 | SNV | Missense_Mutation | novel | c.641G>T | p.Gly214Val | p.G214V | P58317 | protein_coding | tolerated(0.46) | benign(0.316) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | c.1079N>T | p.Arg360Ile | p.R360I | P58317 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-77-8145-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF121 | SNV | Missense_Mutation | novel | c.635G>T | p.Arg212Leu | p.R212L | P58317 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-CV-A45W-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | c.1045N>G | p.Phe349Val | p.F349V | P58317 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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