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Gene: TRIM5 |
Gene summary for TRIM5 |
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Gene information | Species | Human | Gene symbol | TRIM5 | Gene ID | 85363 |
Gene name | tripartite motif containing 5 | |
Gene Alias | RNF88 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9C035 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85363 | TRIM5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.00e-02 | 1.41e-01 | 0.0155 |
85363 | TRIM5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.07e-05 | 3.08e-01 | -0.0811 |
85363 | TRIM5 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.82e-03 | 2.79e-01 | -0.1088 |
85363 | TRIM5 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.64e-09 | 3.08e-01 | -0.1954 |
85363 | TRIM5 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.44e-03 | 1.88e-01 | -0.1464 |
85363 | TRIM5 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.72e-06 | 2.15e-01 | -0.1001 |
85363 | TRIM5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.45e-07 | 3.33e-01 | -0.059 |
85363 | TRIM5 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.07e-09 | 4.35e-01 | -0.0842 |
85363 | TRIM5 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.47e-03 | 1.90e-01 | 0.096 |
85363 | TRIM5 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.67e-04 | 4.66e-01 | 0.0131 |
85363 | TRIM5 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.22e-05 | 2.52e-01 | 0.0338 |
85363 | TRIM5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.13e-05 | 1.98e-01 | 0.0674 |
85363 | TRIM5 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.40e-02 | 3.44e-01 | 0.0112 |
85363 | TRIM5 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.07e-03 | 2.67e-01 | 0.0588 |
85363 | TRIM5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.59e-21 | 6.51e-01 | 0.294 |
85363 | TRIM5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.33e-03 | 2.97e-01 | 0.281 |
85363 | TRIM5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.05e-13 | 3.32e-01 | 0.3859 |
85363 | TRIM5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.85e-10 | 2.82e-01 | 0.3005 |
85363 | TRIM5 | LZE8T | Human | Esophagus | ESCC | 2.13e-02 | 1.03e-01 | 0.067 |
85363 | TRIM5 | LZE24T | Human | Esophagus | ESCC | 3.70e-08 | 2.95e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:00018197 | Cervix | CC | positive regulation of cytokine production | 95/2311 | 467/18723 | 4.88e-07 | 1.85e-05 | 95 |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00324791 | Cervix | CC | regulation of type I interferon production | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:00326061 | Cervix | CC | type I interferon production | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:00705343 | Cervix | CC | protein K63-linked ubiquitination | 14/2311 | 56/18723 | 6.93e-03 | 3.74e-02 | 14 |
GO:00324815 | Cervix | CC | positive regulation of type I interferon production | 14/2311 | 58/18723 | 9.57e-03 | 4.73e-02 | 14 |
GO:00516072 | Cervix | CC | defense response to virus | 46/2311 | 265/18723 | 1.04e-02 | 4.97e-02 | 46 |
GO:01405462 | Cervix | CC | defense response to symbiont | 46/2311 | 265/18723 | 1.04e-02 | 4.97e-02 | 46 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0051701 | Colorectum | AD | biological process involved in interaction with host | 73/3918 | 203/18723 | 5.08e-07 | 1.88e-05 | 73 |
GO:0052126 | Colorectum | AD | movement in host environment | 63/3918 | 175/18723 | 2.85e-06 | 8.11e-05 | 63 |
GO:0050792 | Colorectum | AD | regulation of viral process | 59/3918 | 164/18723 | 5.95e-06 | 1.52e-04 | 59 |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0046718 | Colorectum | AD | viral entry into host cell | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa051704 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa03250 | Colorectum | MSS | Viral life cycle - HIV-1 | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa051705 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa032501 | Colorectum | MSS | Viral life cycle - HIV-1 | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa032509 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0325014 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa032502 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
hsa051709 | Liver | HCC | Human immunodeficiency virus 1 infection | 125/4020 | 212/8465 | 4.51e-04 | 1.94e-03 | 1.08e-03 | 125 |
hsa0325011 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
hsa0517012 | Liver | HCC | Human immunodeficiency virus 1 infection | 125/4020 | 212/8465 | 4.51e-04 | 1.94e-03 | 1.08e-03 | 125 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM5 | SNV | Missense_Mutation | rs769576530 | c.371G>A | p.Arg124His | p.R124H | Q9C035 | protein_coding | tolerated(0.2) | benign(0.274) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM5 | insertion | Frame_Shift_Ins | novel | c.1420_1421insCCATATTTGGAAACTGCACCCTC | p.Phe474SerfsTer12 | p.F474Sfs*12 | Q9C035 | protein_coding | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TRIM5 | deletion | Frame_Shift_Del | novel | c.1123delG | p.Val375TyrfsTer28 | p.V375Yfs*28 | Q9C035 | protein_coding | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | ||
TRIM5 | SNV | Missense_Mutation | novel | c.1220G>T | p.Gly407Val | p.G407V | Q9C035 | protein_coding | tolerated(0.12) | benign(0.297) | TCGA-ZS-A9CD-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TRIM5 | SNV | Missense_Mutation | novel | c.793N>A | p.Pro265Thr | p.P265T | Q9C035 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM5 | SNV | Missense_Mutation | novel | c.1220G>T | p.Gly407Val | p.G407V | Q9C035 | protein_coding | tolerated(0.12) | benign(0.297) | TCGA-71-8520-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TRIM5 | SNV | Missense_Mutation | novel | c.709N>G | p.His237Asp | p.H237D | Q9C035 | protein_coding | tolerated(0.09) | benign(0.01) | TCGA-56-8629-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
TRIM5 | insertion | Frame_Shift_Ins | novel | c.1303_1304insAGAAGGGG | p.Pro435GlnfsTer11 | p.P435Qfs*11 | Q9C035 | protein_coding | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TRIM5 | SNV | Missense_Mutation | novel | c.403N>T | p.Ala135Ser | p.A135S | Q9C035 | protein_coding | deleterious(0.01) | possibly_damaging(0.802) | TCGA-CR-7399-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM5 | SNV | Missense_Mutation | novel | c.255N>C | p.Leu85Phe | p.L85F | Q9C035 | protein_coding | deleterious(0.03) | benign(0.127) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
85363 | TRIM5 | ENZYME, B30_2 SPRY DOMAIN, DRUGGABLE GENOME | carboplatin | CARBOPLATIN | ||
85363 | TRIM5 | ENZYME, B30_2 SPRY DOMAIN, DRUGGABLE GENOME | paclitaxel | PACLITAXEL |
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