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Gene: USP45 |
Gene summary for USP45 |
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Gene information | Species | Human | Gene symbol | USP45 | Gene ID | 85015 |
Gene name | ubiquitin specific peptidase 45 | |
Gene Alias | LCA19 | |
Cytomap | 6q16.2 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q70EL2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85015 | USP45 | NAFLD1 | Human | Liver | NAFLD | 1.14e-03 | 3.64e-01 | -0.04 |
85015 | USP45 | HCC1_Meng | Human | Liver | HCC | 2.12e-08 | -1.37e-02 | 0.0246 |
85015 | USP45 | HCC2_Meng | Human | Liver | HCC | 2.32e-04 | 1.46e-02 | 0.0107 |
85015 | USP45 | HCC1 | Human | Liver | HCC | 4.41e-02 | 1.75e+00 | 0.5336 |
85015 | USP45 | HCC2 | Human | Liver | HCC | 5.81e-04 | 1.22e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0070646 | Liver | NAFLD | protein modification by small protein removal | 29/1882 | 157/18723 | 9.11e-04 | 1.09e-02 | 29 |
GO:0016579 | Liver | NAFLD | protein deubiquitination | 26/1882 | 139/18723 | 1.35e-03 | 1.52e-02 | 26 |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP45 | SNV | Missense_Mutation | novel | c.86N>T | p.Ser29Leu | p.S29L | Q70EL2 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
USP45 | SNV | Missense_Mutation | rs755803890 | c.1054N>T | p.Arg352Trp | p.R352W | Q70EL2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
USP45 | SNV | Missense_Mutation | novel | c.1406C>A | p.Ser469Tyr | p.S469Y | Q70EL2 | protein_coding | tolerated(0.06) | possibly_damaging(0.837) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
USP45 | SNV | Missense_Mutation | novel | c.25N>A | p.Ala9Thr | p.A9T | Q70EL2 | protein_coding | tolerated_low_confidence(0.18) | benign(0.011) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
USP45 | SNV | Missense_Mutation | c.931A>C | p.Lys311Gln | p.K311Q | Q70EL2 | protein_coding | tolerated(0.48) | probably_damaging(0.914) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
USP45 | SNV | Missense_Mutation | c.580N>C | p.Asn194His | p.N194H | Q70EL2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
USP45 | SNV | Missense_Mutation | novel | c.1928N>T | p.Asn643Ile | p.N643I | Q70EL2 | protein_coding | tolerated(0.1) | probably_damaging(0.928) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP45 | SNV | Missense_Mutation | c.2072N>G | p.Gln691Arg | p.Q691R | Q70EL2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
USP45 | SNV | Missense_Mutation | c.2422N>A | p.Leu808Ile | p.L808I | Q70EL2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP45 | SNV | Missense_Mutation | c.582N>G | p.Asn194Lys | p.N194K | Q70EL2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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