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Gene: TTC38 |
Gene summary for TTC38 |
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Gene information | Species | Human | Gene symbol | TTC38 | Gene ID | 55020 |
Gene name | tetratricopeptide repeat domain 38 | |
Gene Alias | LL22NC03-5H6.5 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5R3I4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55020 | TTC38 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.72e-08 | 5.24e-01 | -0.1808 |
55020 | TTC38 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.92e-08 | 4.12e-01 | -0.1954 |
55020 | TTC38 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.76e-06 | 6.23e-01 | -0.1526 |
55020 | TTC38 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.23e-06 | 4.02e-01 | -0.1464 |
55020 | TTC38 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.85e-04 | 5.72e-01 | -0.059 |
55020 | TTC38 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.79e-04 | 3.95e-01 | 0.3859 |
55020 | TTC38 | A015-C-203 | Human | Colorectum | FAP | 7.07e-10 | -2.16e-01 | -0.1294 |
55020 | TTC38 | A002-C-201 | Human | Colorectum | FAP | 2.67e-04 | -1.26e-01 | 0.0324 |
55020 | TTC38 | A001-C-108 | Human | Colorectum | FAP | 3.11e-08 | -1.66e-01 | -0.0272 |
55020 | TTC38 | A002-C-205 | Human | Colorectum | FAP | 2.46e-09 | -2.60e-01 | -0.1236 |
55020 | TTC38 | A015-C-006 | Human | Colorectum | FAP | 1.31e-04 | -2.04e-01 | -0.0994 |
55020 | TTC38 | A015-C-106 | Human | Colorectum | FAP | 4.40e-02 | -1.24e-01 | -0.0511 |
55020 | TTC38 | A002-C-114 | Human | Colorectum | FAP | 3.17e-06 | -1.70e-01 | -0.1561 |
55020 | TTC38 | A015-C-104 | Human | Colorectum | FAP | 1.06e-09 | -2.16e-01 | -0.1899 |
55020 | TTC38 | A001-C-014 | Human | Colorectum | FAP | 1.00e-06 | -2.64e-01 | 0.0135 |
55020 | TTC38 | A002-C-016 | Human | Colorectum | FAP | 4.11e-08 | -2.27e-01 | 0.0521 |
55020 | TTC38 | A015-C-002 | Human | Colorectum | FAP | 2.46e-05 | -2.67e-01 | -0.0763 |
55020 | TTC38 | A002-C-116 | Human | Colorectum | FAP | 1.16e-11 | -2.70e-01 | -0.0452 |
55020 | TTC38 | A014-C-008 | Human | Colorectum | FAP | 1.20e-04 | -1.59e-01 | -0.191 |
55020 | TTC38 | A018-E-020 | Human | Colorectum | FAP | 1.34e-06 | -8.84e-02 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC38 | SNV | Missense_Mutation | rs779627944 | c.661G>A | p.Ala221Thr | p.A221T | Q5R3I4 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC38 | SNV | Missense_Mutation | c.1249N>A | p.Val417Ile | p.V417I | Q5R3I4 | protein_coding | tolerated(0.28) | benign(0.037) | TCGA-EY-A1GF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTC38 | SNV | Missense_Mutation | rs779627944 | c.661N>A | p.Ala221Thr | p.A221T | Q5R3I4 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTC38 | SNV | Missense_Mutation | novel | c.884G>A | p.Ser295Asn | p.S295N | Q5R3I4 | protein_coding | tolerated(0.33) | benign(0.005) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTC38 | SNV | Missense_Mutation | rs751908725 | c.824N>G | p.Tyr275Cys | p.Y275C | Q5R3I4 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-K7-AAU7-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Chemotherapy | gemcitabine | PD |
TTC38 | SNV | Missense_Mutation | c.526N>G | p.Ile176Val | p.I176V | Q5R3I4 | protein_coding | tolerated(0.79) | benign(0.001) | TCGA-RC-A7SK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TTC38 | SNV | Missense_Mutation | novel | c.1174N>T | p.Asp392Tyr | p.D392Y | Q5R3I4 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-WJ-A86L-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC38 | SNV | Missense_Mutation | novel | c.640N>A | p.Ala214Thr | p.A214T | Q5R3I4 | protein_coding | deleterious(0.02) | possibly_damaging(0.837) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TTC38 | SNV | Missense_Mutation | novel | c.585C>G | p.Phe195Leu | p.F195L | Q5R3I4 | protein_coding | tolerated(0.63) | benign(0.003) | TCGA-43-A56U-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC38 | SNV | Missense_Mutation | novel | c.101N>T | p.Thr34Met | p.T34M | Q5R3I4 | protein_coding | tolerated(0.05) | possibly_damaging(0.566) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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