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Gene: UGT2B17 |
Gene summary for UGT2B17 |
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Gene information | Species | Human | Gene symbol | UGT2B17 | Gene ID | 7367 |
Gene name | UDP glucuronosyltransferase family 2 member B17 | |
Gene Alias | BMND12 | |
Cytomap | 4q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006063 | UniProtAcc | O75795 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7367 | UGT2B17 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.39e-03 | -8.24e-01 | 0.0216 |
7367 | UGT2B17 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.17e-08 | 1.16e+00 | -0.0811 |
7367 | UGT2B17 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.95e-07 | 7.41e-01 | -0.1088 |
7367 | UGT2B17 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.68e-46 | 2.21e+00 | -0.1954 |
7367 | UGT2B17 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.55e-04 | -3.39e-01 | -0.2196 |
7367 | UGT2B17 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.00e-07 | 9.10e-01 | -0.1526 |
7367 | UGT2B17 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.82e-03 | 7.00e-01 | -0.1001 |
7367 | UGT2B17 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.90e-13 | 1.46e+00 | -0.059 |
7367 | UGT2B17 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.10e-04 | -5.82e-01 | -0.2061 |
7367 | UGT2B17 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.04e-14 | 1.45e+00 | -0.1462 |
7367 | UGT2B17 | HTA11_9341_2000001011 | Human | Colorectum | SER | 6.92e-04 | 8.63e-01 | -0.00410000000000005 |
7367 | UGT2B17 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.32e-20 | -7.58e-01 | 0.096 |
7367 | UGT2B17 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.04e-06 | -9.24e-01 | 0.0446 |
7367 | UGT2B17 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.38e-07 | -9.24e-01 | 0.0131 |
7367 | UGT2B17 | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.01e-21 | 1.86e+00 | 0.0171 |
7367 | UGT2B17 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.59e-32 | -8.14e-01 | 0.0674 |
7367 | UGT2B17 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.62e-02 | 8.29e-01 | -0.0124 |
7367 | UGT2B17 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.75e-49 | -9.24e-01 | 0.294 |
7367 | UGT2B17 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.81e-06 | -6.57e-01 | 0.281 |
7367 | UGT2B17 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.98e-49 | -9.24e-01 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04976 | Colorectum | FAP | Bile secretion | 24/1404 | 89/8465 | 8.76e-03 | 3.21e-02 | 1.96e-02 | 24 |
hsa049761 | Colorectum | FAP | Bile secretion | 24/1404 | 89/8465 | 8.76e-03 | 3.21e-02 | 1.96e-02 | 24 |
hsa05207 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
hsa052071 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UGT2B17 | SNV | Missense_Mutation | c.658N>G | p.Tyr220Asp | p.Y220D | O75795 | protein_coding | deleterious(0.01) | possibly_damaging(0.698) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UGT2B17 | SNV | Missense_Mutation | rs555824070 | c.202A>C | p.Lys68Gln | p.K68Q | O75795 | protein_coding | tolerated(0.1) | benign(0.271) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2B17 | SNV | Missense_Mutation | novel | c.1292N>C | p.Lys431Thr | p.K431T | O75795 | protein_coding | deleterious(0.05) | probably_damaging(0.93) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2B17 | SNV | Missense_Mutation | rs200806791 | c.460N>A | p.Val154Ile | p.V154I | O75795 | protein_coding | tolerated(0.63) | benign(0.007) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2B17 | SNV | Missense_Mutation | rs200116533 | c.405G>T | p.Lys135Asn | p.K135N | O75795 | protein_coding | deleterious(0.02) | possibly_damaging(0.558) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
UGT2B17 | SNV | Missense_Mutation | novel | c.704N>C | p.Gln235Pro | p.Q235P | O75795 | protein_coding | deleterious(0.05) | benign(0.079) | TCGA-H5-A2HR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UGT2B17 | insertion | In_Frame_Ins | novel | c.8_9insTCTCAACTGTGTAGCCAACAGAGAAGCGGAGACTGTACA | p.Leu3_Lys4insLeuAsnCysValAlaAsnArgGluAlaGluThrValGln | p.L3_K4insLNCVANREAETVQ | O75795 | protein_coding | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
UGT2B17 | insertion | Frame_Shift_Ins | novel | c.251dupA | p.Asn84LysfsTer2 | p.N84Kfs*2 | O75795 | protein_coding | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
UGT2B17 | insertion | Frame_Shift_Ins | novel | c.908_909insA | p.Asn303LysfsTer14 | p.N303Kfs*14 | O75795 | protein_coding | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
UGT2B17 | SNV | Missense_Mutation | novel | c.184N>T | p.Ile62Phe | p.I62F | O75795 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-DD-AACL-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7367 | UGT2B17 | ENZYME, DRUGGABLE GENOME | ibuprofen | IBUPROFEN | 25502615 |
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