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Gene: UGT2B7 |
Gene summary for UGT2B7 |
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Gene information | Species | Human | Gene symbol | UGT2B7 | Gene ID | 7364 |
Gene name | UDP glucuronosyltransferase family 2 member B7 | |
Gene Alias | UDPGT 2B7 | |
Cytomap | 4q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006063 | UniProtAcc | P16662 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7364 | UGT2B7 | AEH-subject1 | Human | Endometrium | AEH | 7.33e-37 | 9.43e-01 | -0.3059 |
7364 | UGT2B7 | AEH-subject2 | Human | Endometrium | AEH | 4.38e-11 | 5.71e-01 | -0.2525 |
7364 | UGT2B7 | AEH-subject3 | Human | Endometrium | AEH | 1.56e-03 | 2.67e-01 | -0.2576 |
7364 | UGT2B7 | AEH-subject5 | Human | Endometrium | AEH | 4.10e-02 | 4.02e-01 | -0.2953 |
7364 | UGT2B7 | EEC-subject1 | Human | Endometrium | EEC | 5.99e-34 | 9.38e-01 | -0.2682 |
7364 | UGT2B7 | EEC-subject2 | Human | Endometrium | EEC | 1.42e-29 | 8.84e-01 | -0.2607 |
7364 | UGT2B7 | EEC-subject3 | Human | Endometrium | EEC | 1.87e-09 | 1.95e-01 | -0.2525 |
7364 | UGT2B7 | EEC-subject5 | Human | Endometrium | EEC | 1.46e-23 | 8.95e-01 | -0.249 |
7364 | UGT2B7 | GSM5276935 | Human | Endometrium | EEC | 1.04e-03 | -1.30e-01 | -0.123 |
7364 | UGT2B7 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.76e-07 | 9.96e-02 | -0.1869 |
7364 | UGT2B7 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.27e-07 | 2.80e-02 | -0.1875 |
7364 | UGT2B7 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.15e-09 | 1.82e-01 | -0.1883 |
7364 | UGT2B7 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.38e-06 | -7.80e-02 | -0.1934 |
7364 | UGT2B7 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.08e-23 | 4.35e-01 | -0.1917 |
7364 | UGT2B7 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 9.52e-15 | 3.57e-01 | -0.1916 |
7364 | UGT2B7 | NAFLD1 | Human | Liver | NAFLD | 2.89e-04 | 3.63e-01 | -0.04 |
7364 | UGT2B7 | HCC1_Meng | Human | Liver | HCC | 3.57e-68 | 1.24e-01 | 0.0246 |
7364 | UGT2B7 | HCC2 | Human | Liver | HCC | 6.48e-35 | 4.45e+00 | 0.5341 |
7364 | UGT2B7 | S027 | Human | Liver | HCC | 6.51e-20 | 1.43e+00 | 0.2446 |
7364 | UGT2B7 | S028 | Human | Liver | HCC | 1.35e-40 | 1.65e+00 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer | ||
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00082023 | Liver | NAFLD | steroid metabolic process | 69/1882 | 319/18723 | 5.90e-10 | 1.28e-07 | 69 |
GO:00424452 | Liver | NAFLD | hormone metabolic process | 36/1882 | 218/18723 | 1.98e-03 | 1.98e-02 | 36 |
GO:0008210 | Liver | NAFLD | estrogen metabolic process | 10/1882 | 38/18723 | 3.49e-03 | 3.00e-02 | 10 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:00082091 | Liver | HCC | androgen metabolic process | 21/7958 | 30/18723 | 2.15e-03 | 1.08e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa009832 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa009833 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UGT2B7 | SNV | Missense_Mutation | rs771987274 | c.1136G>A | p.Gly379Asp | p.G379D | P16662 | protein_coding | deleterious(0) | possibly_damaging(0.638) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2B7 | SNV | Missense_Mutation | novel | c.1340G>T | p.Arg447Ile | p.R447I | P16662 | protein_coding | deleterious(0.03) | benign(0.018) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2B7 | SNV | Missense_Mutation | c.1429N>T | p.Arg477Trp | p.R477W | P16662 | protein_coding | deleterious(0.02) | benign(0.112) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UGT2B7 | SNV | Missense_Mutation | novel | c.946N>G | p.Met316Val | p.M316V | P16662 | protein_coding | tolerated(0.08) | benign(0.055) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
UGT2B7 | SNV | Missense_Mutation | c.1112T>G | p.Phe371Cys | p.F371C | P16662 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UGT2B7 | SNV | Missense_Mutation | novel | c.817N>C | p.Asn273His | p.N273H | P16662 | protein_coding | tolerated(0.13) | benign(0.422) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
UGT2B7 | SNV | Missense_Mutation | novel | c.1421N>G | p.Lys474Arg | p.K474R | P16662 | protein_coding | deleterious(0.02) | benign(0.206) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
UGT2B7 | SNV | Missense_Mutation | c.948N>A | p.Met316Ile | p.M316I | P16662 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UGT2B7 | SNV | Missense_Mutation | novel | c.714N>T | p.Glu238Asp | p.E238D | P16662 | protein_coding | tolerated(0.12) | benign(0.045) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2B7 | SNV | Missense_Mutation | novel | c.911T>A | p.Val304Asp | p.V304D | P16662 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7364 | UGT2B7 | DRUGGABLE GENOME | methadone | METHADONE | 17178267,22676193 | |
7364 | UGT2B7 | DRUGGABLE GENOME | codeine | CODEINE | 25752520 | |
7364 | UGT2B7 | DRUGGABLE GENOME | lamotrigine | LAMOTRIGINE | 26213157,26790665,27096250,23263737 | |
7364 | UGT2B7 | DRUGGABLE GENOME | oxycodone | OXYCODONE | 29502154 | |
7364 | UGT2B7 | DRUGGABLE GENOME | buprenorphine | BUPRENORPHINE | 24256307 | |
7364 | UGT2B7 | DRUGGABLE GENOME | fluvastatin | FLUVASTATIN | ||
7364 | UGT2B7 | DRUGGABLE GENOME | simvastatin | SIMVASTATIN | ||
7364 | UGT2B7 | DRUGGABLE GENOME | morphine | MORPHINE | 17724700,25340733,24703092,16580900,12185559,28063968,31607718 | |
7364 | UGT2B7 | DRUGGABLE GENOME | aprepitant | APREPITANT | 26053558 | |
7364 | UGT2B7 | DRUGGABLE GENOME | fentanyl | FENTANYL | 32401749 |
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