![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM156 |
Gene summary for TMEM156 |
![]() |
Gene information | Species | Human | Gene symbol | TMEM156 | Gene ID | 80008 |
Gene name | transmembrane protein 156 | |
Gene Alias | TMEM156 | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N614 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80008 | TMEM156 | HCC1_Meng | Human | Liver | HCC | 2.21e-05 | -2.98e-02 | 0.0246 |
80008 | TMEM156 | cirrhotic2 | Human | Liver | Cirrhotic | 1.02e-04 | 1.60e-01 | 0.0201 |
80008 | TMEM156 | HCC2 | Human | Liver | HCC | 5.57e-04 | 1.03e+00 | 0.5341 |
80008 | TMEM156 | HCC5 | Human | Liver | HCC | 1.05e-03 | 1.95e+00 | 0.4932 |
80008 | TMEM156 | S027 | Human | Liver | HCC | 2.68e-08 | 7.56e-01 | 0.2446 |
80008 | TMEM156 | S028 | Human | Liver | HCC | 2.81e-06 | 4.17e-01 | 0.2503 |
80008 | TMEM156 | S029 | Human | Liver | HCC | 2.58e-11 | 6.69e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM156 | SNV | Missense_Mutation | c.266N>G | p.Asp89Gly | p.D89G | Q8N614 | protein_coding | tolerated(0.62) | benign(0.001) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
TMEM156 | insertion | Nonsense_Mutation | novel | c.131_132insAGAATAAAT | p.Ser44_Asn45insGluTerIle | p.S44_N45insE*I | Q8N614 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMEM156 | insertion | Frame_Shift_Ins | novel | c.137_138insATACCTGA | p.Phe46LeufsTer11 | p.F46Lfs*11 | Q8N614 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
TMEM156 | SNV | Missense_Mutation | c.881N>A | p.Pro294Gln | p.P294Q | Q8N614 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TMEM156 | SNV | Missense_Mutation | c.112N>G | p.Leu38Val | p.L38V | Q8N614 | protein_coding | deleterious(0.04) | probably_damaging(0.949) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response | |
TMEM156 | SNV | Missense_Mutation | novel | c.497G>T | p.Gly166Val | p.G166V | Q8N614 | protein_coding | deleterious(0.03) | benign(0.165) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM156 | SNV | Missense_Mutation | novel | c.107C>T | p.Ser36Leu | p.S36L | Q8N614 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-43-A474-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
TMEM156 | SNV | Missense_Mutation | novel | c.327N>C | p.Met109Ile | p.M109I | Q8N614 | protein_coding | tolerated(0.23) | benign(0.001) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMEM156 | SNV | Missense_Mutation | c.332N>G | p.Phe111Cys | p.F111C | Q8N614 | protein_coding | deleterious(0.01) | probably_damaging(0.912) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
TMEM156 | insertion | In_Frame_Ins | novel | c.404_405insCAAGTGTAGTTTATCGAT | p.His135_Ser136insLysCysSerLeuSerIle | p.H135_S136insKCSLSI | Q8N614 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |