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Gene: UGT1A10 |
Gene summary for UGT1A10 |
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Gene information | Species | Human | Gene symbol | UGT1A10 | Gene ID | 54575 |
Gene name | UDP glucuronosyltransferase family 1 member A10 | |
Gene Alias | GNT1 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006063 | UniProtAcc | Q5DT02 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54575 | UGT1A10 | LZE2T | Human | Esophagus | ESCC | 9.54e-06 | 5.62e-01 | 0.082 |
54575 | UGT1A10 | LZE4T | Human | Esophagus | ESCC | 2.35e-12 | 3.71e-01 | 0.0811 |
54575 | UGT1A10 | LZE8T | Human | Esophagus | ESCC | 3.19e-08 | 3.17e-01 | 0.067 |
54575 | UGT1A10 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.75e-01 | 0.0662 |
54575 | UGT1A10 | LZE21D1 | Human | Esophagus | HGIN | 5.38e-03 | 2.97e-01 | 0.0632 |
54575 | UGT1A10 | LZE24T | Human | Esophagus | ESCC | 2.32e-20 | 6.54e-01 | 0.0596 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:00424401 | Esophagus | ESCC | pigment metabolic process | 50/8552 | 84/18723 | 7.34e-03 | 2.64e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UGT1A10 | SNV | Missense_Mutation | c.272N>A | p.Met91Lys | p.M91K | Q9HAW8 | protein_coding | tolerated(1) | benign(0) | TCGA-44-2657-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UGT1A10 | SNV | Missense_Mutation | novel | c.640N>A | p.Leu214Met | p.L214M | Q9HAW8 | protein_coding | tolerated(0.09) | benign(0.142) | TCGA-44-2659-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | alimta | PD |
UGT1A10 | SNV | Missense_Mutation | c.662N>T | p.Gln221Leu | p.Q221L | Q9HAW8 | protein_coding | tolerated(0.53) | benign(0) | TCGA-55-6975-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
UGT1A10 | SNV | Missense_Mutation | c.475N>G | p.Lys159Glu | p.K159E | Q9HAW8 | protein_coding | tolerated(1) | probably_damaging(0.983) | TCGA-55-6981-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | chemo | CR | |
UGT1A10 | SNV | Missense_Mutation | novel | c.71N>G | p.Glu24Gly | p.E24G | Q9HAW8 | protein_coding | deleterious(0.03) | benign(0.091) | TCGA-78-7160-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unspecific | SD | |
UGT1A10 | SNV | Missense_Mutation | novel | c.832C>A | p.His278Asn | p.H278N | Q9HAW8 | protein_coding | tolerated(0.4) | benign(0.015) | TCGA-80-5608-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
UGT1A10 | SNV | Missense_Mutation | novel | c.335C>T | p.Ser112Leu | p.S112L | Q9HAW8 | protein_coding | tolerated(0.32) | benign(0.026) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
UGT1A10 | SNV | Missense_Mutation | c.119C>T | p.Thr40Ile | p.T40I | Q9HAW8 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-95-A4VP-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
UGT1A10 | SNV | Missense_Mutation | c.709A>G | p.Thr237Ala | p.T237A | Q9HAW8 | protein_coding | deleterious(0.02) | benign(0.144) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
UGT1A10 | SNV | Missense_Mutation | novel | c.11C>A | p.Ala4Glu | p.A4E | Q9HAW8 | protein_coding | tolerated_low_confidence(0.2) | benign(0.125) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | ANTINEOPLASTIC AGENT | 8689427 | ||
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | mycophenolic acid | 24220207 | ||
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | oxcarbazepine | OXCARBAZEPINE | 27900402 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | allopurinol | ALLOPURINOL | 27798726 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | febuxostat | FEBUXOSTAT | 27798726 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | ETOPOSIDE | ETOPOSIDE | 12695347 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | TROGLITAZONE | TROGLITAZONE | 12433820 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | PHENOBARBITAL | PHENOBARBITAL | 8263600 | |
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | MYCOPHENOLIC ACID | 15039300,10688250 | ||
54575 | UGT1A10 | DRUGGABLE GENOME, ENZYME | DICLOFENAC | DICLOFENAC | 8511777 |
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