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Gene: TMEM177 |
Gene summary for TMEM177 |
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Gene information | Species | Human | Gene symbol | TMEM177 | Gene ID | 80775 |
Gene name | transmembrane protein 177 | |
Gene Alias | TMEM177 | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q53S58 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80775 | TMEM177 | LZE4T | Human | Esophagus | ESCC | 1.70e-03 | 1.18e-01 | 0.0811 |
80775 | TMEM177 | LZE7T | Human | Esophagus | ESCC | 6.33e-03 | 1.82e-01 | 0.0667 |
80775 | TMEM177 | LZE8T | Human | Esophagus | ESCC | 1.10e-02 | 1.19e-01 | 0.067 |
80775 | TMEM177 | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 2.09e-01 | 0.068 |
80775 | TMEM177 | LZE24T | Human | Esophagus | ESCC | 3.74e-07 | 1.71e-01 | 0.0596 |
80775 | TMEM177 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.17e-01 | 0.0655 |
80775 | TMEM177 | LZE6T | Human | Esophagus | ESCC | 2.96e-03 | 1.90e-01 | 0.0845 |
80775 | TMEM177 | P1T-E | Human | Esophagus | ESCC | 2.97e-02 | 1.32e-01 | 0.0875 |
80775 | TMEM177 | P2T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.68e-01 | 0.1177 |
80775 | TMEM177 | P4T-E | Human | Esophagus | ESCC | 3.85e-16 | 3.79e-01 | 0.1323 |
80775 | TMEM177 | P5T-E | Human | Esophagus | ESCC | 5.00e-17 | 3.20e-01 | 0.1327 |
80775 | TMEM177 | P8T-E | Human | Esophagus | ESCC | 1.56e-10 | 6.95e-02 | 0.0889 |
80775 | TMEM177 | P9T-E | Human | Esophagus | ESCC | 4.01e-04 | 1.08e-01 | 0.1131 |
80775 | TMEM177 | P10T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.81e-01 | 0.116 |
80775 | TMEM177 | P11T-E | Human | Esophagus | ESCC | 2.10e-10 | 4.01e-01 | 0.1426 |
80775 | TMEM177 | P12T-E | Human | Esophagus | ESCC | 1.75e-25 | 4.59e-01 | 0.1122 |
80775 | TMEM177 | P15T-E | Human | Esophagus | ESCC | 1.22e-08 | 2.01e-01 | 0.1149 |
80775 | TMEM177 | P16T-E | Human | Esophagus | ESCC | 1.13e-16 | 2.67e-01 | 0.1153 |
80775 | TMEM177 | P17T-E | Human | Esophagus | ESCC | 2.60e-06 | 2.25e-01 | 0.1278 |
80775 | TMEM177 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 2.36e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM177 | SNV | Missense_Mutation | rs746730147 | c.697C>G | p.Arg233Gly | p.R233G | Q53S58 | protein_coding | deleterious(0) | possibly_damaging(0.759) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM177 | SNV | Missense_Mutation | novel | c.271N>T | p.Val91Leu | p.V91L | Q53S58 | protein_coding | tolerated(0.05) | benign(0.062) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM177 | SNV | Missense_Mutation | c.392G>T | p.Trp131Leu | p.W131L | Q53S58 | protein_coding | deleterious(0) | possibly_damaging(0.49) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TMEM177 | SNV | Missense_Mutation | novel | c.908N>C | p.Arg303Thr | p.R303T | Q53S58 | protein_coding | deleterious(0) | benign(0.349) | TCGA-CV-7089-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM177 | SNV | Missense_Mutation | novel | c.716N>G | p.Ser239Cys | p.S239C | Q53S58 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-CV-7414-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM177 | SNV | Missense_Mutation | novel | c.575N>T | p.Gly192Val | p.G192V | Q53S58 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TMEM177 | SNV | Missense_Mutation | c.475N>A | p.Val159Met | p.V159M | Q53S58 | protein_coding | tolerated(0.19) | benign(0.036) | TCGA-HC-8213-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD | |
TMEM177 | SNV | Missense_Mutation | novel | c.676N>T | p.Ala226Ser | p.A226S | Q53S58 | protein_coding | tolerated(0.42) | benign(0.005) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM177 | SNV | Missense_Mutation | rs368452165 | c.121G>A | p.Val41Met | p.V41M | Q53S58 | protein_coding | tolerated(0.08) | benign(0.407) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TMEM177 | SNV | Missense_Mutation | novel | c.152N>G | p.Gln51Arg | p.Q51R | Q53S58 | protein_coding | tolerated(0.39) | benign(0) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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