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Gene: USP14 |
Gene summary for USP14 |
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Gene information | Species | Human | Gene symbol | USP14 | Gene ID | 9097 |
Gene name | ubiquitin specific peptidase 14 | |
Gene Alias | TGT | |
Cytomap | 18p11.32 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P54578 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9097 | USP14 | GSM4909287 | Human | Breast | IDC | 2.36e-07 | 4.04e-01 | 0.2057 |
9097 | USP14 | GSM4909291 | Human | Breast | IDC | 3.60e-05 | 4.08e-01 | 0.1753 |
9097 | USP14 | GSM4909293 | Human | Breast | IDC | 2.13e-22 | 5.00e-01 | 0.1581 |
9097 | USP14 | GSM4909296 | Human | Breast | IDC | 1.86e-02 | -1.04e-01 | 0.1524 |
9097 | USP14 | GSM4909311 | Human | Breast | IDC | 1.12e-06 | -1.85e-01 | 0.1534 |
9097 | USP14 | GSM4909312 | Human | Breast | IDC | 1.06e-02 | -1.62e-01 | 0.1552 |
9097 | USP14 | GSM4909319 | Human | Breast | IDC | 4.32e-10 | -1.33e-01 | 0.1563 |
9097 | USP14 | brca2 | Human | Breast | Precancer | 5.30e-05 | 1.68e-01 | -0.024 |
9097 | USP14 | P1 | Human | Breast | IDC | 1.71e-02 | 1.58e-02 | 0.1527 |
9097 | USP14 | DCIS2 | Human | Breast | DCIS | 4.49e-59 | 2.92e-01 | 0.0085 |
9097 | USP14 | LZE2T | Human | Esophagus | ESCC | 5.73e-14 | 2.38e+00 | 0.082 |
9097 | USP14 | LZE3D | Human | Esophagus | HGIN | 2.75e-02 | 4.34e-01 | 0.0668 |
9097 | USP14 | LZE4T | Human | Esophagus | ESCC | 2.91e-10 | 4.23e-01 | 0.0811 |
9097 | USP14 | LZE7T | Human | Esophagus | ESCC | 1.67e-05 | 6.25e-01 | 0.0667 |
9097 | USP14 | LZE8T | Human | Esophagus | ESCC | 5.28e-10 | 3.19e-02 | 0.067 |
9097 | USP14 | LZE20T | Human | Esophagus | ESCC | 7.72e-08 | 1.37e-01 | 0.0662 |
9097 | USP14 | LZE24T | Human | Esophagus | ESCC | 2.72e-14 | 4.40e-01 | 0.0596 |
9097 | USP14 | LZE21T | Human | Esophagus | ESCC | 8.77e-07 | 3.78e-01 | 0.0655 |
9097 | USP14 | LZE6T | Human | Esophagus | ESCC | 1.05e-10 | 5.51e-01 | 0.0845 |
9097 | USP14 | P1T-E | Human | Esophagus | ESCC | 3.46e-09 | 4.80e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00104989 | Breast | Precancer | proteasomal protein catabolic process | 58/1080 | 490/18723 | 1.54e-07 | 8.05e-06 | 58 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:19033629 | Breast | Precancer | regulation of cellular protein catabolic process | 36/1080 | 255/18723 | 6.03e-07 | 2.55e-05 | 36 |
GO:00421769 | Breast | Precancer | regulation of protein catabolic process | 47/1080 | 391/18723 | 1.50e-06 | 5.58e-05 | 47 |
GO:19030509 | Breast | Precancer | regulation of proteolysis involved in cellular protein catabolic process | 31/1080 | 221/18723 | 4.10e-06 | 1.27e-04 | 31 |
GO:00313309 | Breast | Precancer | negative regulation of cellular catabolic process | 34/1080 | 262/18723 | 8.16e-06 | 2.20e-04 | 34 |
GO:19058979 | Breast | Precancer | regulation of response to endoplasmic reticulum stress | 16/1080 | 82/18723 | 1.53e-05 | 3.75e-04 | 16 |
GO:19033638 | Breast | Precancer | negative regulation of cellular protein catabolic process | 14/1080 | 75/18723 | 8.54e-05 | 1.63e-03 | 14 |
GO:00098959 | Breast | Precancer | negative regulation of catabolic process | 36/1080 | 320/18723 | 9.92e-05 | 1.83e-03 | 36 |
GO:19035739 | Breast | Precancer | negative regulation of response to endoplasmic reticulum stress | 10/1080 | 44/18723 | 1.61e-04 | 2.69e-03 | 10 |
GO:00611369 | Breast | Precancer | regulation of proteasomal protein catabolic process | 24/1080 | 187/18723 | 1.99e-04 | 3.14e-03 | 24 |
GO:00431619 | Breast | Precancer | proteasome-mediated ubiquitin-dependent protein catabolic process | 42/1080 | 412/18723 | 2.49e-04 | 3.72e-03 | 42 |
GO:19030518 | Breast | Precancer | negative regulation of proteolysis involved in cellular protein catabolic process | 12/1080 | 64/18723 | 2.58e-04 | 3.83e-03 | 12 |
GO:20000599 | Breast | Precancer | negative regulation of ubiquitin-dependent protein catabolic process | 10/1080 | 48/18723 | 3.43e-04 | 4.81e-03 | 10 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP14 | SNV | Missense_Mutation | rs773654673 | c.1423N>A | p.Ala475Thr | p.A475T | P54578 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP14 | SNV | Missense_Mutation | rs749757792 | c.371N>A | p.Arg124His | p.R124H | P54578 | protein_coding | tolerated(0.06) | benign(0.288) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP14 | SNV | Missense_Mutation | novel | c.1214C>A | p.Ser405Tyr | p.S405Y | P54578 | protein_coding | tolerated(1) | benign(0.082) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
USP14 | SNV | Missense_Mutation | c.1112N>A | p.Arg371Gln | p.R371Q | P54578 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
USP14 | deletion | Frame_Shift_Del | novel | c.773delN | p.Thr258LysfsTer67 | p.T258Kfs*67 | P54578 | protein_coding | TCGA-BG-A3EW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
USP14 | SNV | Missense_Mutation | novel | c.401A>G | p.Lys134Arg | p.K134R | P54578 | protein_coding | tolerated(0.24) | benign(0.022) | TCGA-BC-A10S-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
USP14 | SNV | Missense_Mutation | c.613N>C | p.Ile205Leu | p.I205L | P54578 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-05-4426-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
USP14 | SNV | Missense_Mutation | c.574N>A | p.Gln192Lys | p.Q192K | P54578 | protein_coding | tolerated(0.26) | possibly_damaging(0.542) | TCGA-50-5933-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
USP14 | SNV | Missense_Mutation | c.915G>T | p.Leu305Phe | p.L305F | P54578 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
USP14 | SNV | Missense_Mutation | novel | c.1331N>T | p.Gln444Leu | p.Q444L | P54578 | protein_coding | tolerated(0.23) | benign(0.045) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | inhibitor | 252827537 | ||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | PMID26077642-Compound-Figure3A | |||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | inhibitor | 328083515 | ||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | Tricyclic heterocycle derivative 4 |
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