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Gene: TTLL5 |
Gene summary for TTLL5 |
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Gene information | Species | Human | Gene symbol | TTLL5 | Gene ID | 23093 |
Gene name | tubulin tyrosine ligase like 5 | |
Gene Alias | CORD19 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q6EMB2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23093 | TTLL5 | CCI_1 | Human | Cervix | CC | 5.12e-09 | 9.34e-01 | 0.528 |
23093 | TTLL5 | CCI_2 | Human | Cervix | CC | 2.81e-06 | 7.17e-01 | 0.5249 |
23093 | TTLL5 | CCI_3 | Human | Cervix | CC | 1.98e-06 | 6.27e-01 | 0.516 |
23093 | TTLL5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.96e-02 | -3.04e-01 | -0.1808 |
23093 | TTLL5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.12e-03 | -2.59e-01 | 0.0674 |
23093 | TTLL5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.30e-05 | -3.62e-01 | 0.3859 |
23093 | TTLL5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.17e-09 | -4.27e-01 | 0.3005 |
23093 | TTLL5 | A015-C-203 | Human | Colorectum | FAP | 2.46e-23 | -4.17e-01 | -0.1294 |
23093 | TTLL5 | A015-C-204 | Human | Colorectum | FAP | 3.98e-07 | -4.59e-01 | -0.0228 |
23093 | TTLL5 | A002-C-201 | Human | Colorectum | FAP | 1.99e-10 | -3.07e-01 | 0.0324 |
23093 | TTLL5 | A001-C-119 | Human | Colorectum | FAP | 2.46e-03 | -3.36e-01 | -0.1557 |
23093 | TTLL5 | A001-C-108 | Human | Colorectum | FAP | 3.71e-09 | -2.83e-01 | -0.0272 |
23093 | TTLL5 | A002-C-205 | Human | Colorectum | FAP | 7.58e-16 | -3.51e-01 | -0.1236 |
23093 | TTLL5 | A015-C-005 | Human | Colorectum | FAP | 2.67e-03 | -2.57e-01 | -0.0336 |
23093 | TTLL5 | A015-C-006 | Human | Colorectum | FAP | 1.91e-12 | -3.29e-01 | -0.0994 |
23093 | TTLL5 | A015-C-106 | Human | Colorectum | FAP | 6.25e-09 | -3.04e-01 | -0.0511 |
23093 | TTLL5 | A002-C-114 | Human | Colorectum | FAP | 5.41e-16 | -4.53e-01 | -0.1561 |
23093 | TTLL5 | A015-C-104 | Human | Colorectum | FAP | 1.02e-23 | -4.49e-01 | -0.1899 |
23093 | TTLL5 | A001-C-014 | Human | Colorectum | FAP | 2.52e-06 | -2.62e-01 | 0.0135 |
23093 | TTLL5 | A002-C-016 | Human | Colorectum | FAP | 6.48e-16 | -3.13e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0150063 | Cervix | CC | visual system development | 63/2311 | 375/18723 | 6.58e-03 | 3.65e-02 | 63 |
GO:0001654 | Cervix | CC | eye development | 62/2311 | 371/18723 | 7.83e-03 | 4.13e-02 | 62 |
GO:0048880 | Cervix | CC | sensory system development | 63/2311 | 381/18723 | 9.29e-03 | 4.66e-02 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTLL5 | SNV | Missense_Mutation | c.2406N>T | p.Glu802Asp | p.E802D | Q6EMB2 | protein_coding | tolerated(0.09) | benign(0.025) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TTLL5 | SNV | Missense_Mutation | novel | c.37G>T | p.Ala13Ser | p.A13S | Q6EMB2 | protein_coding | tolerated(0.3) | benign(0.169) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TTLL5 | SNV | Missense_Mutation | rs151197710 | c.332G>A | p.Arg111His | p.R111H | Q6EMB2 | protein_coding | deleterious(0.05) | possibly_damaging(0.777) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TTLL5 | SNV | Missense_Mutation | novel | c.1870G>T | p.Ala624Ser | p.A624S | Q6EMB2 | protein_coding | tolerated(0.64) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TTLL5 | SNV | Missense_Mutation | novel | c.2571G>T | p.Gln857His | p.Q857H | Q6EMB2 | protein_coding | tolerated(0.1) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TTLL5 | SNV | Missense_Mutation | novel | c.3746C>T | p.Ser1249Phe | p.S1249F | Q6EMB2 | protein_coding | deleterious_low_confidence(0.04) | benign(0.172) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TTLL5 | SNV | Missense_Mutation | rs534989089 | c.1027N>T | p.Arg343Cys | p.R343C | Q6EMB2 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTLL5 | SNV | Missense_Mutation | c.2633A>C | p.Lys878Thr | p.K878T | Q6EMB2 | protein_coding | tolerated(0.08) | possibly_damaging(0.704) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTLL5 | SNV | Missense_Mutation | rs534989089 | c.1027N>T | p.Arg343Cys | p.R343C | Q6EMB2 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
TTLL5 | SNV | Missense_Mutation | novel | c.954N>C | p.Glu318Asp | p.E318D | Q6EMB2 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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