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Gene: UBR2 |
Gene summary for UBR2 |
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Gene information | Species | Human | Gene symbol | UBR2 | Gene ID | 23304 |
Gene name | ubiquitin protein ligase E3 component n-recognin 2 | |
Gene Alias | C6orf133 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8IWV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23304 | UBR2 | CCI_1 | Human | Cervix | CC | 2.02e-05 | 7.67e-01 | 0.528 |
23304 | UBR2 | CCI_2 | Human | Cervix | CC | 9.76e-11 | 1.15e+00 | 0.5249 |
23304 | UBR2 | CCI_3 | Human | Cervix | CC | 4.97e-06 | 7.51e-01 | 0.516 |
23304 | UBR2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.15e-07 | -3.62e-01 | 0.0155 |
23304 | UBR2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.27e-13 | 7.02e-01 | -0.1954 |
23304 | UBR2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.59e-02 | 4.96e-01 | 0.281 |
23304 | UBR2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.95e-09 | -4.30e-01 | 0.3005 |
23304 | UBR2 | F007 | Human | Colorectum | FAP | 1.59e-03 | -2.80e-01 | 0.1176 |
23304 | UBR2 | A001-C-207 | Human | Colorectum | FAP | 2.60e-06 | -3.46e-01 | 0.1278 |
23304 | UBR2 | A015-C-203 | Human | Colorectum | FAP | 6.02e-31 | -4.23e-01 | -0.1294 |
23304 | UBR2 | A015-C-204 | Human | Colorectum | FAP | 9.42e-11 | -3.58e-01 | -0.0228 |
23304 | UBR2 | A014-C-040 | Human | Colorectum | FAP | 1.29e-05 | -4.67e-01 | -0.1184 |
23304 | UBR2 | A002-C-201 | Human | Colorectum | FAP | 1.37e-16 | -4.43e-01 | 0.0324 |
23304 | UBR2 | A002-C-203 | Human | Colorectum | FAP | 5.93e-07 | -2.83e-01 | 0.2786 |
23304 | UBR2 | A001-C-119 | Human | Colorectum | FAP | 2.38e-05 | -1.95e-01 | -0.1557 |
23304 | UBR2 | A001-C-108 | Human | Colorectum | FAP | 3.22e-15 | -2.09e-01 | -0.0272 |
23304 | UBR2 | A002-C-205 | Human | Colorectum | FAP | 2.81e-25 | -2.59e-01 | -0.1236 |
23304 | UBR2 | A001-C-104 | Human | Colorectum | FAP | 1.71e-03 | -2.33e-01 | 0.0184 |
23304 | UBR2 | A015-C-005 | Human | Colorectum | FAP | 3.64e-04 | -2.30e-01 | -0.0336 |
23304 | UBR2 | A015-C-006 | Human | Colorectum | FAP | 1.38e-19 | -5.90e-01 | -0.0994 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00011016 | Cervix | CC | response to acid chemical | 31/2311 | 135/18723 | 4.16e-04 | 4.22e-03 | 31 |
GO:00712292 | Cervix | CC | cellular response to acid chemical | 20/2311 | 80/18723 | 1.40e-03 | 1.10e-02 | 20 |
GO:00712301 | Cervix | CC | cellular response to amino acid stimulus | 18/2311 | 71/18723 | 2.01e-03 | 1.47e-02 | 18 |
GO:00432004 | Cervix | CC | response to amino acid | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0033522 | Colorectum | AD | histone H2A ubiquitination | 12/3918 | 26/18723 | 3.47e-03 | 2.51e-02 | 12 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00335221 | Colorectum | MSS | histone H2A ubiquitination | 12/3467 | 26/18723 | 1.16e-03 | 1.12e-02 | 12 |
GO:0031929 | Colorectum | MSS | TOR signaling | 35/3467 | 126/18723 | 6.91e-03 | 4.44e-02 | 35 |
GO:0016574 | Colorectum | MSS | histone ubiquitination | 16/3467 | 47/18723 | 8.22e-03 | 4.99e-02 | 16 |
GO:00431614 | Colorectum | FAP | proteasome-mediated ubiquitin-dependent protein catabolic process | 98/2622 | 412/18723 | 5.41e-08 | 4.20e-06 | 98 |
GO:00104984 | Colorectum | FAP | proteasomal protein catabolic process | 110/2622 | 490/18723 | 2.12e-07 | 1.26e-05 | 110 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBR2 | SNV | Missense_Mutation | rs770119982 | c.914N>T | p.Ser305Leu | p.S305L | Q8IWV8 | protein_coding | deleterious(0) | benign(0.266) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBR2 | SNV | Missense_Mutation | novel | c.4786N>A | p.Glu1596Lys | p.E1596K | Q8IWV8 | protein_coding | tolerated(1) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBR2 | SNV | Missense_Mutation | novel | c.2643N>A | p.Phe881Leu | p.F881L | Q8IWV8 | protein_coding | tolerated(0.39) | benign(0.006) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
UBR2 | SNV | Missense_Mutation | rs770725312 | c.410G>A | p.Arg137Gln | p.R137Q | Q8IWV8 | protein_coding | deleterious(0.01) | possibly_damaging(0.82) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBR2 | SNV | Missense_Mutation | novel | c.826N>T | p.Asp276Tyr | p.D276Y | Q8IWV8 | protein_coding | deleterious(0.03) | benign(0.315) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBR2 | SNV | Missense_Mutation | novel | c.1412N>G | p.Phe471Cys | p.F471C | Q8IWV8 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBR2 | SNV | Missense_Mutation | novel | c.5172N>G | p.Ile1724Met | p.I1724M | Q8IWV8 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBR2 | SNV | Missense_Mutation | c.2263N>C | p.Tyr755His | p.Y755H | Q8IWV8 | protein_coding | tolerated(0.61) | benign(0) | TCGA-DY-A1DC-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | capecitabine | PR | |
UBR2 | SNV | Missense_Mutation | c.4640N>C | p.Cys1547Ser | p.C1547S | Q8IWV8 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-F5-6813-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
UBR2 | SNV | Missense_Mutation | novel | c.4618A>G | p.Thr1540Ala | p.T1540A | Q8IWV8 | protein_coding | tolerated(0.72) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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