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Gene: WSB1 |
Gene summary for WSB1 |
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Gene information | Species | Human | Gene symbol | WSB1 | Gene ID | 26118 |
Gene name | WD repeat and SOCS box containing 1 | |
Gene Alias | SWIP1 | |
Cytomap | 17q11.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NC76 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26118 | WSB1 | GSM4909282 | Human | Breast | IDC | 8.15e-06 | -4.28e-01 | -0.0288 |
26118 | WSB1 | GSM4909285 | Human | Breast | IDC | 1.64e-04 | -3.59e-01 | 0.21 |
26118 | WSB1 | GSM4909286 | Human | Breast | IDC | 1.77e-04 | -1.82e-01 | 0.1081 |
26118 | WSB1 | GSM4909287 | Human | Breast | IDC | 1.73e-03 | -3.65e-01 | 0.2057 |
26118 | WSB1 | GSM4909290 | Human | Breast | IDC | 7.85e-06 | -4.47e-01 | 0.2096 |
26118 | WSB1 | GSM4909294 | Human | Breast | IDC | 1.09e-02 | -1.98e-01 | 0.2022 |
26118 | WSB1 | GSM4909296 | Human | Breast | IDC | 2.47e-19 | -5.32e-01 | 0.1524 |
26118 | WSB1 | GSM4909297 | Human | Breast | IDC | 7.89e-12 | -1.89e-01 | 0.1517 |
26118 | WSB1 | GSM4909302 | Human | Breast | IDC | 1.15e-03 | -2.97e-01 | 0.1545 |
26118 | WSB1 | GSM4909304 | Human | Breast | IDC | 1.02e-05 | -3.78e-01 | 0.1636 |
26118 | WSB1 | GSM4909306 | Human | Breast | IDC | 1.20e-07 | -3.71e-01 | 0.1564 |
26118 | WSB1 | GSM4909307 | Human | Breast | IDC | 1.27e-03 | -3.49e-01 | 0.1569 |
26118 | WSB1 | GSM4909308 | Human | Breast | IDC | 4.93e-03 | -3.17e-01 | 0.158 |
26118 | WSB1 | GSM4909311 | Human | Breast | IDC | 5.73e-38 | -6.55e-01 | 0.1534 |
26118 | WSB1 | GSM4909312 | Human | Breast | IDC | 2.98e-14 | -4.85e-01 | 0.1552 |
26118 | WSB1 | GSM4909316 | Human | Breast | IDC | 4.84e-04 | -5.50e-01 | 0.21 |
26118 | WSB1 | GSM4909319 | Human | Breast | IDC | 1.72e-34 | -5.36e-01 | 0.1563 |
26118 | WSB1 | GSM4909320 | Human | Breast | IDC | 8.48e-06 | -5.38e-01 | 0.1575 |
26118 | WSB1 | GSM4909321 | Human | Breast | IDC | 2.25e-13 | -2.13e-01 | 0.1559 |
26118 | WSB1 | ctrl6 | Human | Breast | Precancer | 9.34e-12 | 6.32e-01 | -0.0061 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WSB1 | SNV | Missense_Mutation | novel | c.749N>T | p.Arg250Leu | p.R250L | Q9Y6I7 | protein_coding | deleterious(0.04) | possibly_damaging(0.722) | TCGA-50-6673-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WSB1 | SNV | Missense_Mutation | rs144114473 | c.211N>G | p.Leu71Val | p.L71V | Q9Y6I7 | protein_coding | tolerated(0.93) | benign(0.027) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
WSB1 | SNV | Missense_Mutation | novel | c.559N>C | p.Val187Leu | p.V187L | Q9Y6I7 | protein_coding | tolerated(0.06) | benign(0.389) | TCGA-22-5483-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD |
WSB1 | SNV | Missense_Mutation | novel | c.593G>T | p.Trp198Leu | p.W198L | Q9Y6I7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WSB1 | SNV | Missense_Mutation | novel | c.161N>T | p.Gly54Val | p.G54V | Q9Y6I7 | protein_coding | deleterious(0) | benign(0.039) | TCGA-CV-7095-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WSB1 | SNV | Missense_Mutation | rs774835815 | c.13N>T | p.Pro5Ser | p.P5S | Q9Y6I7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.992) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WSB1 | insertion | Frame_Shift_Ins | novel | c.711_711+1insAA | p.Val238LysfsTer12 | p.V238Kfs*12 | Q9Y6I7 | protein_coding | TCGA-CV-A45U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
WSB1 | SNV | Missense_Mutation | rs774909949 | c.836G>A | p.Arg279Gln | p.R279Q | Q9Y6I7 | protein_coding | tolerated(0.37) | probably_damaging(0.998) | TCGA-3M-AB46-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | CR |
WSB1 | SNV | Missense_Mutation | c.1232N>T | p.Ser411Phe | p.S411F | Q9Y6I7 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WSB1 | SNV | Missense_Mutation | c.152G>C | p.Trp51Ser | p.W51S | Q9Y6I7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BR-A4PF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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