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Gene: TNS1 |
Gene summary for TNS1 |
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Gene information | Species | Human | Gene symbol | TNS1 | Gene ID | 7145 |
Gene name | tensin 1 | |
Gene Alias | MST091 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B7Z6H8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7145 | TNS1 | NAFLD1 | Human | Liver | NAFLD | 2.41e-08 | 8.91e-01 | -0.04 |
7145 | TNS1 | S43 | Human | Liver | Cirrhotic | 3.07e-17 | 2.12e-01 | -0.0187 |
7145 | TNS1 | HCC1_Meng | Human | Liver | HCC | 4.43e-13 | -2.65e-01 | 0.0246 |
7145 | TNS1 | HCC2_Meng | Human | Liver | HCC | 1.76e-06 | -2.50e-01 | 0.0107 |
7145 | TNS1 | cirrhotic3 | Human | Liver | Cirrhotic | 1.86e-02 | 7.84e-04 | 0.0215 |
7145 | TNS1 | HCC2 | Human | Liver | HCC | 6.71e-06 | 2.72e+00 | 0.5341 |
7145 | TNS1 | HCC5 | Human | Liver | HCC | 1.15e-05 | -2.14e-01 | 0.4932 |
7145 | TNS1 | Pt13.b | Human | Liver | HCC | 8.86e-06 | 5.27e-02 | 0.0251 |
7145 | TNS1 | 047563_1562-all-cells | Human | Prostate | BPH | 6.34e-07 | 1.47e-01 | 0.0791 |
7145 | TNS1 | 048752_1579-all-cells | Human | Prostate | BPH | 1.20e-02 | 2.03e-01 | 0.1008 |
7145 | TNS1 | 052095_1628-all-cells | Human | Prostate | BPH | 2.20e-10 | 4.58e-01 | 0.1032 |
7145 | TNS1 | 052097_1595-all-cells | Human | Prostate | BPH | 5.92e-09 | 4.10e-01 | 0.0972 |
7145 | TNS1 | 052099_1652-all-cells | Human | Prostate | BPH | 3.54e-04 | 2.65e-01 | 0.1038 |
7145 | TNS1 | Dong_P1 | Human | Prostate | Tumor | 1.59e-14 | 4.98e-02 | 0.035 |
7145 | TNS1 | Dong_P3 | Human | Prostate | Tumor | 1.24e-17 | 1.19e-01 | 0.0278 |
7145 | TNS1 | Dong_P4 | Human | Prostate | Tumor | 1.39e-06 | 1.27e-01 | 0.0292 |
7145 | TNS1 | P7 | Human | Prostate | Tumor | 3.80e-03 | 5.79e-01 | -0.1025 |
7145 | TNS1 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.38e-15 | 8.42e-01 | 0.1633 |
7145 | TNS1 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 2.21e-21 | 9.19e-01 | 0.1608 |
7145 | TNS1 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.15e-10 | 8.16e-01 | 0.1604 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNS1 | SNV | Missense_Mutation | rs576154784 | c.577G>A | p.Gly193Ser | p.G193S | Q9HBL0 | protein_coding | deleterious(0) | possibly_damaging(0.875) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TNS1 | SNV | Missense_Mutation | c.4724N>A | p.Pro1575His | p.P1575H | Q9HBL0 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AA-3685-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNS1 | SNV | Missense_Mutation | novel | c.38T>C | p.Leu13Pro | p.L13P | Q9HBL0 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNS1 | SNV | Missense_Mutation | c.1655N>T | p.Pro552Leu | p.P552L | Q9HBL0 | protein_coding | tolerated(0.06) | benign(0.052) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TNS1 | SNV | Missense_Mutation | c.3371N>A | p.Ser1124Asn | p.S1124N | Q9HBL0 | protein_coding | tolerated(0.22) | benign(0.054) | TCGA-AA-3846-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TNS1 | SNV | Missense_Mutation | c.1003N>T | p.Arg335Cys | p.R335C | Q9HBL0 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-AA-3850-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TNS1 | SNV | Missense_Mutation | c.3825C>A | p.His1275Gln | p.H1275Q | Q9HBL0 | protein_coding | tolerated(0.36) | benign(0.027) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNS1 | SNV | Missense_Mutation | rs754895922 | c.70N>T | p.Ala24Ser | p.A24S | Q9HBL0 | protein_coding | tolerated(0.92) | benign(0.048) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
TNS1 | SNV | Missense_Mutation | c.1755G>T | p.Gln585His | p.Q585H | Q9HBL0 | protein_coding | tolerated(0.07) | benign(0.011) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNS1 | SNV | Missense_Mutation | novel | c.3386G>T | p.Arg1129Ile | p.R1129I | Q9HBL0 | protein_coding | tolerated(0.39) | benign(0.014) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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