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Gene: TMC8 |
Gene summary for TMC8 |
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Gene information | Species | Human | Gene symbol | TMC8 | Gene ID | 147138 |
Gene name | transmembrane channel like 8 | |
Gene Alias | EV2 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | A0A024R8N8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147138 | TMC8 | LZE4T | Human | Esophagus | ESCC | 9.43e-11 | 4.16e-01 | 0.0811 |
147138 | TMC8 | LZE7T | Human | Esophagus | ESCC | 2.15e-10 | 5.19e-01 | 0.0667 |
147138 | TMC8 | LZE22T | Human | Esophagus | ESCC | 1.95e-03 | 3.46e-01 | 0.068 |
147138 | TMC8 | LZE21T | Human | Esophagus | ESCC | 5.21e-12 | 6.93e-01 | 0.0655 |
147138 | TMC8 | LZE6T | Human | Esophagus | ESCC | 3.14e-02 | 1.88e-01 | 0.0845 |
147138 | TMC8 | P1T-E | Human | Esophagus | ESCC | 9.29e-08 | 4.15e-01 | 0.0875 |
147138 | TMC8 | P2T-E | Human | Esophagus | ESCC | 1.45e-09 | 2.48e-01 | 0.1177 |
147138 | TMC8 | P4T-E | Human | Esophagus | ESCC | 2.91e-09 | 3.53e-01 | 0.1323 |
147138 | TMC8 | P5T-E | Human | Esophagus | ESCC | 2.69e-02 | 1.46e-01 | 0.1327 |
147138 | TMC8 | P11T-E | Human | Esophagus | ESCC | 1.34e-17 | 8.49e-01 | 0.1426 |
147138 | TMC8 | P12T-E | Human | Esophagus | ESCC | 9.43e-31 | 6.89e-01 | 0.1122 |
147138 | TMC8 | P20T-E | Human | Esophagus | ESCC | 2.58e-30 | 1.00e+00 | 0.1124 |
147138 | TMC8 | P21T-E | Human | Esophagus | ESCC | 1.99e-11 | 1.17e-01 | 0.1617 |
147138 | TMC8 | P22T-E | Human | Esophagus | ESCC | 3.77e-10 | 2.48e-01 | 0.1236 |
147138 | TMC8 | P23T-E | Human | Esophagus | ESCC | 1.03e-07 | 4.57e-01 | 0.108 |
147138 | TMC8 | P24T-E | Human | Esophagus | ESCC | 8.51e-11 | 3.30e-01 | 0.1287 |
147138 | TMC8 | P26T-E | Human | Esophagus | ESCC | 5.99e-55 | 1.19e+00 | 0.1276 |
147138 | TMC8 | P27T-E | Human | Esophagus | ESCC | 1.67e-33 | 7.44e-01 | 0.1055 |
147138 | TMC8 | P28T-E | Human | Esophagus | ESCC | 7.79e-30 | 5.57e-01 | 0.1149 |
147138 | TMC8 | P31T-E | Human | Esophagus | ESCC | 5.55e-03 | 1.09e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0097191111 | Esophagus | ESCC | extrinsic apoptotic signaling pathway | 159/8552 | 219/18723 | 4.12e-16 | 2.94e-14 | 159 |
GO:2001236111 | Esophagus | ESCC | regulation of extrinsic apoptotic signaling pathway | 111/8552 | 151/18723 | 2.97e-12 | 1.18e-10 | 111 |
GO:004339320 | Esophagus | ESCC | regulation of protein binding | 135/8552 | 196/18723 | 3.69e-11 | 1.22e-09 | 135 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:0051100111 | Esophagus | ESCC | negative regulation of binding | 109/8552 | 162/18723 | 2.10e-08 | 4.03e-07 | 109 |
GO:000862519 | Esophagus | ESCC | extrinsic apoptotic signaling pathway via death domain receptors | 59/8552 | 82/18723 | 1.23e-06 | 1.52e-05 | 59 |
GO:003209116 | Esophagus | ESCC | negative regulation of protein binding | 65/8552 | 94/18723 | 3.46e-06 | 3.82e-05 | 65 |
GO:005507617 | Esophagus | ESCC | transition metal ion homeostasis | 87/8552 | 138/18723 | 2.85e-05 | 2.37e-04 | 87 |
GO:0031333110 | Esophagus | ESCC | negative regulation of protein-containing complex assembly | 86/8552 | 141/18723 | 1.74e-04 | 1.14e-03 | 86 |
GO:190204117 | Esophagus | ESCC | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 35/8552 | 49/18723 | 2.32e-04 | 1.44e-03 | 35 |
GO:200123320 | Oral cavity | OSCC | regulation of apoptotic signaling pathway | 242/7305 | 356/18723 | 6.66e-29 | 3.24e-26 | 242 |
GO:004325420 | Oral cavity | OSCC | regulation of protein-containing complex assembly | 255/7305 | 428/18723 | 2.94e-18 | 3.15e-16 | 255 |
GO:009719120 | Oral cavity | OSCC | extrinsic apoptotic signaling pathway | 142/7305 | 219/18723 | 7.34e-15 | 4.55e-13 | 142 |
GO:005109820 | Oral cavity | OSCC | regulation of binding | 212/7305 | 363/18723 | 3.88e-14 | 2.15e-12 | 212 |
GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
GO:200123620 | Oral cavity | OSCC | regulation of extrinsic apoptotic signaling pathway | 100/7305 | 151/18723 | 1.07e-11 | 3.90e-10 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMC8 | SNV | Missense_Mutation | novel | c.1766N>C | p.Arg589Pro | p.R589P | Q8IU68 | protein_coding | tolerated(0.07) | benign(0.296) | TCGA-CV-7177-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMC8 | SNV | Missense_Mutation | c.340C>G | p.Arg114Gly | p.R114G | Q8IU68 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-G9-7521-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Hormone Therapy | luprolide | SD | |
TMC8 | SNV | Missense_Mutation | c.481N>T | p.Pro161Ser | p.P161S | Q8IU68 | protein_coding | tolerated(0.8) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMC8 | SNV | Missense_Mutation | c.133G>A | p.Asp45Asn | p.D45N | Q8IU68 | protein_coding | deleterious(0) | possibly_damaging(0.749) | TCGA-BR-7197-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMC8 | SNV | Missense_Mutation | c.2001N>T | p.Gln667His | p.Q667H | Q8IU68 | protein_coding | tolerated(0.1) | benign(0.135) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMC8 | SNV | Missense_Mutation | c.649T>C | p.Phe217Leu | p.F217L | Q8IU68 | protein_coding | tolerated(0.71) | possibly_damaging(0.874) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TMC8 | insertion | Frame_Shift_Ins | novel | c.1627_1628insT | p.Leu544SerfsTer267 | p.L544Sfs*267 | Q8IU68 | protein_coding | TCGA-BR-7703-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TMC8 | insertion | Frame_Shift_Ins | novel | c.1480dupC | p.Leu494ProfsTer7 | p.L494Pfs*7 | Q8IU68 | protein_coding | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | ||
TMC8 | insertion | Frame_Shift_Ins | novel | c.1475_1476insC | p.Leu494ProfsTer7 | p.L494Pfs*7 | Q8IU68 | protein_coding | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
TMC8 | deletion | Frame_Shift_Del | novel | c.1513delC | p.Leu505SerfsTer11 | p.L505Sfs*11 | Q8IU68 | protein_coding | TCGA-DJ-A3UM-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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