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Gene: TMEM63A |
Gene summary for TMEM63A |
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Gene information | Species | Human | Gene symbol | TMEM63A | Gene ID | 9725 |
Gene name | transmembrane protein 63A | |
Gene Alias | HLD19 | |
Cytomap | 1q42.12 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R3T3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9725 | TMEM63A | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.65e-02 | -1.88e-01 | 0.0155 |
9725 | TMEM63A | HTA11_866_3004761011 | Human | Colorectum | AD | 4.21e-02 | 3.68e-01 | 0.096 |
9725 | TMEM63A | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.08e-03 | 4.21e-01 | 0.0338 |
9725 | TMEM63A | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.94e-08 | 5.62e-01 | 0.0674 |
9725 | TMEM63A | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.47e-02 | 9.66e-01 | 0.3487 |
9725 | TMEM63A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.88e-08 | 7.20e-01 | 0.281 |
9725 | TMEM63A | F007 | Human | Colorectum | FAP | 2.86e-02 | -1.91e-01 | 0.1176 |
9725 | TMEM63A | A015-C-203 | Human | Colorectum | FAP | 3.37e-21 | -1.92e-01 | -0.1294 |
9725 | TMEM63A | A015-C-204 | Human | Colorectum | FAP | 1.68e-04 | -1.37e-01 | -0.0228 |
9725 | TMEM63A | A014-C-040 | Human | Colorectum | FAP | 3.28e-03 | 1.54e-01 | -0.1184 |
9725 | TMEM63A | A002-C-201 | Human | Colorectum | FAP | 2.14e-12 | -2.47e-01 | 0.0324 |
9725 | TMEM63A | A002-C-203 | Human | Colorectum | FAP | 4.81e-02 | 4.17e-03 | 0.2786 |
9725 | TMEM63A | A001-C-119 | Human | Colorectum | FAP | 1.51e-08 | 2.42e-01 | -0.1557 |
9725 | TMEM63A | A001-C-108 | Human | Colorectum | FAP | 3.12e-14 | 6.62e-02 | -0.0272 |
9725 | TMEM63A | A002-C-021 | Human | Colorectum | FAP | 2.92e-02 | 2.53e-01 | 0.1171 |
9725 | TMEM63A | A002-C-205 | Human | Colorectum | FAP | 1.79e-19 | -5.96e-02 | -0.1236 |
9725 | TMEM63A | A001-C-104 | Human | Colorectum | FAP | 5.46e-03 | 2.02e-01 | 0.0184 |
9725 | TMEM63A | A015-C-005 | Human | Colorectum | FAP | 3.17e-02 | 1.28e-01 | -0.0336 |
9725 | TMEM63A | A015-C-006 | Human | Colorectum | FAP | 1.66e-14 | -1.95e-02 | -0.0994 |
9725 | TMEM63A | A015-C-106 | Human | Colorectum | FAP | 8.64e-09 | 6.51e-02 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM63A | SNV | Missense_Mutation | novel | c.2362C>A | p.Pro788Thr | p.P788T | O94886 | protein_coding | tolerated(0.53) | benign(0.025) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | rs116456190 | c.887G>A | p.Arg296Gln | p.R296Q | O94886 | protein_coding | tolerated(0.09) | benign(0.029) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | rs760049167 | c.634C>T | p.Arg212Trp | p.R212W | O94886 | protein_coding | deleterious(0.05) | benign(0.178) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | rs750546958 | c.524C>T | p.Pro175Leu | p.P175L | O94886 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | c.682N>T | p.Arg228Trp | p.R228W | O94886 | protein_coding | deleterious(0) | possibly_damaging(0.762) | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
TMEM63A | SNV | Missense_Mutation | novel | c.1778A>G | p.Asp593Gly | p.D593G | O94886 | protein_coding | deleterious(0.04) | possibly_damaging(0.752) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | rs200900214 | c.1781N>A | p.Arg594His | p.R594H | O94886 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | novel | c.1792A>G | p.Lys598Glu | p.K598E | O94886 | protein_coding | deleterious(0.04) | probably_damaging(0.941) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
TMEM63A | SNV | Missense_Mutation | rs761660004 | c.2243C>T | p.Pro748Leu | p.P748L | O94886 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | novel | c.1355C>T | p.Thr452Ile | p.T452I | O94886 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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