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Gene: VTA1 |
Gene summary for VTA1 |
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Gene information | Species | Human | Gene symbol | VTA1 | Gene ID | 51534 |
Gene name | vesicle trafficking 1 | |
Gene Alias | 6orf55 | |
Cytomap | 6q24.1-q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A087WY55 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51534 | VTA1 | LZE4T | Human | Esophagus | ESCC | 9.76e-22 | 4.23e-01 | 0.0811 |
51534 | VTA1 | LZE5T | Human | Esophagus | ESCC | 2.01e-03 | 3.59e-01 | 0.0514 |
51534 | VTA1 | LZE7T | Human | Esophagus | ESCC | 1.70e-06 | 4.33e-01 | 0.0667 |
51534 | VTA1 | LZE8T | Human | Esophagus | ESCC | 9.89e-07 | 1.24e-01 | 0.067 |
51534 | VTA1 | LZE20T | Human | Esophagus | ESCC | 1.15e-05 | 1.91e-01 | 0.0662 |
51534 | VTA1 | LZE22T | Human | Esophagus | ESCC | 6.24e-03 | 1.49e-01 | 0.068 |
51534 | VTA1 | LZE24T | Human | Esophagus | ESCC | 2.58e-15 | 4.25e-01 | 0.0596 |
51534 | VTA1 | LZE6T | Human | Esophagus | ESCC | 3.42e-04 | 3.73e-01 | 0.0845 |
51534 | VTA1 | P2T-E | Human | Esophagus | ESCC | 5.50e-31 | 5.30e-01 | 0.1177 |
51534 | VTA1 | P4T-E | Human | Esophagus | ESCC | 3.84e-26 | 6.55e-01 | 0.1323 |
51534 | VTA1 | P5T-E | Human | Esophagus | ESCC | 1.18e-27 | 6.59e-01 | 0.1327 |
51534 | VTA1 | P8T-E | Human | Esophagus | ESCC | 1.09e-30 | 5.38e-01 | 0.0889 |
51534 | VTA1 | P9T-E | Human | Esophagus | ESCC | 3.87e-11 | 2.65e-01 | 0.1131 |
51534 | VTA1 | P10T-E | Human | Esophagus | ESCC | 4.41e-33 | 5.25e-01 | 0.116 |
51534 | VTA1 | P11T-E | Human | Esophagus | ESCC | 1.20e-17 | 7.06e-01 | 0.1426 |
51534 | VTA1 | P12T-E | Human | Esophagus | ESCC | 4.61e-28 | 4.62e-01 | 0.1122 |
51534 | VTA1 | P15T-E | Human | Esophagus | ESCC | 7.59e-40 | 7.63e-01 | 0.1149 |
51534 | VTA1 | P16T-E | Human | Esophagus | ESCC | 2.01e-44 | 7.63e-01 | 0.1153 |
51534 | VTA1 | P17T-E | Human | Esophagus | ESCC | 6.10e-13 | 4.66e-01 | 0.1278 |
51534 | VTA1 | P19T-E | Human | Esophagus | ESCC | 2.58e-11 | 1.09e+00 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:003625714 | Esophagus | ESCC | multivesicular body organization | 30/8552 | 31/18723 | 1.04e-09 | 2.50e-08 | 30 |
GO:003625814 | Esophagus | ESCC | multivesicular body assembly | 29/8552 | 30/18723 | 2.21e-09 | 4.99e-08 | 29 |
GO:007198514 | Esophagus | ESCC | multivesicular body sorting pathway | 34/8552 | 37/18723 | 3.49e-09 | 7.39e-08 | 34 |
GO:003250915 | Esophagus | ESCC | endosome transport via multivesicular body sorting pathway | 29/8552 | 31/18723 | 1.92e-08 | 3.72e-07 | 29 |
GO:000703214 | Esophagus | ESCC | endosome organization | 61/8552 | 82/18723 | 1.13e-07 | 1.85e-06 | 61 |
GO:001906815 | Esophagus | ESCC | virion assembly | 31/8552 | 35/18723 | 1.40e-07 | 2.25e-06 | 31 |
GO:00453245 | Esophagus | ESCC | late endosome to vacuole transport | 23/8552 | 25/18723 | 1.39e-06 | 1.69e-05 | 23 |
GO:004675514 | Esophagus | ESCC | viral budding | 23/8552 | 26/18723 | 6.82e-06 | 6.90e-05 | 23 |
GO:00325113 | Esophagus | ESCC | late endosome to vacuole transport via multivesicular body sorting pathway | 16/8552 | 17/18723 | 3.46e-05 | 2.82e-04 | 16 |
GO:19048965 | Esophagus | ESCC | ESCRT complex disassembly | 10/8552 | 10/18723 | 3.94e-04 | 2.26e-03 | 10 |
GO:19049035 | Esophagus | ESCC | ESCRT III complex disassembly | 10/8552 | 10/18723 | 3.94e-04 | 2.26e-03 | 10 |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VTA1 | SNV | Missense_Mutation | c.278N>T | p.Tyr93Phe | p.Y93F | Q9NP79 | protein_coding | deleterious(0.04) | benign(0.398) | TCGA-KK-A6E5-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
VTA1 | SNV | Missense_Mutation | rs753854014 | c.524T>C | p.Ile175Thr | p.I175T | Q9NP79 | protein_coding | tolerated(0.5) | benign(0) | TCGA-HF-7134-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
VTA1 | SNV | Missense_Mutation | c.456C>G | p.Ile152Met | p.I152M | Q9NP79 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EL-A4KG-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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