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Gene: UGT2A3 |
Gene summary for UGT2A3 |
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Gene information | Species | Human | Gene symbol | UGT2A3 | Gene ID | 79799 |
Gene name | UDP glucuronosyltransferase family 2 member A3 | |
Gene Alias | UGT2A3 | |
Cytomap | 4q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006063 | UniProtAcc | Q6UWM9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79799 | UGT2A3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.04e-03 | -3.34e-01 | 0.0155 |
79799 | UGT2A3 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.29e-02 | 3.53e-01 | -0.1954 |
79799 | UGT2A3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.73e-03 | -3.42e-01 | -0.059 |
79799 | UGT2A3 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.19e-06 | -3.79e-01 | 0.096 |
79799 | UGT2A3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.15e-14 | -3.93e-01 | 0.0674 |
79799 | UGT2A3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.79e-04 | -4.05e-01 | 0.0588 |
79799 | UGT2A3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.23e-11 | -3.68e-01 | 0.294 |
79799 | UGT2A3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.05e-15 | -3.94e-01 | 0.3859 |
79799 | UGT2A3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.86e-04 | -2.88e-01 | 0.3005 |
79799 | UGT2A3 | A002-C-010 | Human | Colorectum | FAP | 3.52e-14 | -3.80e-01 | 0.242 |
79799 | UGT2A3 | A001-C-207 | Human | Colorectum | FAP | 3.03e-07 | -3.90e-01 | 0.1278 |
79799 | UGT2A3 | A015-C-203 | Human | Colorectum | FAP | 3.45e-11 | -2.83e-01 | -0.1294 |
79799 | UGT2A3 | A002-C-201 | Human | Colorectum | FAP | 3.19e-14 | -4.05e-01 | 0.0324 |
79799 | UGT2A3 | A002-C-203 | Human | Colorectum | FAP | 4.57e-16 | -3.93e-01 | 0.2786 |
79799 | UGT2A3 | A001-C-119 | Human | Colorectum | FAP | 6.53e-08 | -4.05e-01 | -0.1557 |
79799 | UGT2A3 | A001-C-108 | Human | Colorectum | FAP | 2.67e-20 | -4.05e-01 | -0.0272 |
79799 | UGT2A3 | A002-C-205 | Human | Colorectum | FAP | 8.31e-14 | -4.05e-01 | -0.1236 |
79799 | UGT2A3 | A001-C-104 | Human | Colorectum | FAP | 1.44e-14 | -3.64e-01 | 0.0184 |
79799 | UGT2A3 | A015-C-005 | Human | Colorectum | FAP | 1.52e-08 | -3.90e-01 | -0.0336 |
79799 | UGT2A3 | A015-C-006 | Human | Colorectum | FAP | 6.44e-09 | -4.05e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04976 | Colorectum | FAP | Bile secretion | 24/1404 | 89/8465 | 8.76e-03 | 3.21e-02 | 1.96e-02 | 24 |
hsa049761 | Colorectum | FAP | Bile secretion | 24/1404 | 89/8465 | 8.76e-03 | 3.21e-02 | 1.96e-02 | 24 |
hsa05207 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
hsa052071 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UGT2A3 | SNV | Missense_Mutation | rs561986343 | c.571N>C | p.Tyr191His | p.Y191H | Q6UWM9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UGT2A3 | SNV | Missense_Mutation | rs142020441 | c.1048N>T | p.Arg350Trp | p.R350W | Q6UWM9 | protein_coding | deleterious(0.01) | possibly_damaging(0.865) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UGT2A3 | SNV | Missense_Mutation | c.238N>T | p.Pro80Ser | p.P80S | Q6UWM9 | protein_coding | tolerated(0.98) | benign(0.057) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UGT2A3 | SNV | Missense_Mutation | novel | c.1334N>T | p.Arg445Ile | p.R445I | Q6UWM9 | protein_coding | deleterious(0.02) | benign(0.205) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2A3 | SNV | Missense_Mutation | rs375202534 | c.34C>T | p.Leu12Phe | p.L12F | Q6UWM9 | protein_coding | deleterious(0.05) | possibly_damaging(0.736) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2A3 | SNV | Missense_Mutation | novel | c.491N>C | p.Val164Ala | p.V164A | Q6UWM9 | protein_coding | deleterious(0.01) | possibly_damaging(0.604) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
UGT2A3 | SNV | Missense_Mutation | novel | c.630N>C | p.Lys210Asn | p.K210N | Q6UWM9 | protein_coding | deleterious(0.01) | possibly_damaging(0.825) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT2A3 | SNV | Missense_Mutation | novel | c.1030A>G | p.Thr344Ala | p.T344A | Q6UWM9 | protein_coding | tolerated(0.09) | possibly_damaging(0.863) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UGT2A3 | SNV | Missense_Mutation | c.449C>T | p.Pro150Leu | p.P150L | Q6UWM9 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UGT2A3 | SNV | Missense_Mutation | novel | c.1528T>G | p.Phe510Val | p.F510V | Q6UWM9 | protein_coding | deleterious(0.01) | benign(0.021) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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