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Gene: TMC6 |
Gene summary for TMC6 |
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Gene information | Species | Human | Gene symbol | TMC6 | Gene ID | 11322 |
Gene name | transmembrane channel like 6 | |
Gene Alias | EV1 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R8V2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11322 | TMC6 | LZE4T | Human | Esophagus | ESCC | 2.93e-11 | 1.90e-01 | 0.0811 |
11322 | TMC6 | LZE5T | Human | Esophagus | ESCC | 1.04e-05 | 3.20e-01 | 0.0514 |
11322 | TMC6 | LZE7T | Human | Esophagus | ESCC | 3.55e-13 | 4.78e-01 | 0.0667 |
11322 | TMC6 | LZE8T | Human | Esophagus | ESCC | 5.57e-10 | 3.14e-01 | 0.067 |
11322 | TMC6 | LZE20T | Human | Esophagus | ESCC | 4.22e-04 | 2.08e-01 | 0.0662 |
11322 | TMC6 | LZE21D1 | Human | Esophagus | HGIN | 6.35e-03 | 2.88e-01 | 0.0632 |
11322 | TMC6 | LZE22D1 | Human | Esophagus | HGIN | 1.92e-04 | 1.95e-01 | 0.0595 |
11322 | TMC6 | LZE24T | Human | Esophagus | ESCC | 3.80e-20 | 2.81e-01 | 0.0596 |
11322 | TMC6 | LZE21T | Human | Esophagus | ESCC | 7.35e-10 | 3.66e-01 | 0.0655 |
11322 | TMC6 | LZE6T | Human | Esophagus | ESCC | 2.44e-06 | 2.83e-01 | 0.0845 |
11322 | TMC6 | P1T-E | Human | Esophagus | ESCC | 2.73e-12 | 4.83e-01 | 0.0875 |
11322 | TMC6 | P2T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.64e-01 | 0.1177 |
11322 | TMC6 | P4T-E | Human | Esophagus | ESCC | 1.40e-16 | 2.24e-01 | 0.1323 |
11322 | TMC6 | P5T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.20e-01 | 0.1327 |
11322 | TMC6 | P8T-E | Human | Esophagus | ESCC | 5.17e-27 | 4.65e-01 | 0.0889 |
11322 | TMC6 | P9T-E | Human | Esophagus | ESCC | 2.87e-20 | 2.23e-01 | 0.1131 |
11322 | TMC6 | P10T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.49e-01 | 0.116 |
11322 | TMC6 | P11T-E | Human | Esophagus | ESCC | 1.23e-16 | 8.87e-01 | 0.1426 |
11322 | TMC6 | P12T-E | Human | Esophagus | ESCC | 1.02e-31 | 5.05e-01 | 0.1122 |
11322 | TMC6 | P15T-E | Human | Esophagus | ESCC | 2.25e-29 | 5.40e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMC6 | SNV | Missense_Mutation | rs117065924 | c.310C>T | p.Arg104Cys | p.R104C | Q7Z403 | protein_coding | deleterious(0.04) | possibly_damaging(0.84) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | novel | c.39G>T | p.Glu13Asp | p.E13D | Q7Z403 | protein_coding | tolerated(0.06) | benign(0.184) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | novel | c.329N>T | p.Cys110Phe | p.C110F | Q7Z403 | protein_coding | deleterious(0.02) | benign(0) | TCGA-EO-A3AS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | novel | c.2292N>C | p.Lys764Asn | p.K764N | Q7Z403 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | novel | c.1946N>A | p.Ser649Asn | p.S649N | Q7Z403 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | c.667G>A | p.Ala223Thr | p.A223T | Q7Z403 | protein_coding | tolerated(0.4) | benign(0.023) | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMC6 | SNV | Missense_Mutation | rs778240150 | c.1220N>A | p.Arg407Gln | p.R407Q | Q7Z403 | protein_coding | tolerated(1) | benign(0) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | SNV | Missense_Mutation | novel | c.724N>A | p.Gly242Ser | p.G242S | Q7Z403 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
TMC6 | SNV | Missense_Mutation | rs750556964 | c.1333G>A | p.Ala445Thr | p.A445T | Q7Z403 | protein_coding | tolerated(0.7) | benign(0.003) | TCGA-KP-A3W1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMC6 | deletion | Frame_Shift_Del | novel | c.1698delT | p.Phe566LeufsTer14 | p.F566Lfs*14 | Q7Z403 | protein_coding | TCGA-D1-A17U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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