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Gene: WDR53 |
Gene summary for WDR53 |
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Gene information | Species | Human | Gene symbol | WDR53 | Gene ID | 348793 |
Gene name | WD repeat domain 53 | |
Gene Alias | WDR53 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q7Z5U6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
348793 | WDR53 | LZE4T | Human | Esophagus | ESCC | 8.65e-04 | 1.50e-01 | 0.0811 |
348793 | WDR53 | LZE24T | Human | Esophagus | ESCC | 1.09e-12 | 1.49e-01 | 0.0596 |
348793 | WDR53 | LZE6T | Human | Esophagus | ESCC | 1.92e-02 | 2.13e-01 | 0.0845 |
348793 | WDR53 | P2T-E | Human | Esophagus | ESCC | 3.67e-18 | 3.33e-01 | 0.1177 |
348793 | WDR53 | P4T-E | Human | Esophagus | ESCC | 4.61e-12 | 3.47e-01 | 0.1323 |
348793 | WDR53 | P5T-E | Human | Esophagus | ESCC | 4.71e-16 | 1.90e-01 | 0.1327 |
348793 | WDR53 | P8T-E | Human | Esophagus | ESCC | 5.71e-07 | 1.09e-01 | 0.0889 |
348793 | WDR53 | P9T-E | Human | Esophagus | ESCC | 2.18e-05 | 1.93e-01 | 0.1131 |
348793 | WDR53 | P10T-E | Human | Esophagus | ESCC | 4.50e-11 | 2.06e-01 | 0.116 |
348793 | WDR53 | P11T-E | Human | Esophagus | ESCC | 1.24e-10 | 3.54e-01 | 0.1426 |
348793 | WDR53 | P12T-E | Human | Esophagus | ESCC | 1.94e-08 | 1.42e-01 | 0.1122 |
348793 | WDR53 | P15T-E | Human | Esophagus | ESCC | 5.25e-15 | 2.88e-01 | 0.1149 |
348793 | WDR53 | P16T-E | Human | Esophagus | ESCC | 1.67e-10 | 1.59e-01 | 0.1153 |
348793 | WDR53 | P20T-E | Human | Esophagus | ESCC | 5.29e-05 | 1.30e-01 | 0.1124 |
348793 | WDR53 | P21T-E | Human | Esophagus | ESCC | 5.69e-06 | 1.29e-01 | 0.1617 |
348793 | WDR53 | P22T-E | Human | Esophagus | ESCC | 4.64e-15 | 2.31e-01 | 0.1236 |
348793 | WDR53 | P23T-E | Human | Esophagus | ESCC | 4.49e-14 | 3.27e-01 | 0.108 |
348793 | WDR53 | P24T-E | Human | Esophagus | ESCC | 1.49e-06 | 1.44e-01 | 0.1287 |
348793 | WDR53 | P26T-E | Human | Esophagus | ESCC | 9.65e-16 | 2.37e-01 | 0.1276 |
348793 | WDR53 | P27T-E | Human | Esophagus | ESCC | 1.63e-07 | 2.08e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR53 | SNV | Missense_Mutation | c.995G>T | p.Gly332Val | p.G332V | Q7Z5U6 | protein_coding | tolerated(0.5) | benign(0.034) | TCGA-99-8028-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR53 | SNV | Missense_Mutation | novel | c.145N>G | p.Gln49Glu | p.Q49E | Q7Z5U6 | protein_coding | tolerated(0.5) | benign(0) | TCGA-34-7107-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR53 | SNV | Missense_Mutation | novel | c.959N>C | p.Asn320Thr | p.N320T | Q7Z5U6 | protein_coding | tolerated(0.58) | benign(0) | TCGA-85-7697-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR53 | SNV | Missense_Mutation | rs778792411 | c.739G>C | p.Val247Leu | p.V247L | Q7Z5U6 | protein_coding | tolerated(0.05) | possibly_damaging(0.856) | TCGA-85-A50M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WDR53 | SNV | Missense_Mutation | novel | c.472G>T | p.Asp158Tyr | p.D158Y | Q7Z5U6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-94-A4VJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR53 | SNV | Missense_Mutation | novel | c.791N>G | p.Lys264Arg | p.K264R | Q7Z5U6 | protein_coding | tolerated(0.21) | benign(0.018) | TCGA-CN-4728-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vectibix | SD |
WDR53 | SNV | Missense_Mutation | novel | c.553A>G | p.Met185Val | p.M185V | Q7Z5U6 | protein_coding | tolerated(0.34) | benign(0) | TCGA-CV-6933-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
WDR53 | deletion | Frame_Shift_Del | novel | c.1074_1075delTT | p.Phe358LeufsTer? | p.F358Lfs*? | Q7Z5U6 | protein_coding | TCGA-QK-A8Z7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | ||
WDR53 | SNV | Missense_Mutation | c.770T>G | p.Leu257Arg | p.L257R | Q7Z5U6 | protein_coding | deleterious(0) | possibly_damaging(0.776) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
WDR53 | SNV | Missense_Mutation | c.35C>A | p.Pro12His | p.P12H | Q7Z5U6 | protein_coding | deleterious(0.01) | benign(0.417) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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