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Gene: WDR6 |
Gene summary for WDR6 |
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Gene information | Species | Human | Gene symbol | WDR6 | Gene ID | 11180 |
Gene name | WD repeat domain 6 | |
Gene Alias | WDR6 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q9H9M3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11180 | WDR6 | S43 | Human | Liver | Cirrhotic | 2.42e-07 | -1.48e-01 | -0.0187 |
11180 | WDR6 | HCC1_Meng | Human | Liver | HCC | 1.17e-66 | 8.50e-02 | 0.0246 |
11180 | WDR6 | HCC2_Meng | Human | Liver | HCC | 3.01e-08 | -8.89e-02 | 0.0107 |
11180 | WDR6 | cirrhotic2 | Human | Liver | Cirrhotic | 2.28e-07 | 2.12e-01 | 0.0201 |
11180 | WDR6 | cirrhotic3 | Human | Liver | Cirrhotic | 4.15e-02 | 7.09e-02 | 0.0215 |
11180 | WDR6 | HCC1 | Human | Liver | HCC | 2.12e-14 | 4.52e+00 | 0.5336 |
11180 | WDR6 | HCC2 | Human | Liver | HCC | 1.11e-17 | 4.27e+00 | 0.5341 |
11180 | WDR6 | S014 | Human | Liver | HCC | 8.87e-17 | 8.54e-01 | 0.2254 |
11180 | WDR6 | S015 | Human | Liver | HCC | 7.51e-15 | 8.66e-01 | 0.2375 |
11180 | WDR6 | S016 | Human | Liver | HCC | 5.55e-20 | 8.39e-01 | 0.2243 |
11180 | WDR6 | S027 | Human | Liver | HCC | 1.43e-08 | 9.78e-01 | 0.2446 |
11180 | WDR6 | S028 | Human | Liver | HCC | 5.79e-27 | 1.22e+00 | 0.2503 |
11180 | WDR6 | S029 | Human | Liver | HCC | 6.70e-24 | 1.15e+00 | 0.2581 |
11180 | WDR6 | C04 | Human | Oral cavity | OSCC | 1.57e-05 | 3.67e-01 | 0.2633 |
11180 | WDR6 | C21 | Human | Oral cavity | OSCC | 3.41e-15 | 5.25e-01 | 0.2678 |
11180 | WDR6 | C30 | Human | Oral cavity | OSCC | 9.46e-18 | 8.51e-01 | 0.3055 |
11180 | WDR6 | C38 | Human | Oral cavity | OSCC | 6.74e-04 | 4.37e-01 | 0.172 |
11180 | WDR6 | C43 | Human | Oral cavity | OSCC | 1.64e-11 | 1.74e-01 | 0.1704 |
11180 | WDR6 | C46 | Human | Oral cavity | OSCC | 1.58e-20 | 5.38e-01 | 0.1673 |
11180 | WDR6 | C51 | Human | Oral cavity | OSCC | 2.23e-03 | 4.19e-01 | 0.2674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:000636814 | Esophagus | ESCC | transcription elongation from RNA polymerase II promoter | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:00310583 | Esophagus | ESCC | positive regulation of histone modification | 65/8552 | 92/18723 | 1.04e-06 | 1.31e-05 | 65 |
GO:00165718 | Esophagus | ESCC | histone methylation | 89/8552 | 141/18723 | 2.17e-05 | 1.87e-04 | 89 |
GO:003496814 | Esophagus | ESCC | histone lysine methylation | 72/8552 | 115/18723 | 1.85e-04 | 1.18e-03 | 72 |
GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
GO:003106013 | Esophagus | ESCC | regulation of histone methylation | 46/8552 | 69/18723 | 3.46e-04 | 2.03e-03 | 46 |
GO:001802214 | Esophagus | ESCC | peptidyl-lysine methylation | 79/8552 | 131/18723 | 5.17e-04 | 2.86e-03 | 79 |
GO:0045637111 | Esophagus | ESCC | regulation of myeloid cell differentiation | 118/8552 | 210/18723 | 1.35e-03 | 6.43e-03 | 118 |
GO:003106211 | Esophagus | ESCC | positive regulation of histone methylation | 28/8552 | 41/18723 | 2.88e-03 | 1.21e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR6 | insertion | Frame_Shift_Ins | rs750038548 | c.2504_2505insG | p.Arg838AlafsTer3 | p.R838Afs*3 | protein_coding | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
WDR6 | insertion | Frame_Shift_Ins | rs754270593 | c.3001_3002insC | p.Ser1003LeufsTer21 | p.S1003Lfs*21 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
WDR6 | deletion | Frame_Shift_Del | novel | c.1549delN | p.Pro518GlnfsTer55 | p.P518Qfs*55 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
WDR6 | deletion | Frame_Shift_Del | c.2505delN | p.Arg838GlyfsTer33 | p.R838Gfs*33 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||||
WDR6 | deletion | Frame_Shift_Del | c.2505delN | p.Arg838GlyfsTer33 | p.R838Gfs*33 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||||
WDR6 | SNV | Missense_Mutation | novel | c.2776N>G | p.Ser926Ala | p.S926A | protein_coding | tolerated(0.68) | benign(0.028) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WDR6 | SNV | Missense_Mutation | c.1618G>A | p.Asp540Asn | p.D540N | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
WDR6 | SNV | Missense_Mutation | novel | c.487C>A | p.Leu163Met | p.L163M | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AJ-A8CV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR6 | SNV | Missense_Mutation | rs780448380 | c.1949G>A | p.Arg650His | p.R650H | protein_coding | tolerated(0.57) | benign(0.007) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR6 | SNV | Missense_Mutation | c.1078N>T | p.Arg360Cys | p.R360C | protein_coding | deleterious(0.05) | benign(0.019) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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