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Gene: TULP4 |
Gene summary for TULP4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TULP4 | Gene ID | 56995 |
Gene name | TUB like protein 4 | |
Gene Alias | TUSP | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9NRJ4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56995 | TULP4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.37e-25 | -7.41e-01 | 0.0155 |
56995 | TULP4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.35e-07 | -5.67e-01 | -0.1808 |
56995 | TULP4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.89e-04 | -8.00e-01 | 0.0216 |
56995 | TULP4 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.31e-08 | -5.84e-01 | -0.1088 |
56995 | TULP4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.16e-03 | -7.45e-01 | -0.2196 |
56995 | TULP4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.75e-08 | -6.92e-01 | -0.1207 |
56995 | TULP4 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.72e-04 | -5.20e-01 | -0.1526 |
56995 | TULP4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.96e-25 | -6.20e-01 | -0.1464 |
56995 | TULP4 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.29e-21 | -5.21e-01 | -0.1001 |
56995 | TULP4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.43e-06 | -4.55e-01 | -0.059 |
56995 | TULP4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.32e-02 | -6.69e-01 | -0.2061 |
56995 | TULP4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.73e-03 | -7.16e-01 | -0.1462 |
56995 | TULP4 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.44e-06 | -6.23e-01 | -0.0842 |
56995 | TULP4 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.58e-03 | -7.58e-01 | -0.00410000000000005 |
56995 | TULP4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.43e-03 | -4.81e-01 | -0.0179 |
56995 | TULP4 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.07e-17 | -7.43e-01 | 0.096 |
56995 | TULP4 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.36e-07 | -7.25e-01 | 0.0528 |
56995 | TULP4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.75e-10 | -6.97e-01 | 0.0338 |
56995 | TULP4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.12e-29 | -6.65e-01 | 0.0674 |
56995 | TULP4 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.51e-05 | -6.42e-01 | 0.0112 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TULP4 | SNV | Missense_Mutation | c.512N>A | p.Thr171Lys | p.T171K | Q9NRJ4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TULP4 | SNV | Missense_Mutation | c.2021N>A | p.Gly674Glu | p.G674E | Q9NRJ4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TULP4 | SNV | Missense_Mutation | c.2490N>C | p.Lys830Asn | p.K830N | Q9NRJ4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TULP4 | SNV | Missense_Mutation | rs117337831 | c.2848N>T | p.Arg950Cys | p.R950C | Q9NRJ4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TULP4 | SNV | Missense_Mutation | c.1799N>T | p.Thr600Met | p.T600M | Q9NRJ4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
TULP4 | SNV | Missense_Mutation | rs775324726 | c.1078G>A | p.Ala360Thr | p.A360T | Q9NRJ4 | protein_coding | deleterious(0.03) | possibly_damaging(0.56) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TULP4 | SNV | Missense_Mutation | rs776482908 | c.3352N>T | p.Arg1118Trp | p.R1118W | Q9NRJ4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.927) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TULP4 | SNV | Missense_Mutation | c.4306N>T | p.Pro1436Ser | p.P1436S | Q9NRJ4 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TULP4 | SNV | Missense_Mutation | c.756N>C | p.Gln252His | p.Q252H | Q9NRJ4 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TULP4 | SNV | Missense_Mutation | c.2786C>T | p.Ala929Val | p.A929V | Q9NRJ4 | protein_coding | deleterious_low_confidence(0) | benign(0.22) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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