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Gene: WRNIP1 |
Gene summary for WRNIP1 |
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Gene information | Species | Human | Gene symbol | WRNIP1 | Gene ID | 56897 |
Gene name | WRN helicase interacting protein 1 | |
Gene Alias | CFAP93 | |
Cytomap | 6p25.2 | |
Gene Type | protein-coding | GO ID | GO:0000731 | UniProtAcc | Q96S55 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56897 | WRNIP1 | LZE2T | Human | Esophagus | ESCC | 3.40e-02 | 2.16e-01 | 0.082 |
56897 | WRNIP1 | LZE7T | Human | Esophagus | ESCC | 9.51e-05 | 8.50e-02 | 0.0667 |
56897 | WRNIP1 | LZE24T | Human | Esophagus | ESCC | 7.02e-06 | 9.95e-02 | 0.0596 |
56897 | WRNIP1 | P2T-E | Human | Esophagus | ESCC | 1.40e-21 | 3.39e-01 | 0.1177 |
56897 | WRNIP1 | P4T-E | Human | Esophagus | ESCC | 4.26e-10 | 2.17e-01 | 0.1323 |
56897 | WRNIP1 | P5T-E | Human | Esophagus | ESCC | 9.81e-13 | 1.03e-01 | 0.1327 |
56897 | WRNIP1 | P8T-E | Human | Esophagus | ESCC | 5.48e-15 | 6.91e-02 | 0.0889 |
56897 | WRNIP1 | P9T-E | Human | Esophagus | ESCC | 2.82e-08 | 1.80e-01 | 0.1131 |
56897 | WRNIP1 | P10T-E | Human | Esophagus | ESCC | 2.45e-10 | 8.44e-02 | 0.116 |
56897 | WRNIP1 | P11T-E | Human | Esophagus | ESCC | 1.81e-06 | 2.56e-01 | 0.1426 |
56897 | WRNIP1 | P12T-E | Human | Esophagus | ESCC | 2.56e-09 | 1.83e-02 | 0.1122 |
56897 | WRNIP1 | P15T-E | Human | Esophagus | ESCC | 6.52e-09 | 7.88e-02 | 0.1149 |
56897 | WRNIP1 | P16T-E | Human | Esophagus | ESCC | 2.95e-08 | 4.32e-02 | 0.1153 |
56897 | WRNIP1 | P17T-E | Human | Esophagus | ESCC | 2.34e-05 | 1.98e-01 | 0.1278 |
56897 | WRNIP1 | P20T-E | Human | Esophagus | ESCC | 7.75e-12 | 5.59e-02 | 0.1124 |
56897 | WRNIP1 | P21T-E | Human | Esophagus | ESCC | 1.05e-14 | 1.21e-01 | 0.1617 |
56897 | WRNIP1 | P22T-E | Human | Esophagus | ESCC | 3.05e-15 | 1.90e-02 | 0.1236 |
56897 | WRNIP1 | P23T-E | Human | Esophagus | ESCC | 9.81e-14 | 2.85e-01 | 0.108 |
56897 | WRNIP1 | P26T-E | Human | Esophagus | ESCC | 3.11e-17 | 1.30e-01 | 0.1276 |
56897 | WRNIP1 | P27T-E | Human | Esophagus | ESCC | 2.20e-13 | 1.23e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:003239214 | Esophagus | ESCC | DNA geometric change | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:003250813 | Esophagus | ESCC | DNA duplex unwinding | 58/8552 | 84/18723 | 1.23e-05 | 1.14e-04 | 58 |
GO:00062826 | Esophagus | ESCC | regulation of DNA repair | 82/8552 | 130/18723 | 4.65e-05 | 3.66e-04 | 82 |
GO:00062701 | Esophagus | ESCC | DNA replication initiation | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:0090329 | Esophagus | ESCC | regulation of DNA-dependent DNA replication | 30/8552 | 46/18723 | 5.91e-03 | 2.18e-02 | 30 |
GO:005105221 | Liver | HCC | regulation of DNA metabolic process | 198/7958 | 359/18723 | 7.62e-07 | 1.17e-05 | 198 |
GO:200102021 | Liver | HCC | regulation of response to DNA damage stimulus | 128/7958 | 219/18723 | 1.31e-06 | 1.90e-05 | 128 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00718975 | Liver | HCC | DNA biosynthetic process | 99/7958 | 180/18723 | 4.66e-04 | 3.08e-03 | 99 |
GO:003239211 | Liver | HCC | DNA geometric change | 54/7958 | 90/18723 | 6.04e-04 | 3.79e-03 | 54 |
GO:00062824 | Liver | HCC | regulation of DNA repair | 74/7958 | 130/18723 | 6.27e-04 | 3.89e-03 | 74 |
GO:00325081 | Liver | HCC | DNA duplex unwinding | 49/7958 | 84/18723 | 2.46e-03 | 1.19e-02 | 49 |
GO:00062751 | Liver | HCC | regulation of DNA replication | 60/7958 | 107/18723 | 3.15e-03 | 1.46e-02 | 60 |
GO:0006261 | Liver | HCC | DNA-dependent DNA replication | 80/7958 | 151/18723 | 5.91e-03 | 2.44e-02 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WRNIP1 | SNV | Missense_Mutation | novel | c.1213C>A | p.Arg405Ser | p.R405S | Q96S55 | protein_coding | tolerated(0.15) | benign(0.011) | TCGA-55-5899-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
WRNIP1 | SNV | Missense_Mutation | rs373929786 | c.917N>A | p.Arg306Gln | p.R306Q | Q96S55 | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WRNIP1 | deletion | Frame_Shift_Del | c.96delC | p.Asn33ThrfsTer48 | p.N33Tfs*48 | Q96S55 | protein_coding | TCGA-55-8514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
WRNIP1 | SNV | Missense_Mutation | novel | c.1724T>G | p.Val575Gly | p.V575G | Q96S55 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-CV-5436-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WRNIP1 | SNV | Missense_Mutation | novel | c.1297N>A | p.Ala433Thr | p.A433T | Q96S55 | protein_coding | deleterious(0.01) | possibly_damaging(0.54) | TCGA-CV-6953-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
WRNIP1 | SNV | Missense_Mutation | c.1492G>A | p.Glu498Lys | p.E498K | Q96S55 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
WRNIP1 | SNV | Missense_Mutation | novel | c.1738T>C | p.Cys580Arg | p.C580R | Q96S55 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WRNIP1 | deletion | Frame_Shift_Del | novel | c.1839delC | p.Val614CysfsTer5 | p.V614Cfs*5 | Q96S55 | protein_coding | TCGA-CD-A4MJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | ||
WRNIP1 | insertion | Frame_Shift_Ins | novel | c.1592_1593insC | p.Leu533ThrfsTer40 | p.L533Tfs*40 | Q96S55 | protein_coding | TCGA-CG-5725-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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