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Gene: TRIL |
Gene summary for TRIL |
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Gene information | Species | Human | Gene symbol | TRIL | Gene ID | 9865 |
Gene name | TLR4 interactor with leucine rich repeats | |
Gene Alias | TRIL | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q7L0X0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9865 | TRIL | male-WTA | Human | Thyroid | PTC | 1.29e-07 | 1.25e-01 | 0.1037 |
9865 | TRIL | PTC01 | Human | Thyroid | PTC | 1.50e-04 | 7.22e-02 | 0.1899 |
9865 | TRIL | PTC06 | Human | Thyroid | PTC | 2.24e-03 | 1.14e-01 | 0.2057 |
9865 | TRIL | PTC07 | Human | Thyroid | PTC | 5.85e-03 | 7.91e-02 | 0.2044 |
9865 | TRIL | ATC12 | Human | Thyroid | ATC | 5.95e-07 | 1.73e-01 | 0.34 |
9865 | TRIL | ATC13 | Human | Thyroid | ATC | 1.96e-38 | 9.16e-01 | 0.34 |
9865 | TRIL | ATC4 | Human | Thyroid | ATC | 5.39e-04 | 1.81e-01 | 0.34 |
9865 | TRIL | ATC5 | Human | Thyroid | ATC | 3.59e-51 | 9.97e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00022215 | Thyroid | PTC | pattern recognition receptor signaling pathway | 77/5968 | 172/18723 | 2.56e-04 | 1.84e-03 | 77 |
GO:000222114 | Thyroid | ATC | pattern recognition receptor signaling pathway | 80/6293 | 172/18723 | 2.89e-04 | 1.84e-03 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIL | SNV | Missense_Mutation | novel | c.1490C>A | p.Ser497Tyr | p.S497Y | Q7L0X0 | protein_coding | deleterious(0.02) | benign(0.037) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TRIL | SNV | Missense_Mutation | novel | c.398T>A | p.Leu133Gln | p.L133Q | Q7L0X0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4TK-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TRIL | SNV | Missense_Mutation | novel | c.534G>T | p.Leu178Phe | p.L178F | Q7L0X0 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIL | SNV | Missense_Mutation | novel | c.58N>A | p.Pro20Thr | p.P20T | Q7L0X0 | protein_coding | tolerated(0.23) | possibly_damaging(0.521) | TCGA-66-2770-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRIL | SNV | Missense_Mutation | novel | c.1190N>T | p.Arg397Leu | p.R397L | Q7L0X0 | protein_coding | deleterious(0.04) | possibly_damaging(0.831) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRIL | SNV | Missense_Mutation | novel | c.760C>A | p.Arg254Ser | p.R254S | Q7L0X0 | protein_coding | tolerated(0.23) | benign(0.158) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIL | SNV | Missense_Mutation | novel | c.132N>T | p.Arg44Ser | p.R44S | Q7L0X0 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-77-8148-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TRIL | SNV | Missense_Mutation | novel | c.548N>G | p.Tyr183Cys | p.Y183C | Q7L0X0 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
TRIL | insertion | Frame_Shift_Ins | novel | c.1300dupA | p.Thr434AsnfsTer192 | p.T434Nfs*192 | Q7L0X0 | protein_coding | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRIL | SNV | Missense_Mutation | novel | c.739C>G | p.Arg247Gly | p.R247G | Q7L0X0 | protein_coding | tolerated(0.77) | benign(0.003) | TCGA-CQ-5326-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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