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Gene: TMEM248 |
Gene summary for TMEM248 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM248 | Gene ID | 55069 |
Gene name | transmembrane protein 248 | |
Gene Alias | C7orf42 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024RDK7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55069 | TMEM248 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.82e-07 | 5.39e-01 | -0.1808 |
55069 | TMEM248 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.16e-12 | 6.99e-01 | -0.0811 |
55069 | TMEM248 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.56e-12 | 5.80e-01 | -0.1088 |
55069 | TMEM248 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.14e-27 | 7.42e-01 | -0.1954 |
55069 | TMEM248 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.07e-05 | 8.32e-01 | -0.2602 |
55069 | TMEM248 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.17e-02 | 5.80e-01 | -0.2196 |
55069 | TMEM248 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.16e-03 | 3.79e-01 | -0.1207 |
55069 | TMEM248 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.83e-06 | 5.06e-01 | -0.1526 |
55069 | TMEM248 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.08e-13 | 6.06e-01 | -0.1464 |
55069 | TMEM248 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.91e-15 | 7.31e-01 | -0.059 |
55069 | TMEM248 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.82e-04 | 4.82e-01 | -0.0179 |
55069 | TMEM248 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.27e-14 | 5.66e-01 | 0.096 |
55069 | TMEM248 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.46e-05 | 6.99e-01 | 0.0446 |
55069 | TMEM248 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.69e-05 | 6.11e-01 | 0.0528 |
55069 | TMEM248 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.16e-06 | 3.97e-01 | 0.0674 |
55069 | TMEM248 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.28e-02 | 5.88e-01 | -0.0124 |
55069 | TMEM248 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.45e-05 | 4.74e-01 | 0.0588 |
55069 | TMEM248 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.49e-22 | 8.30e-01 | 0.294 |
55069 | TMEM248 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.72e-02 | 6.99e-01 | 0.3487 |
55069 | TMEM248 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.61e-21 | 9.56e-01 | 0.281 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM248 | SNV | Missense_Mutation | c.274G>T | p.Gly92Trp | p.G92W | Q9NWD8 | protein_coding | deleterious(0.03) | possibly_damaging(0.878) | TCGA-E8-A2EA-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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