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Gene: TRIM66 |
Gene summary for TRIM66 |
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Gene information | Species | Human | Gene symbol | TRIM66 | Gene ID | 9866 |
Gene name | tripartite motif containing 66 | |
Gene Alias | C11orf29 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O15016 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9866 | TRIM66 | NAFLD1 | Human | Liver | NAFLD | 1.11e-06 | 7.03e-01 | -0.04 |
9866 | TRIM66 | HCC1_Meng | Human | Liver | HCC | 1.70e-17 | -6.98e-02 | 0.0246 |
9866 | TRIM66 | HCC2_Meng | Human | Liver | HCC | 7.87e-04 | -7.07e-02 | 0.0107 |
9866 | TRIM66 | HCC2 | Human | Liver | HCC | 1.43e-08 | 1.87e+00 | 0.5341 |
9866 | TRIM66 | HCC5 | Human | Liver | HCC | 1.11e-02 | 1.38e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM66 | SNV | Missense_Mutation | c.2885C>A | p.Ser962Tyr | p.S962Y | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TRIM66 | SNV | Missense_Mutation | novel | c.358N>G | p.Lys120Glu | p.K120E | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIM66 | SNV | Missense_Mutation | novel | c.3487N>T | p.Arg1163Cys | p.R1163C | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRIM66 | SNV | Missense_Mutation | c.3397N>C | p.Thr1133Pro | p.T1133P | protein_coding | deleterious(0.01) | possibly_damaging(0.88) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TRIM66 | SNV | Missense_Mutation | novel | c.1333N>G | p.Ser445Gly | p.S445G | protein_coding | tolerated(0.08) | benign(0.033) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRIM66 | SNV | Missense_Mutation | novel | c.3728N>A | p.Ser1243Tyr | p.S1243Y | protein_coding | deleterious(0.03) | possibly_damaging(0.642) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRIM66 | SNV | Missense_Mutation | novel | c.1073N>A | p.Ser358Tyr | p.S358Y | protein_coding | tolerated(0.67) | benign(0.348) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
TRIM66 | SNV | Missense_Mutation | novel | c.268N>A | p.Val90Met | p.V90M | protein_coding | tolerated(0.47) | benign(0) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIM66 | SNV | Missense_Mutation | c.3734T>C | p.Val1245Ala | p.V1245A | protein_coding | deleterious(0) | possibly_damaging(0.6) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
TRIM66 | SNV | Missense_Mutation | c.1352N>A | p.Pro451Gln | p.P451Q | protein_coding | tolerated(0.23) | benign(0.232) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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