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Gene: TNFAIP6 |
Gene summary for TNFAIP6 |
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Gene information | Species | Human | Gene symbol | TNFAIP6 | Gene ID | 7130 |
Gene name | TNF alpha induced protein 6 | |
Gene Alias | TSG-6 | |
Cytomap | 2q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P98066 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7130 | TNFAIP6 | GSM4909281 | Human | Breast | IDC | 1.39e-03 | -2.76e-01 | 0.21 |
7130 | TNFAIP6 | GSM4909282 | Human | Breast | IDC | 6.80e-14 | 4.73e-01 | -0.0288 |
7130 | TNFAIP6 | GSM4909285 | Human | Breast | IDC | 2.88e-05 | -2.87e-01 | 0.21 |
7130 | TNFAIP6 | GSM4909286 | Human | Breast | IDC | 3.69e-10 | -3.26e-01 | 0.1081 |
7130 | TNFAIP6 | GSM4909287 | Human | Breast | IDC | 1.48e-07 | -3.04e-01 | 0.2057 |
7130 | TNFAIP6 | GSM4909290 | Human | Breast | IDC | 1.11e-08 | -3.26e-01 | 0.2096 |
7130 | TNFAIP6 | GSM4909291 | Human | Breast | IDC | 1.07e-03 | -3.06e-01 | 0.1753 |
7130 | TNFAIP6 | GSM4909293 | Human | Breast | IDC | 1.75e-09 | -3.24e-01 | 0.1581 |
7130 | TNFAIP6 | GSM4909294 | Human | Breast | IDC | 7.71e-11 | -3.26e-01 | 0.2022 |
7130 | TNFAIP6 | GSM4909295 | Human | Breast | IDC | 4.83e-05 | -3.26e-01 | 0.0898 |
7130 | TNFAIP6 | GSM4909296 | Human | Breast | IDC | 8.04e-10 | -3.15e-01 | 0.1524 |
7130 | TNFAIP6 | GSM4909297 | Human | Breast | IDC | 7.71e-11 | -3.20e-01 | 0.1517 |
7130 | TNFAIP6 | GSM4909298 | Human | Breast | IDC | 7.71e-11 | -3.26e-01 | 0.1551 |
7130 | TNFAIP6 | GSM4909299 | Human | Breast | IDC | 3.74e-05 | -3.12e-01 | 0.035 |
7130 | TNFAIP6 | GSM4909300 | Human | Breast | IDC | 2.71e-04 | -3.26e-01 | 0.0334 |
7130 | TNFAIP6 | GSM4909301 | Human | Breast | IDC | 1.69e-10 | -3.26e-01 | 0.1577 |
7130 | TNFAIP6 | GSM4909302 | Human | Breast | IDC | 3.88e-07 | -3.01e-01 | 0.1545 |
7130 | TNFAIP6 | GSM4909303 | Human | Breast | IDC | 2.16e-02 | -3.26e-01 | 0.0438 |
7130 | TNFAIP6 | GSM4909304 | Human | Breast | IDC | 1.69e-10 | -3.26e-01 | 0.1636 |
7130 | TNFAIP6 | GSM4909305 | Human | Breast | IDC | 2.42e-08 | -3.26e-01 | 0.0436 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0050727 | Breast | Precancer | regulation of inflammatory response | 44/1080 | 386/18723 | 1.26e-05 | 3.22e-04 | 44 |
GO:00507271 | Breast | IDC | regulation of inflammatory response | 48/1434 | 386/18723 | 5.99e-04 | 7.54e-03 | 48 |
GO:00507272 | Breast | DCIS | regulation of inflammatory response | 46/1390 | 386/18723 | 9.91e-04 | 1.10e-02 | 46 |
GO:00321021 | Breast | DCIS | negative regulation of response to external stimulus | 46/1390 | 420/18723 | 5.19e-03 | 3.81e-02 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFAIP6 | SNV | Missense_Mutation | novel | c.115N>G | p.His39Asp | p.H39D | P98066 | protein_coding | deleterious(0) | possibly_damaging(0.552) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFAIP6 | SNV | Missense_Mutation | novel | c.389N>A | p.Pro130Gln | p.P130Q | P98066 | protein_coding | tolerated(0.14) | possibly_damaging(0.662) | TCGA-21-1076-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TNFAIP6 | SNV | Missense_Mutation | rs780367746 | c.515N>A | p.Arg172His | p.R172H | P98066 | protein_coding | tolerated(0.13) | probably_damaging(0.914) | TCGA-34-2605-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
TNFAIP6 | SNV | Missense_Mutation | novel | c.547N>C | p.Glu183Gln | p.E183Q | P98066 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-77-6842-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TNFAIP6 | SNV | Missense_Mutation | novel | c.758N>T | p.Ser253Phe | p.S253F | P98066 | protein_coding | deleterious(0.04) | benign(0.014) | TCGA-BA-4074-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
TNFAIP6 | SNV | Missense_Mutation | novel | c.468N>T | p.Glu156Asp | p.E156D | P98066 | protein_coding | tolerated(0.4) | benign(0) | TCGA-CQ-6225-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TNFAIP6 | SNV | Missense_Mutation | novel | c.581A>C | p.Glu194Ala | p.E194A | P98066 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-CV-5430-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
TNFAIP6 | SNV | Missense_Mutation | novel | c.815N>T | p.Gly272Val | p.G272V | P98066 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-QK-A8ZA-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
TNFAIP6 | SNV | Missense_Mutation | rs373227124 | c.346C>T | p.Arg116Cys | p.R116C | P98066 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-T2-A6WZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cetuximab | PD |
TNFAIP6 | SNV | Missense_Mutation | c.734T>C | p.Val245Ala | p.V245A | P98066 | protein_coding | tolerated(1) | benign(0.013) | TCGA-HC-7211-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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