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Gene: TTLL7 |
Gene summary for TTLL7 |
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Gene information | Species | Human | Gene symbol | TTLL7 | Gene ID | 79739 |
Gene name | tubulin tyrosine ligase like 7 | |
Gene Alias | TTLL7 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q6ZT98 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79739 | TTLL7 | LZE4T | Human | Esophagus | ESCC | 3.29e-05 | 1.75e-01 | 0.0811 |
79739 | TTLL7 | LZE7T | Human | Esophagus | ESCC | 5.95e-18 | 8.51e-01 | 0.0667 |
79739 | TTLL7 | P2T-E | Human | Esophagus | ESCC | 5.83e-09 | 1.73e-01 | 0.1177 |
79739 | TTLL7 | P8T-E | Human | Esophagus | ESCC | 1.50e-05 | 1.70e-01 | 0.0889 |
79739 | TTLL7 | P9T-E | Human | Esophagus | ESCC | 1.67e-03 | 9.06e-02 | 0.1131 |
79739 | TTLL7 | P10T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.51e-01 | 0.116 |
79739 | TTLL7 | P11T-E | Human | Esophagus | ESCC | 8.50e-07 | 3.98e-01 | 0.1426 |
79739 | TTLL7 | P12T-E | Human | Esophagus | ESCC | 4.96e-06 | 1.97e-01 | 0.1122 |
79739 | TTLL7 | P19T-E | Human | Esophagus | ESCC | 4.91e-07 | 5.28e-01 | 0.1662 |
79739 | TTLL7 | P26T-E | Human | Esophagus | ESCC | 6.65e-18 | 3.68e-01 | 0.1276 |
79739 | TTLL7 | P27T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.74e-01 | 0.1055 |
79739 | TTLL7 | P30T-E | Human | Esophagus | ESCC | 5.44e-10 | 4.21e-01 | 0.137 |
79739 | TTLL7 | P32T-E | Human | Esophagus | ESCC | 4.45e-19 | 4.09e-01 | 0.1666 |
79739 | TTLL7 | P37T-E | Human | Esophagus | ESCC | 1.74e-08 | 1.17e-01 | 0.1371 |
79739 | TTLL7 | P47T-E | Human | Esophagus | ESCC | 3.59e-02 | 9.16e-02 | 0.1067 |
79739 | TTLL7 | P48T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.61e-01 | 0.0959 |
79739 | TTLL7 | P49T-E | Human | Esophagus | ESCC | 3.41e-07 | 5.01e-01 | 0.1768 |
79739 | TTLL7 | P52T-E | Human | Esophagus | ESCC | 8.38e-06 | 1.70e-01 | 0.1555 |
79739 | TTLL7 | P57T-E | Human | Esophagus | ESCC | 5.71e-03 | 1.65e-01 | 0.0926 |
79739 | TTLL7 | P62T-E | Human | Esophagus | ESCC | 9.23e-03 | 1.29e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTLL7 | SNV | Missense_Mutation | novel | c.252N>T | p.Glu84Asp | p.E84D | Q6ZT98 | protein_coding | tolerated(0.21) | probably_damaging(0.931) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TTLL7 | SNV | Missense_Mutation | c.2544N>T | p.Arg848Ser | p.R848S | Q6ZT98 | protein_coding | deleterious_low_confidence(0.02) | benign(0.03) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TTLL7 | SNV | Missense_Mutation | c.270N>C | p.Gln90His | p.Q90H | Q6ZT98 | protein_coding | deleterious(0) | possibly_damaging(0.663) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TTLL7 | SNV | Missense_Mutation | rs774042881 | c.757N>A | p.Val253Met | p.V253M | Q6ZT98 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-DM-A0X9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTLL7 | SNV | Missense_Mutation | rs369684657 | c.2318N>A | p.Arg773His | p.R773H | Q6ZT98 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TTLL7 | SNV | Missense_Mutation | c.1367N>A | p.Arg456Gln | p.R456Q | Q6ZT98 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
TTLL7 | SNV | Missense_Mutation | c.139N>A | p.Gly47Arg | p.G47R | Q6ZT98 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-F5-6811-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTLL7 | deletion | In_Frame_Del | c.694_696delNNN | p.Lys232del | p.K232del | Q6ZT98 | protein_coding | TCGA-A6-5667-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
TTLL7 | deletion | Frame_Shift_Del | c.1564delN | p.Thr522LeufsTer19 | p.T522Lfs*19 | Q6ZT98 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
TTLL7 | SNV | Missense_Mutation | novel | c.2190N>G | p.Asp730Glu | p.D730E | Q6ZT98 | protein_coding | deleterious(0.04) | possibly_damaging(0.702) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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