TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZFP30 | CHO | Liver | HCC | RASSF6,SLC33A1,PIP4K2A, etc. | 4.44e-16 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_HCC/regulons_activity_in_dotplot.png) |
ZFP30 | CD8TEREX | Thyroid | ADJ | COL1A2,COL3A1,YJEFN3, etc. | 8.30e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZFP30 | NKT | Thyroid | ADJ | COL1A2,COL3A1,YJEFN3, etc. | 5.26e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZFP30 | NKT | Thyroid | ATC | COL1A2,COL3A1,YJEFN3, etc. | 2.44e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ATC/regulons_activity_in_dotplot.png) |
ZFP30 | M1MAC | Thyroid | goiters | COL1A2,COL3A1,YJEFN3, etc. | 9.86e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_goiters/regulons_activity_in_dotplot.png) |
ZFP30 | GDT | Thyroid | Healthy | COL1A2,COL3A1,YJEFN3, etc. | 9.72e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP30 | TH2 | Thyroid | Healthy | COL1A2,COL3A1,YJEFN3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP30 | GC | Thyroid | Healthy | COL1A2,COL3A1,YJEFN3, etc. | 1.52e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP30 | pDC | Thyroid | HT | COL1A2,COL3A1,YJEFN3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_HT/regulons_activity_in_dotplot.png) |
ZFP30 | TFH | Thyroid | HT | COL1A2,COL3A1,YJEFN3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_HT/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFP30 | SNV | Missense_Mutation | rs752442394 | c.475G>A | p.Glu159Lys | p.E159K | Q9Y2G7 | protein_coding | tolerated(0.23) | benign(0.031) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP30 | SNV | Missense_Mutation | | c.323G>T | p.Arg108Ile | p.R108I | Q9Y2G7 | protein_coding | tolerated(0.35) | benign(0.278) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP30 | SNV | Missense_Mutation | | c.1121N>T | p.Arg374Ile | p.R374I | Q9Y2G7 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP30 | SNV | Missense_Mutation | rs752442394 | c.475G>A | p.Glu159Lys | p.E159K | Q9Y2G7 | protein_coding | tolerated(0.23) | benign(0.031) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP30 | SNV | Missense_Mutation | rs767270636 | c.941G>A | p.Arg314Gln | p.R314Q | Q9Y2G7 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZFP30 | SNV | Missense_Mutation | novel | c.7C>A | p.Arg3Ser | p.R3S | Q9Y2G7 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP30 | SNV | Missense_Mutation | novel | c.1040N>A | p.Ile347Asn | p.I347N | Q9Y2G7 | protein_coding | deleterious(0) | possibly_damaging(0.835) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZFP30 | SNV | Missense_Mutation | | c.323N>T | p.Arg108Ile | p.R108I | Q9Y2G7 | protein_coding | tolerated(0.35) | benign(0.278) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZFP30 | SNV | Missense_Mutation | rs777324427 | c.1457N>A | p.Arg486Lys | p.R486K | Q9Y2G7 | protein_coding | tolerated(0.22) | benign(0.054) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ZFP30 | SNV | Missense_Mutation | | c.323N>T | p.Arg108Ile | p.R108I | Q9Y2G7 | protein_coding | tolerated(0.35) | benign(0.278) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |